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Condition: Dementia

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Total 4555 results found since Jan 2013.

Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Neurobiol Aging. 2023 May 5;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Online ahead of print.ABSTRACTStroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injections of miR-20a-3p, a small noncoding RNA (miRNA) delivered after stroke improves acute stroke outcomes in middle-aged male and female rats. The present study tested whether mir-20a-3p treatment would also ameliorate stroke-induced cognitive decline in the chronic phase. Acyclic...
Source: Neurobiology of Aging - June 19, 2023 Category: Geriatrics Authors: Dayalan Sampath Taylor E Branyan Kylee G Markowsky Rithvik Gunda Nadia Samiya Andre Obenaus Farida Sohrabji Source Type: research

New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD.
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research

Estimate of the prevalence of subjects with chronic diseases in a province of Northern Italy: a retrospective study based on administrative databases
Conclusions Despite the difficulty of having a unique definition of chronic disease, the prevalence obtained was coherent with the estimates reported by other national surveillance systems such as Passi and Passi d’Argento. Underestimates were observed when international comparisons were done; however, when we used less stringent definitions of chronic diseases, similar results were obtained.
Source: BMJ Open - June 19, 2023 Category: General Medicine Authors: Airoldi, C., Pagnoni, F., Cena, T., Ceriotti, D., De Ambrosi, D., De Vito, M., Faggiano, F. Tags: Open access, Public health Source Type: research

New insights on the potential effect of vinpocetine in Parkinson ’s disease: one of the neglected warden and baffling topics
In conclusion, this review indicated that VPN could be effective in the management of PD.
Source: Metabolic Brain Disease - June 19, 2023 Category: Neurology Source Type: research

Higher serum uric acid is associated with poorer cognitive performance in healthy middle-aged people: a cross-sectional study
AbstractAge-related cognitive impairment can occur many years before the onset of the clinical symptoms of dementia. Uric acid (UA), a metabolite of purine-rich foods, has been shown to be positively associated with improved cognitive function, but such association remains controversial. Moreover, most of the previous studies investigating the association included elderly participants with memory-related diseases. Therefore, the present study aimed at investigating whether serum UA (sUA) is associated with cognitive performance in healthy middle-aged individuals. We conducted a cross-sectional study on a cohort of middle-a...
Source: Internal and Emergency Medicine - June 17, 2023 Category: Emergency Medicine Source Type: research

Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies
Adv Nutr. 2023 Jun 14:S2161-8313(23)01328-5. doi: 10.1016/j.advnut.2023.06.007. Online ahead of print.ABSTRACTThis umbrella review aims to provide a systematic and comprehensive overview of current evidence from prospective studies on the diverse health effects of cheese consumption. We searched PubMed, Embase, and Cochrane Library to identify meta-analyses/pooled analyses of prospective studies examining the associations between cheese consumption and major health outcomes from inception to August 31, 2022. We reanalyzed and updated previous meta-analyses and performed de novo meta-analyses with recently published prospec...
Source: Adv Data - June 16, 2023 Category: Epidemiology Authors: Mingjie Zhang Xiaocong Dong Zihui Huang Xue Li Yue Zhao Yingyao Wang Huilian Zhu Aiping Fang Edward L Giovannucci Source Type: research

Serum folate and risk of disabling dementia: a community-based nested case-control study
CONCLUSION: In this nested case-control study with a long follow-up, low serum folate levels were associated with an increased risk of disabling dementia among Japanese individuals.PMID:37314940 | DOI:10.1080/1028415X.2023.2218533
Source: Cancer Control - June 14, 2023 Category: Cancer & Oncology Authors: Rie Kishida Kazumasa Yamagishi Ai Ikeda Mina Hayama-Terada Yuji Shimizu Isao Muraki Mitsumasa Umesawa Hironori Imano Tomoko Sankai Takeo Okada Akihiko Kitamura Masahiko Kiyama Hiroyasu Iso CIRCS Investigators Source Type: research

Cerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation
J Zhejiang Univ Sci B. 2023 Jun 15;24(6):530-538. doi: 10.1631/jzus.B2200444.ABSTRACTConsidering the surgical risk stratification for patients with severe calcific aortic stenosis (AS), transcatheter aortic valve replacement (TAVR) is a reliable alternative to surgical aortic valve replacement (SAVR) (Fan et al., 2020, 2021; Lee et al., 2021). Despite the favorable clinical benefits of TAVR, stroke remains a dreaded perioperative complication (Auffret et al., 2016; Kapadia et al., 2016; Kleiman et al., 2016; Huded et al., 2019). Ischemic overt stroke, identified in 1.4% to 4.3% of patients in TAVR clinical practice, has be...
Source: J Zhejiang Univ Sci ... - June 13, 2023 Category: Science Authors: Xianbao Liu Hanyi Dai Jiaqi Fan Dao Zhou Gangjie Zhu Abuduwufuer Yidilisi Jun Chen Yeming Xu Lihan Wang Jian'an Wang Source Type: research