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Therapy: Immunotherapy
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Total 258 results found since Jan 2013.
Targeting the chemokine ligand 2-chemokine receptor 2 axis provides the possibility of immunotherapy in chronic pain
Eur J Pharmacol. 2023 Mar 10:175646. doi: 10.1016/j.ejphar.2023.175646. Online ahead of print.ABSTRACTChronic pain affects patients' physical and psychological health and quality of life, entailing a tremendous public health challenge. Currently, drugs for chronic pain are usually associated with a large number of side effects and poor efficacy. Chemokines in the neuroimmune interface combine with their receptors to regulate inflammation or mediate neuroinflammation in the peripheral and central nervous system. Targeting chemokines and their receptor-mediated neuroinflammation is an effective means to treat chronic pain. I...
Source: European Journal of Pharmacology - March 12, 2023 Category: Drugs & Pharmacology Authors: Shan Liu Xiao-Bing Lan Miao-Miao Tian Chun-Hao Zhu Lin Ma Jia-Mei Yang Juan Du Ping Zheng Jian-Qiang Yu Ning Liu Source Type: research
T7 peptide-decorated exosome-based nanocarrier system for delivery of Galectin-9 siRNA to stimulate macrophage repolarization in glioblastoma
ConclusionOverall, T7-Exo/siGalectin-9 promotes macrophage repolarization and restricts the immunosuppression of GBM, thus providing novel insights into and drug delivery system of immunotherapy for GBM.Graphical abstract
Source: Journal of Neuro-Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research
DKK1 Affects Survival of Patients with Head and Neck Squamous Cell Carcinoma by Inducing Resistance to Radiotherapy and Immunotherapy
CONCLUSION: Our data show that DKK1 can affect both radiotherapy and immunotherapy in HNSC, suggesting that DKK1 can be a potential target for radioimmunology in HNSC.PMID:36690301 | DOI:10.1016/j.radonc.2023.109485
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - January 23, 2023 Category: Radiology Authors: Xinyu Ye Jingwen Liu Rencui Quan Yi Lu Jian Zhang Source Type: research
Retraction Note: Combination Cancer Immunotherapy with Dendritic Cell Vaccine and Nanoparticles Loaded with Interleukin-15 and Anti-beta-catenin siRNA Significantly Inhibits Cancer Growth and Induces Anti-Tumor Immune Response
Source: Pharmaceutical Research - December 7, 2022 Category: Drugs & Pharmacology Source Type: research
Extracellular vesicles (EVs) as diagnostic tools in the phenotypic determination of lung tumors
Immunotherapy has been one of the great advances in recent years for the treatment of advanced tumors. Our goal is to determine whether extracellular vesicles (EVs) are effective and appropriate tools for detecting and blocking immune checkpoints proteins (ICPs). We developed a method for tracing tumor content via an analysis of EVs surface makers in the bloodstream using the MAGPIX platform (Fig.1). As a proof of concept, we have developed the detection of 4 ICP-EV. We will use this technology to monitor the ICP-EV profile in patients undergoing immunotherapeutic treatment. Second, endothelial EVs will be used as drug car...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Cambier, M., Muller, F., Henket, M., Remacle, C., Guiot, J., Struman, I. Tags: 11.01 - Lung cancer Source Type: research
Lysosomal-mediated drug release and activation for cancer therapy and immunotherapy
Adv Drug Deliv Rev. 2022 Nov 23:114624. doi: 10.1016/j.addr.2022.114624. Online ahead of print.ABSTRACTThe development of carrier systems that are able to transport and release therapeutics to target cells is an emergent strategy to treat cancer; however, they following endocytosis are usually trapped in the endo/lysosomal compartments. The efficacy of drug conjugates and nanotherapeutics relies critically on their intracellular drug release ability, for which advanced systems responding to the unique lysosomal environment such as acidic pH and abundant enzymes (e.g. cathepsin B, sulfatase and β-glucuronidase) or equipped...
Source: Advanced Drug Delivery Reviews - November 26, 2022 Category: Drugs & Pharmacology Authors: Yinping Sun Yongjie Sha Guanhong Cui Fenghua Meng Zhiyuan Zhong Source Type: research
