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Condition: Dementia

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Total 4555 results found since Jan 2013.

Diabetes and factors associated with cognitive and functional decline. The screening for CKD among older people across Europe (SCOPE) study
CONCLUSION: Decline in functional and cognitive status of community-dwelling older adults with DM was similar to participants without DM in a short period of 2 years of follow-up, though several clinical factors may increase its risk in this population.PMID:37668841 | DOI:10.1007/s40520-023-02536-2
Source: Aging Clinical and Experimental Research - September 5, 2023 Category: Geriatrics Authors: Francesc Formiga Ana Mar ía Badía-Tejero Andrea Corsonello Johan Ärnlöv Axel C Carlsson Francesco Mattace-Raso Lisanne Tap Tomasz Kostka Agnieszka Guligowska Cornel C Sieber Robert Kob Ronit Ben-Romano Ilan Yehoshua Regina Roller-Wirnsberger Gerhard H Source Type: research

Safeguarding Against Stroke Risk by Statins
Whereas mighty prospective randomized trials —and meta-analyses of these—rightly command the data used to drive guidelines and daily clinical practice, careful long-term follow-up of closely monitored cohorts can generate crucial discoveries not anticipated in a 5-year study. As just one example, findings from lifelong follow-up in the Ame rican Framingham studies and the Whitehall cohorts in the United Kingdom show a strong association between blood pressure in middle years and dementia in later life.
Source: Mayo Clinic Proceedings - September 1, 2023 Category: Internal Medicine Authors: Adrian J.B. Brady Tags: Editorial Source Type: research

Function and regulation of cis P ‐tau in the pathogenesis and treatment of conventional and nonconventional tauopathies
Cis –trans isomerization of protein plays an important role in protein folding, function, and degradation, which is regulated by peptidyl-proline isomerases (PPIases). The cis P-tau but not trans P-tau is resistant to protein dephosphorylation and degradation and also prone to protein aggregation and serves as an early driver of multiple neurodegenerative disease including Alzheimer disease (AD), traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), and vascular contributions to cognitive impairment and dementia (VCID). Cis P-tau antibody is the only clinical-stage therapeutic fo r AD that has shown the e...
Source: Journal of Neurochemistry - August 29, 2023 Category: Neuroscience Authors: Ruizhi Wang, Kun Ping Lu, Xiao Zhen Zhou Tags: REVIEW Source Type: research

Fast Heartburn Relief Without Deadly Drugs
Since gastroesophageal reflux disease (GERD) was first identified in the early 1930s, the number of people experiencing heartburn has increased substantially. In fact, one study shows that in just 10 years, the number of people experiencing:1 Any GERD symptoms increased by 30% Symptoms at least once a week increased by 47% Severe GERD increased by 24% While these numbers are concerning, I’ll admit they’re not surprising considering the typical American diet. Our nutrition-less, grain-based diet of carbohydrates and starches has wrecked our health and made our bodies behave in ways nature never intended. This has led ...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Heart Health Natural Cures Nutrition Source Type: news

Na ïve bayes classifier assisted automated detection of cerebral microbleeds in SWI brain images
Biochem Cell Biol. 2023 Aug 28. doi: 10.1139/bcb-2023-0156. Online ahead of print.ABSTRACTCerebral Microbleeds (CMBs) in the brain are the essential indicators of critical brain disorders such as dementia and ischemic stroke. Generally, CMBs are detected manually by experts which is an exhaustive task with limited productivity. Since, CMBs have complex morphological nature, so manual detection is prone to errors. This paper presents a machine learning-based automated Cerebral Microbleeds detection technique in the brain SWI scans based on statistical feature extraction and classification. The proposed method consists of th...
Source: Biochemistry and Cell Biology - August 28, 2023 Category: Biochemistry Authors: Tayyab Ateeq Zaid Bin Faheem Mohamed Ghoneimy Dr Jehad Ali PhD Computer Engineering Yang Li Abdullah Baz Source Type: research

Cortical superficial siderosis is associated with reactive astrogliosis in cerebral amyloid angiopathy
Cortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracerebral hemorrhage and is a risk factor for post-stroke dementia in cerebral amyloid angio...
Source: Journal of Neuroinflammation - August 27, 2023 Category: Neurology Authors: Corinne A. Auger, Valentina Perosa, Steven M. Greenberg, Susanne J. van Veluw and Mariel G. Kozberg Tags: Research Source Type: research

Can This Breakfast Food Reverse Alzheimer ’ s?
I’m sure you’ve noticed how expensive eggs have gotten lately. The price has soared more than any other food in the supermarket…up 60% from one year ago.1 One reason for skyrocketing prices is the ongoing avian flu epidemic. But another reason is that demand for “nature’s perfect food” has increased substantially. And that is good news because eggs are essential for your health – including the fight against Alzheimer’s. And that means they’re worth every penny for the way they protect your brain. Two breakthrough studies back up what I’ve been telling my patients for over three decades… That ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Brain Health Nutrition Source Type: news

This Overlooked Nutrient May Be The Key To Brain Power
Aging is inevitable. But have you noticed that some very elderly people still don’t miss a thing? Some of my patients fall into this category. I’ve worked with many centenarians who remain quick-witted, with keen memories and focus. You can be one of these people, too — an all-star senior… Inside all of you, your cells are constantly busy dividing up to two trillion times per day. The new cells replace old, damaged, or dead cells and help you live, grow and thrive. Human cell lines have built-in mortality. As your cells divide, there’s a limit at which their limit is reached. There’s an internal mechanism o...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Brain Health Source Type: news

Too Little Sleep Destroys DNA?
I talk to my patients about the danger of not sleeping all the time. Unfortunately, it’s a common problem that affects 75 million Americans. People who don’t sleep, or sleep poorly, have up to 400% more accidents that those who get a good night’s rest. Not getting enough sleep also increases your risk of developing chronic diseases. Studies, including a large meta-analysis of 470,000 adults, found that those who slept less than six hours developed a:1,2,3,4,5 48% increase in the incidence of coronary heart disease 30% increased risk of dementia 15% increase in the incidence of stroke 50% cancer risk 17% higher risk ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news

Patient Cognitive Status and Physician Recommendations for Cardiovascular Disease Treatment: Results of Two Nationwide, Randomized Survey Studies
ConclusionIn these randomized survey studies, physicians recommended fewer guideline-concordant AMI and stroke treatments to hypothetical patients with early-stage dementia than those with NC. We did not find evidence that physicians recommend fewer treatments to hypothetical patients with MCI than those with NC.
Source: Journal of General Internal Medicine - August 24, 2023 Category: Internal Medicine Source Type: research

Prevalence of dementia, heart disease and stroke in community-dwelling adults in Canada, 2016 –2021: opportunities for joint prevention
ConclusionRecent increases in the prevalence of dementia, heart disease and stroke in Canadian communities threaten to reverse any gains in vascular disease prevention over the past six years. Findings reveal the urgent need for intensified prevention efforts that are community-based with a focus on joint reduction in the shared risk factors contributing to all three diseases.
Source: Archives of Public Health - August 24, 2023 Category: International Medicine & Public Health Source Type: research

Anticholinergic Burden and Cognitive Impairment in Nursing Homes: A Comparison of Four Anticholinergic Scales
ConclusionsThe cumulative effect of medications with modest antimuscarinic activity may influence the cognitive performance of NH residents. The anticholinergic burden measured with the ACB scale should help identify NH residents who may benefit from reducing the anticholinergic burden.A clear direct relationship between anticholinergic burden and cognitive impairment was found only for the ACB Scale.
Source: Drugs and Aging - August 24, 2023 Category: Geriatrics Source Type: research