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NOTCH3 C201R variant causes cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) that can be confused with early-onset Alzheimer's disease
NOTCH3 is the causative gene for autosomal dominant cerebral arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) which is associated with both stroke and dementia. When CADASIL presents primarily as dementia it can be difficult to distinguish from Alzheimer's disease (AD) at both the clinical and neuropathological levels.
Source: Journal of the Neurological Sciences - August 7, 2023 Category: Neurology Authors: Olena Korvatska, Stephanie A. Bucks, Rebecca A. Yoda, Amber Nolan, Michael O. Dorschner, Debby Tsuang, Suman Jayadev, Wendy H. Raskind, Thomas D. Bird Source Type: research
7 Ways to Bring a Dead Friendship Back to Life
It might sound obvious, in the midst of a loneliness crisis, that having friends matters. But many of us “underestimate the very real impact our friendships can have on our life,” says Marisa Franco, a psychologist and author of Platonic: How The Science of Attachment Can Help You Make—and Keep—Friends. “Connection is the most important factor predicting our health, both physical and mental.”
A growing body of research supports that point: Healthy, stable friendships can protect against depression and anxiety, increase life satisfaction, extend longevity, and improve health metrics li...
Source: TIME: Health - August 4, 2023 Category: Consumer Health News Authors: Angela Haupt Tags: Uncategorized healthscienceclimate Source Type: news
Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease
CONCLUSIONS: The simultaneous development of frailty and CI is associated with an increased risk of adverse cardiovascular outcomes including death compared with the development of each syndrome alone. Diagnostics to detect frailty and CI are critical in assessment of cardiovascular risk in the older population.PMID:37538136 | PMC:PMC10399211 | DOI:10.1016/j.jacadv.2023.100318
Source: Adv Data - August 4, 2023 Category: Epidemiology Authors: Abdulla A Damluji Naila Ijaz Shang-En Chung Qian-Li Xue Rani K Hasan Wayne B Batchelor Ariela R Orkaby Ajar Kochar Michael G Nanna David L Roth Jeremy D Walston Jon R Resar Gary Gerstenblith Source Type: research
Association of Plasma A β 42/40 Ratio and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study
DISCUSSION: A reduction in plasma Aβ42/Aβ40 is associated with an increased risk of subsequent epilepsy. Our observations provide a further validation of the link between Aβ, hyperexcitable states, and LOE.PMID:37541842 | DOI:10.1212/WNL.0000000000207635
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Emily L Johnson Kevin J Sullivan Andrea Lauren Christman Schneider Jeannette Simino Tom H Mosley Anna Kucharska-Newton David S Knopman Rebecca F Gottesman Source Type: research
Multicohort cross-sectional study of cognitive and behavioural digital biomarkers in neurodegeneration: the Living Lab Study protocol
Introduction and aims
Digital biomarkers can provide a cost-effective, objective and robust measure for neurological disease progression, changes in care needs and the effect of interventions. Motor function, physiology and behaviour can provide informative measures of neurological conditions and neurodegenerative decline. New digital technologies present an opportunity to provide remote, high-frequency monitoring of patients from within their homes. The purpose of the living lab study is to develop novel digital biomarkers of functional impairment in those living with neurodegenerative disease (NDD) and neurological condi...
Source: BMJ Open - August 3, 2023 Category: General Medicine Authors: Crook-Rumsey, M., Daniels, S. J. C., Abulikemu, S., Lai, H., Rapeaux, A., Hadjipanayi, C., Soreq, E., Li, L. M., Bashford, J., Jeyasingh-Jacob, J., Gruia, D. C., Lambert, D., Weil, R., Hampshire, A., Sharp, D. J., Haar, S. Tags: Open access, Neurology Source Type: research
The cysteine-altering p.R544C variant in the NOTCH3 gene is a probable candidate for blood pressure and relevant traits in the Taiwan Biobank
ConclusionNOTCH3 is a strong candidate for a role in stroke, dementia, and CADASIL, which has previously been linked to blood pressure changes. While our preliminary study suggests thatNOTCH3 p.R544C may influence blood pressure, stroke, and dementia in the Taiwan Biobank, replication in a well-powered external sample is required. This study also underlines considerable prospects of detecting novel genetic biomarkers in underrepresented worldwide populations.
Source: Journal of Neurology - August 1, 2023 Category: Neurology Source Type: research
Alteration in brain functional connectivity in patients with post-stroke cognitive impairment during memory task: A fNIRS study
Post-stroke cognitive impairment (PSCI) refers to a spectrum of cognitive deterioration following stroke, ranging from mild cognitive impairment to dementia. Cortical plastic alterations associated with post-stroke cognitive impairment are not well documented. It is universally acknowledged as a prevalent and severe clinical syndrome that has an adverse influence on the prognosis of stroke patients [1]. Although PSCI is an umbrella term for a variety of pathological conditions, memory, and cognition impairments are the most troubling for stroke survivors and their carers [2].
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Ying Kong, Wenna Peng, Jing Li, Chunjiao Zhu, Changjie Zhang, Yongmei Fan Source Type: research
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer & rsquo;s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules, Vol. 28, Pages 5624: Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Molecules doi: 10.3390/molecules28155624
Authors:
Ryszard Pluta
Barbara Miziak
Stanisław J. Czuczwar
Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation, oxidative stress, vasoconstriction, cerebral amyloid angiopathy,...
Source: Molecules - July 25, 2023 Category: Chemistry Authors: Ryszard Pluta Barbara Miziak Stanis ław J. Czuczwar Tags: Review Source Type: research
Roche enters partnership with Alnylam to co-develop and co-commercialise RNAi therapeutic zilebesiran to treat hypertension in patients with high cardiovascular risk
Partnership combines Roche ’s proven track record of successfully developing and launching innovative medicines worldwide withAlnylam ’s leadership in RNAi therapeuticsZilebesiran, a Phase 2 RNAi therapeutic, has best-in-disease potential for patients with hypertension at high risk of cardiovascular morbidity and mortality, by robustly and durably lowering blood pressureHypertension, the leading cause of cardiovascular disease, affects more than 1.2 billion adults worldwide. While several therapies exist, a significant unmet need, especially for high risk patients, remains.1Basel, 24 July 2023 - Roche (SIX: RO, ROG; OT...
Source: Roche Media News - July 24, 2023 Category: Pharmaceuticals Source Type: news
Relationship Between Direct Oral Anticoagulant Doses and Clinical Outcomes in Elderly Patients With Non-Valvular Atrial Fibrillation - ANAFIE Registry Sub-Analysis
CONCLUSIONS: Inappropriate low DOAC doses (under- or off-label dose) were not associated with stroke/SEE or major bleeding but were associated with all-cause death.PMID:37482411 | DOI:10.1253/circj.CJ-23-0143
Source: Circulation Journal - July 23, 2023 Category: Cardiology Authors: Masaharu Akao Hiroshi Inoue Takeshi Yamashita Hirotsugu Atarashi Takanori Ikeda Yukihiro Koretsune Ken Okumura Shinya Suzuki Hiroyuki Tsutsui Kazunori Toyoda Atsushi Hirayama Masahiro Yasaka Takenori Yamaguchi Satoshi Teramukai Tetsuya Kimura Yoshiyuki Mo Source Type: research
