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Condition: Dementia
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Total 4555 results found since Jan 2013.
Exploring the occurrence and the risk factors of the desire for hastened death and depression in people with early-stage dementia in Greece
Palliat Support Care. 2023 Jul 10:1-9. doi: 10.1017/S1478951523001062. Online ahead of print.ABSTRACTOBJECTIVES: To assess the factors associated with desire for hastened death and depression in early-stage dementia as well as the association between them. Also, to explore the mediator and moderator role of age in the relationship between depression and desire for hasten death.METHODS: A prospective cross-sectional study including 100 patients diagnosed with early-stage dementia from a rehabilitation center between December 2018 and July 2019. Measurement tools used were the Mini-Mental State Examination, the Greek Montrea...
Source: Palliative and Supportive Care - July 10, 2023 Category: Palliative Care Authors: Sotiria Kostopoulou Athina Pinelopi Varveri Maria Nikoloudi Eleni Tsilika Efi Parpa Anna Zygogianni Kyriaki Mystakidou Source Type: research
Anatomy of the pontine arteries and perforators of the basilar artery in humans
J Anat. 2023 Jul 6. doi: 10.1111/joa.13927. Online ahead of print.ABSTRACTCerebral blood flow constitutes a critical area of interest for neurologists, neurosurgeons, and interventional radiologists as a social burden related to ischemic stroke, hemorrhagic stroke, and vascular dementia is expected to intensify. There is a great need to develop new and effective therapies, therefore deepening understanding of cerebrovascular anatomy, physiology, and pathology is crucial. The main aim of the study was to develop a comprehensive classification of the pontine arteries considering their typology, relations to the cranial nerve...
Source: Journal of Anatomy - July 7, 2023 Category: Anatomy Authors: Magdalena Kwiatkowska Rados ław Rzepliński Bogdan Ciszek Source Type: research
Assessment of cheese sign and its association with vascular risk factors: Data from PUMCH dementia cohort
CONCLUSIONS: The risk factors for cheese sign were hypertension, age, and stroke. Cheese sign consists of BGH, PVS, and lacunae/infarction.PMID:37415546 | DOI:10.1097/CM9.0000000000002785
Source: Chinese Medical Journal - July 7, 2023 Category: General Medicine Authors: Xinying Huang Bo Hou Jie Wang Jie Li Li Shang Chenhui Mao Liling Dong Caiyan Liu Feng Feng Jing Gao Bin Peng Source Type: research
Anatomy of the pontine arteries and perforators of the basilar artery in humans
J Anat. 2023 Jul 6. doi: 10.1111/joa.13927. Online ahead of print.ABSTRACTCerebral blood flow constitutes a critical area of interest for neurologists, neurosurgeons, and interventional radiologists as a social burden related to ischemic stroke, hemorrhagic stroke, and vascular dementia is expected to intensify. There is a great need to develop new and effective therapies, therefore deepening understanding of cerebrovascular anatomy, physiology, and pathology is crucial. The main aim of the study was to develop a comprehensive classification of the pontine arteries considering their typology, relations to the cranial nerve...
Source: Journal of Anatomy - July 7, 2023 Category: Anatomy Authors: Magdalena Kwiatkowska Rados ław Rzepliński Bogdan Ciszek Source Type: research
Assessment of cheese sign and its association with vascular risk factors: Data from PUMCH dementia cohort
CONCLUSIONS: The risk factors for cheese sign were hypertension, age, and stroke. Cheese sign consists of BGH, PVS, and lacunae/infarction.PMID:37415546 | DOI:10.1097/CM9.0000000000002785
Source: Chinese Medical Journal - July 7, 2023 Category: General Medicine Authors: Xinying Huang Bo Hou Jie Wang Jie Li Li Shang Chenhui Mao Liling Dong Caiyan Liu Feng Feng Jing Gao Bin Peng Source Type: research
Preface: Special issue “”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 7, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research
Mitochondrial encephalopathy with lactic-acidosis and stroke-like episodes syndrome presenting as progressive supranuclear palsy
Clinical manifestations of MELAS are broad and include stroke-like episodes, myopathy, cardiomyopathy, headaches, hearing impairment, dementia, epilepsy, lactic acidemia, cyclic vomiting, diabetes, and short stature. Most cases of MELAS present early in childhood, with only 1 –6% presenting after the age of 40 [1]. Progressive supranuclear palsy (PSP) is a neurodegenerative disorder which can be mimicked by a variety of conditions, such as CADASIL, cerebrovascular disease, and autoimmune encephalitis [2].
Source: Parkinsonism and Related Disorders - July 7, 2023 Category: Neurology Authors: Reece M. Hass, Jennifer L. Whitwell, Elizabeth Y. Coon, Keith A. Josephs, Farwa Ali Tags: Correspondence Source Type: research
Preface: Special issue “Brain Proteostasis in Health and Disease”
The special issue “Brain Proteostasis in Health and Disease” features both original and review articles written by specialists in the field of protein homeostasis. Deregulation of adequate proteostasis may contribute to brain diseases, including several neuropsychiatric and neurodegenerative conditions. Therefore , delineating the processes underlying protein synthesis, folding, stability, function, and degradation in brain cells is key to promoting brain function and identifying effective therapeutic options for neurological disorders. This special issue covers the roles of protein homeostasis in several me chanisms t...
Source: Journal of Neurochemistry - July 6, 2023 Category: Neuroscience Authors: Mychael V. Lourenco Tags: EDITORIAL Source Type: research
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy
Glutamate is the brain’s main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA...
Source: Frontiers in Neurology - July 6, 2023 Category: Neurology Source Type: research
Malnutrition risk in hospitalized patients measured with Nutrition Risk Screening 2002 tool and its association with in-hospital mortality
CONCLUSIONS: AMR revealed that NRS-2002 is positive in approximately half of the hospitalized patients, which is associated with in-hospital mortality independent of the underlying diseases. NT is related to weight gain and increased serum albumin.PMID:37401318 | DOI:10.26355/eurrev_202306_32820
Source: European Review for Medical and Pharmacological Sciences - July 4, 2023 Category: Drugs & Pharmacology Authors: O K Bakkaloglu M Bektas B Ince S Amikishiyev Y B Tor M Alt ınkaynak Y Goksoy B Ozmen S Buyukdemir S N Erten T S Akpinar B Saka Source Type: research
