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Therapy: Immunotherapy
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Total 258 results found since Jan 2013.
Immunotherapy with a biologically active ICAM-1 mAb and an siRNA targeting TSHR in a BALB/c mouse model of Graves' disease
Conclusions These preliminary data suggest that both the biologically active ICAM-1 mAb and the siRNA targeting TSHR were effective. The ICAM-1 mAb exerted a better therapeutic effect than the siRNA targeting TSHR. Both treatments showed potential efficacy as novel treatments for GD and may therefore represent therapeutic options in addition to the existing drugs or interventions.PMID:34647608 | DOI:10.5603/EP.a2021.0087
Source: Endokrynologia Polska - October 14, 2021 Category: Endocrinology Authors: Xuan Wang Wei Liu Zhongying Rui Wei Zheng Jian Tan Ning Li Yang Yu Source Type: research
The multifaceted biology of PCSK9
This article reviews the discovery of PCSK9, its structure-function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating LDL-cholesterol (LDLc), via its ability to enhance the sorting and escort of the cell surface LDL receptor (LDLR) to lysosomes. This implicates the binding of the catalytic domain of PCSK9 to the EGF-A domain of the LDLR. This also requires the presence of the C-terminal Cys/His-rich domain (CHRD), its bind...
Source: Endocrine Reviews - October 9, 2021 Category: Endocrinology Authors: Nabil G Seidah Annik Prat Source Type: research
M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages
In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhibition of tumor growth by reprogramming TAMs into M1-like macrophages. M1 exosomes were transfected with NF-κB p50 siRNA and miR-511-3p to enhance M1 polarization and were surface-modified with IL4RPep-1, an IL4R-binding peptide, to target the IL4 receptor of TAMs (named IL4R-Exo(si/mi). IL4R-Exo(si/mi) were internalized and downregulated target gens in M2 macrophages and decreased M2 markers, while increasing M1 markers, more efficiently compared with untargeted and control peptide-labeled exosomes ...
Source: Biomaterials - September 24, 2021 Category: Materials Science Authors: Gowri Rangaswamy Gunassekaran Sri Murugan Poongkavithai Vadevoo Moon-Chang Baek Byungheon Lee Source Type: research
ASAP A siRNA-Assisted Assembly Strategy to Simultaneously Suppress “Self” and Upregulate “Eat-Me” Signals for Nanoenabled Chemo-Immunotherapy
ACS NanoDOI: 10.1021/acsnano.1c04458
Source: ACS Nano - September 20, 2021 Category: Nanotechnology Authors: Yuxi Zhang, Zhenghai Zhang, Senlin Li, Liang Zhao, Dongdong Li, Ziyang Cao, Xiaoding Xu, and Xianzhu Yang Source Type: research
O-145 Green Tea catechins EGCG and pro-drug of EGCG (Pro-EGCG) inhibit endometriosis through targeting molecules regulating macrophages and B cells
This study shows that macrophage and B cell could be potential therapeutic targets for treatment of endometriosis, which opens up new horizon for the novel immunotherapy for endometriosis.Trial registration numberNA
Source: Human Reproduction - August 6, 2021 Category: Reproduction Medicine Source Type: research
