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Cancer: Squamous Cell Carcinoma

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Total 86 results found since Jan 2013.

Tumor Embolism Through Right-to-Left Shunt Due to Venous Invasion of Esophageal Carcinoma
A 69-year-old man was admitted to the hospital with right hemiparesis and global aphasia. Perfusion computed tomography imaging revealed ischemic penumbra in the middle cerebral artery territory. Angiography showed left middle cerebral artery occlusion. Mechanical thrombectomy with one pass was performed, and successful recanalization was obtained. Embolic material was retrieved; it contained tumor fragments with atypical keratinizing squamous cell carcinoma. Contrast computed tomography imaging indicated tumor invasion into the superior vena cava, and contrast transcranial Doppler indicated the presence of a right-to-left...
Source: Journal of Stroke and Cerebrovascular Diseases - October 1, 2020 Category: Neurology Authors: Suguru Araki, Kota Maekawa, Kazuto Kobayashi, Takanori Sano, Tadashi Yabana, Masunari Shibata, Fumitaka Miya Tags: Case Report Source Type: research

The basaloid variant of squamous cell carcinoma in an uncommon location
Microscopic aspects of basaloid squamous cell carcinoma (BSCC) are well defined, and its prevalence is rare in the mouth. Current research points to similarity of its course in relation to conventional squamous cell carcinoma; however, there is lack of information about its clinical behavior and prognosis. An 83-year-old male patient complained of a “lump inside the mouth,” noticed 4 months ago. Medical history revealed heart failure, systemic arterial hypertension, Alzheimer’s disease, history of stroke, and smoking (2 packs a day) for 30 years, discontinued 20 years ago.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2020 Category: ENT & OMF Authors: GABRIELA MOURA CHICRALA, RAQUEL D ’AQUINO GARCIA CAMINHA, SILAS ANTONIO JUVENCIO DE FREITAS FILHO, DENISE TOSTES OLIVEIRA, PAULO SÉRGIO DA SILVA SANTOS Tags: 20190182 Source Type: research

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Management of Radiation Induced Carotid Stenosis in Head and Neck Cancer.
CONCLUSION: RT in patients with HNSCC holds a significant risk factor of developing carotid artery stenosis and cerebrovascular events. Carotid stenting is preferable mode of treatment for radiation-induced stenosis. A screening program with doppler ultrasonography enables pre-stroke detection of carotid stenosis. PMID: 31146165 [PubMed - as supplied by publisher]
Source: Translational Oncology - May 26, 2019 Category: Cancer & Oncology Authors: Trojanowski P, Sojka M, Trojanowska A, Wolski A, Roman T, Jargiello T Tags: Transl Oncol Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Long non-coding SNHG1 in cancer
ConclusionSNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment.
Source: Clinica Chimica Acta - March 6, 2019 Category: Laboratory Medicine Source Type: research

Long non-coding SNHG1 in cancer.
CONCLUSION: SNHG1 likely acts as a useful tumour biomarker for cancer diagnosis, prognosis and treatment. PMID: 30849309 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - March 4, 2019 Category: Chemistry Authors: Thin K, Tu JC, Sudheesh C Tags: Clin Chim Acta Source Type: research

Diagnosis and Treatment of Squamous Cell Carcinoma in Lower Lip: Case Report
A 67-year-old woman attended the stomatology clinic complaining of a wound on the lip, painful, with an evolution of 3 months. During this period, she was treated by a dermatologist for herpes simplex, but without resolution. Anamnesis indicated systemic arterial hypertension and previous stroke; she denied smoking or performing activities causing sun exposure. A physical examination revealed an exophytic ulcer on the lower lip with a crusted necrotic background, indurated rounded borders, soft base, 1.5  cm in size, and loss of the mucocutaneous line.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 1, 2018 Category: ENT & OMF Authors: Rayane Velloso De Almeida, Miriam Beatriz Jord ão Moreira Sarruf, Ana Flávia Schuler De Assumpção Leite, Adriana Terezinha Neves Novellino Alves, Simone De Queiroz Chaves Lourenço, Jacqueline Tavares Silva Fernandes, Josiane Costa Rodrigues De Sá Tags: Oral and Maxillofacial Pathology Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Creating a lung adenocarcinoma canvas, one brush stroke at a time
In their carefully characterized large cohort of resected adenocarcinomas reported in this issue of the Journal, Takamochi and colleagues1 demonstrate that epidermal growth factor receptor gene (EGFR) mutations are associated with better prognoses and that subtypes of mutations are not. With nearly 1000 patients analyzed, the study serves as an important guidepost as we navigate treatment courses, weighing the relative importance of each genetic change —particularly driver mutations in lung cancer, both adenocarcinomas and squamous cell carcinomas.
Source: The Journal of Thoracic and Cardiovascular Surgery - July 22, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Sai Yendamuri Tags: Editorial commentary Source Type: research

7 medtech stories we missed this week: June 2, 2017
[Photo from unsplash.com]From Implandata receiving CE Marking to Inolife eyeing up-listing, here are 7 medtech stories we missed this week but thought were still worth mentioning. 1. Dextera seeks expanded indications for MicroCutter 5/80 stapler Dextera Surgical announced in a June 1 press release that it has filed a 510(k) with the FDA for its MicroCutter 5/80 stapler. The company wants to expand the indications of the MicroCutter 5/80 for use in liver, pancreas, kidney and spleen surgeries. Currently, the staplers are used for transection and resection in multiple open minimally-invasive urologic, thoracic and pediatr...
Source: Mass Device - June 2, 2017 Category: Medical Devices Authors: Danielle Kirsh Tags: Business/Financial News Clinical Trials News Well Regulatory/Compliance Research & Development c2 Therapeutics Dextera Surgical DreaMed Diabetes EndoGastric Solutions Inc. Implandata Inolife MicroTransponder Inc. Source Type: news

Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity
We present an autopsy case of repetitive stroke due to tumor emboli, indistinguishable from thromboembolism with a hypercoagulable state in its clinical course. A 72-year-old man diagnosed with stage IVA oropharyngeal squamous cell carcinoma received chemoradiotherapy. Follow-up imaging revealed mediastinal lymph nodes and pulmonary metastasis. One year later, the patient experienced right arm weakness, and brain magnetic resonance imaging showed acute ischemic lesions in multiple vascular territories.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2017 Category: Neurology Authors: Junji Takasugi, Manabu Sakaguchi, Naoki Oyama, Yasufumi Gon, Yasukazu Terasaki, Tsutomu Sasaki, Susumu Nakahara, Kenji Ohshima, Yumiko Hori, Eiichi Morii, Hideki Mochizuki Tags: Case Studies Source Type: research

Bilateral lingual artery stenosis: A rare, late complication of chemoradiotherapy
Discussion Small vessel disease is a possible complication in patients treated by RT for head and neck cancer. Although the risk of these complications is not directly related to the total radiation dose, higher doses appear to accelerate the development of vascular lesions. Practitioners must be aware of the possibility of these complications, especially in patients surviving more than 5 years.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - March 10, 2017 Category: ENT & OMF Source Type: research