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Therapy: Immunotherapy

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Total 258 results found since Jan 2013.

Increased 18F-FDGuptake on PET in hepatocellular carcinoma is associated with level ofPDL1 expression that regulated by beta-catenin
Conclusion: The above results demonstrate that 18F-FDG PET/CT is closely related to the expression of PDL1 in HCC, and it is an important criterion that not only predicts the anti-cancer response of anti-PDL1 immunotherapy through that 18F-FDG PET/CT but also reflects the prognosis Research Support: This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2011-0030086) and and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2016R1E1A1A01943303) and h was supported by the Basic Science Rese...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Jeon, J., Lee, M., Kim, Y. S., Yun, M. Tags: Radiotherapy and Monitoring Therapy Source Type: research

PD-L1 overexpression is partially regulated by EGFR/HER2 signaling and associated with poor prognosis in patients with non-small-cell lung cancer
AbstractImmunocheckpoint inhibitors targeting the programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) axis have shown promising results in patients with non-small-cell lung cancer (NSCLC). Recent research has shown that epidermal growth factor receptor (EGFR) signaling affects PD-L1 expression in NSCLC cells; however, the mechanism regulating PD-L1 expression in tumor cells remains unclear. Using immunohistochemistry, we evaluated the impact of expression of PD-L1 and EGF family receptors EGFR and human epidermal growth factor receptor 2 (HER2) in tumor cells from 91 patients with pathological Stage IA –IIIA NSCLC. ...
Source: Cancer Immunology, Immunotherapy - March 25, 2017 Category: Cancer & Oncology Source Type: research

The emerging role of exosome and microvesicle ‐ (EMV‐) based cancer therapeutics and immunotherapy
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - March 1, 2017 Category: Cancer & Oncology Authors: Colin Moore, Uchini Kosgodage, Sigrun Lange, Jameel M. Inal Tags: Mini Review Source Type: research

Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Leili Aghebati-Maleki, Mahdi Shabani, Behzad Baradaran, Morteza Motallebnezhad, Jafar Majidi, Mehdi Yousefi Chronic lymphocytic leukemia (CLL) is characterized by reposition of malignant B cells in the blood, bone marrow, spleen and lymph nodes. It remains the most common leukemia in the Western world. Within the recent years, major breakthroughs have been made to prolong the survival and improve the health of patients. Despite these advances, CLL is still recognized as a disease without definitive cure. New treatment approache...
Source: Biomedicine and Pharmacotherapy - February 1, 2017 Category: Drugs & Pharmacology Source Type: research

COX-2 inhibitor prevents tumor induced down regulation of classical DC lineage specific transcription factor Zbtb46 resulting in immunocompetent DC and decreased tumor burden.
We report that the tumor derived prostanoids down regulated classical dendritic cells DC (cDC) lineage specific transcription factor Zbtb46 in the progenitor cells which affects its differentiation. Prostanoids also induced ERK/CREB/IL-10 signaling pathway in DC that is more important for maturation of DC. This was observed under in vitro as well as in vivo conditions leading to phenotypic and functional impairment of DC. siRNA mediated knockdown of Zbtb46 and not exogenous IL-10 mimicked the effects of tumor conditioned medium (TCM) on suppression of maturation markers. Treatment of tumor cells with COX-2 inhibitor NS-398...
Source: Immunology Letters - January 31, 2017 Category: Allergy & Immunology Authors: Pandey VK, Amin PJ, Shankar BS Tags: Immunol Lett Source Type: research

Receptor tyrosine kinase-like orphan receptor 1 (ROR-1): An emerging target for diagnosis and therapy of chronic lymphocytic leukemia.
Abstract Chronic lymphocytic leukemia (CLL) is characterized by reposition of malignant B cells in the blood, bone marrow, spleen and lymph nodes. It remains the most common leukemia in the Western world. Within the recent years, major breakthroughs have been made to prolong the survival and improve the health of patients. Despite these advances, CLL is still recognized as a disease without definitive cure. New treatment approaches, based on unique targets and novel drugs, are highly desired for CLL therapy. The Identification and subsequent targeting of molecules that are overexpressed uniquely in malignant cells...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 31, 2017 Category: Drugs & Pharmacology Authors: Aghebati-Maleki L, Shabani M, Baradaran B, Motallebnezhad M, Majidi J, Yousefi M Tags: Biomed Pharmacother Source Type: research

Abstract B57: RNAi Nanotechnology for Cancer Target Validation and Therapy
RNA interference (RNAi) represents a promising strategy for identification and validation of putative therapeutic targets, and for treatment of a myriad of important human diseases including cancer. The ubiquitous application of RNAi in cancer research and therapy is nevertheless hindered by the challenge of effective systemic in vivo delivery of RNAi agents (e.g., siRNA) to solid tumors, which requires overcoming of multiple physiological barriers, such as enzymatic degradation, rapid elimination by renal excretion or by the mononuclear phagocyte system (MPS), poor tumor penetration, and insufficient cellular uptake and e...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Jinjun Shi Tags: Tumor Immunology/Immunotherapy Source Type: research

Correlation between the high expression levels of cancer-germline genes with clinical characteristics in esophageal squamous cell carcinoma.
In this study, we aimed to evaluate the mRNA expression of cancer-germline genes, expression of the encoded proteins in patients with esophageal squamous cell carcinoma (ESCC) and their correlations with clinical characteristics. In addition, the effects of downregulation cancer-germline genes on ESCC cells were assessed in vitro. Our results showed that cancer-germline genes were frequently expressed in ESCC samples. The positive rates of in ESCC samples were: 87% of MAGE-A3, 60% of MAGE-A4, 65% of MAGE-C2, and 20% of NY-ESO-1 at mRNA level. MAGE-A3 expression was associated with age, lymph node metastasis and tumor stage...
Source: Histology and Histopathology - November 23, 2016 Category: Cytology Tags: Histol Histopathol Source Type: research

mTOR inhibition potentiates cytotoxicity of V γ4 γδ T cells via up-regulating NKG2D and TNF-α.
mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α. J Leukoc Biol. 2016 Nov;100(5):1181-1189 Authors: Cao G, Wang Q, Li G, Meng Z, Liu H, Tong J, Huang W, Liu Z, Jia Y, Wei J, Chi H, Yang H, Zhao L, Wu Z, Hao J, Yin Z Abstract γδ T cells play a critical role in early anti-tumor immunity and perform cytotoxicity via NKG2D for recognition and multiple cytotoxic factors for tumor killing. Recent studies have demonstrated pivotal roles of mTOR-mediated metabolism in the maturation, differentiation, and effector function of diverse immune cells, including DCs...
Source: Journal of Leukocyte Biology - October 31, 2016 Category: Hematology Authors: Cao G, Wang Q, Li G, Meng Z, Liu H, Tong J, Huang W, Liu Z, Jia Y, Wei J, Chi H, Yang H, Zhao L, Wu Z, Hao J, Yin Z Tags: J Leukoc Biol Source Type: research

Genome and Immune Profiling of Inflammatory Breast Cancer
Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-generation sequencing (NGS) and IHC were performed to identify activated pathways in IBC tumor tissues. siRNA studies examined the impact of IBC genomic variants in cellular models. IBC tumor tissues were further characterized for immune infiltration and immune checkpoint expression by IHC. Genomic analysis identified recurrent alterations in core biologic pathways, including ac...
Source: Molecular Cancer Therapeutics - July 4, 2016 Category: Cancer & Oncology Authors: Hamm, C. A., Moran, D., Rao, K., Trusk, P. B., Pry, K., Sausen, M., Jones, S., Velculescu, V. E., Cristofanilli, M., Bacus, S. Tags: Companion Diagnostics and Cancer Biomarkers Source Type: research

Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells
Abstract Adoptive cell therapy (ACT) employing ex vivo-generated tumor antigen-specific CD8+ T cells shows tumor efficacy when the transferred cells possess both effector and memory functions. New strategies based on understanding of mechanisms that balance CD8+ T cell differentiation toward effector and memory responses are highly desirable. Emerging information confirms a central role for antigen-induced metabolic reprogramming in CD8+ T cell differentiation and clonal expansion. The mitochondrial protein uncoupling protein 2 (UCP2) is induced by antigen stimulation of CD8+ T cells; however, its role in metaboli...
Source: Cancer Immunology, Immunotherapy - June 5, 2016 Category: Cancer & Oncology Source Type: research

mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α.
Abstract γδ T cells play a critical role in early anti-tumor immunity and perform cytotoxicity via NKG2D for recognition and multiple cytotoxic factors for tumor killing. Recent studies have demonstrated pivotal roles of mTOR-mediated metabolism in the maturation, differentiation, and effector function of diverse immune cells, including DCs, NK cells, CD4(+) T cell subsets, and CD8(+) T cells, but the role of mTOR signaling in γδ T cells is barely known. Here, we showed that suppressing mTOR signaling in in vitro-expanded Vγ4 γδ T cells via the mechanistic inhibitor rapamycin enhanced their cytotoxicity aga...
Source: Journal of Leukocyte Biology - June 1, 2016 Category: Hematology Authors: Cao G, Wang Q, Li G, Meng Z, Liu H, Tong J, Huang W, Liu Z, Jia Y, Wei J, Chi H, Yang H, Zhao L, Wu Z, Hao J, Yin Z Tags: J Leukoc Biol Source Type: research

Preparation of Antispermidine/Spermine-N1-Acetyltransferase Monoclonal Antibodies.
Authors: Chen Y, Zhang C Abstract Spermidine/spermine N1-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. Anti-SSAT antibodies (monoclonal antibodies [mAbs]) of high titer were prepared by immunizing BALB/c mice with multifocal intradermal injections and by fusing high-titer antibody-producing spleen cells with myeloma cells of SP2/0 origin. Four mAbs were selected for further characterization as classes and subclasses. Antibodies were produced by these three clones with high affinities ranging from 10(9) to 10(11) M(-1). The...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - May 28, 2016 Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

Lipidoid nanoparticle mediated silencing of Mcl-1 induces apoptosis in mantle cell lymphoma
In this study, we use potent lipidoid nanoparticles to deliver siRNA to silence Mcl-1 expression. Studies were conducted using two different mantle cell lymphoma cell lines, a normal (JeKo-1) and an aggressive (MAVER-1) line, to assess the ability of lipidoid nanoparticles to be used broadly in the treatment of mantle cell lymphoma. Mcl-1 mRNA silencing and protein knockdown was observed as early as one day after treatment and the lipidoid nanoparticles achieved sustained silencing of Mcl-1 mRNA for at least four days in both JeKo-1 and MAVER-1 cells. Eighty percent silencing was achieved at three days post-transfection in...
Source: Experimental Biology and Medicine - May 12, 2016 Category: Research Authors: Knapp, C. M., He, J., Lister, J., Whitehead, K. A. Tags: Original Research Source Type: research

Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide
In this study, we investigated the mechanisms through which Spry2 depletion by interferon (IFN) γ and Pg lipopolysaccharide (LPS) stimulation affected the physiology of macrophages in vitro. Transfection of macrophages with Spry2 small‐interfering RNA (siRNA) promoted the expression of genes characteristic of M2 alternative activated macrophages, induced interleukin (IL)‐10 expression, and enhanced arginase activity, even in cells stimulated with IFNγ and Pg LPS. In addition, we found that phosphoinositide 3‐kinase (PI3K) and AKT activation by Spry2 downregulation enhanced efferocytosis of apoptotic cells by increa...
Source: Immunity, Inflammation and Disease - February 26, 2016 Category: Allergy & Immunology Authors: Ryo Atomura, Terukazu Sanui, Takao Fukuda, Urara Tanaka, Kyosuke Toyoda, Takaharu Taketomi, Kensuke Yamamichi, Hajime Akiyama, Fusanori Nishimura Tags: Original Research Source Type: research