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Specialty: Cardiology
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Total 800 results found since Jan 2013.
circSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway
CONCLUSIONS: The circSnd1/miR-485-3p/Olr1 axis participates in the formation and development of atherosclerosis by regulating inflammation and lipid transport.PMID:37426804 | PMC:PMC10329125 | DOI:10.1016/j.heliyon.2023.e17366
Source: Atherosclerosis - July 10, 2023 Category: Cardiology Authors: Lin Yang Yuhao Lin Chao Wang Pengcheng Fan Source Type: research
High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany
ConclusionIn this real-world patient population referred to German lipid clinics for elevated LDL-C levels, inclisiran demonstrated a high interindividual variability in LDL-C reductions. Further research is warranted to elucidate reasons for the interindividual variability in drug efficacy.Graphical abstract
Source: Clinical Research in Cardiology - July 9, 2023 Category: Cardiology Source Type: research
Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11
CONCLUSIONS: HSYA is expected to become an important health drug to prevent the occurrence and development of T2DM/AS.PMID:37410531 | DOI:10.1080/13880209.2023.2225543
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Jianjie Rong Chuanyong Li Qiang Zhang Guangfeng Zheng Weijian Fan Zhichang Pan Shuming Shi Source Type: research
Effect of Inclisiran on Haematological and Immunological Biomarkers: A Pooled Analysis of ORION-9, -10 and -11 Trial Data
Haematological and immunological adverse effects and significant injection-site adverse events (AEs) have been reported with some early generation anti-sense oligonucleotide (ribonucleic acid [RNA]-based) therapies, which required frequent dosing and had non-specific organ uptake. Inclisiran is a novel small interfering RNA (siRNA) therapy with twice-yearly dosing, and conjugated with trivalent N-Acetylgalactosamine (GalNAc) enabling targeted hepatic delivery. Here, we assessed the effects of inclisiran on haematological and immunological biomarkers.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: G. Watts, U. Landmesserr, L. Garcia Conde, S. Wright, F. Raal, W. Koenig, L. Leiter, G. Schwartz, D. Kallend, D. Lawrence, K. Ray Source Type: research
Pooled Safety Analysis of Inclisiran in 3,576 Patients With Approximately 10,000 Person Years of Exposure From Seven Trials
Inclisiran, an siRNA targeting PCSK9 mRNA, provides time-averaged reductions in LDL-C of ∼50% with twice-yearly administration after initial and three-month doses. Pooled data from seven completed or open-label extension trials provide additional data on the long-term safety of inclisiran.
Source: Heart, Lung and Circulation - July 1, 2023 Category: Cardiology Authors: A. Nelson, W. Wright, W. Koenig, U. Landmesser, L. Leiter, A. Lesogor, P. Maheux, F. Raal, G. Schwartz, C. Stratz, X. Zang, K. Ray Source Type: research
Role of Nuclear receptor subfamily 1 group D member 1 in the proliferation, migration of VSMC and vascular intimal hyperplasia
In conclusion, NR1D1 reduces vascular neointimal hyperplasia by suppressing proliferation and migration of VSMCs in an AKT/mTORC1-dependent manner.PMID:37381169 | DOI:10.1097/FJC.0000000000001446
Source: Atherosclerosis - June 29, 2023 Category: Cardiology Authors: Mingliang Wang Chenming Qiu Quanrong Pan Yongjian Yang Dachun Yang Xiongshan Sun Source Type: research
Naringenin ameliorates vascular senescence and atherosclerosis involving SIRT1 activation
CONCLUSIONS: Naringenin could ameliorate vascular senescence and atherosclerosis and the activation of SIRT1, with subsequent deacetylation and regulation of FOXO3a and PGC1α, is involved in this process.PMID:37343148 | DOI:10.1093/jpp/rgad053
Source: Atherosclerosis - June 21, 2023 Category: Cardiology Authors: Jie Wang Ruoman Wu Yiqiao Hua Shijia Ling Xiaole Xu Source Type: research
Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2
CONCLUSIONS: Findings from this study imply that TIE1 and TIE2, together with COUP-TFII, act in a synergistic manner to restrict sprouting angiogenesis during the development of venous system.PMID:37317851 | DOI:10.1161/ATVBAHA.122.318860
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 15, 2023 Category: Cardiology Authors: Xudong Cao Taotao Li Beibei Xu Kai Ding Weimin Li Bin Shen Man Chu Dengwen Zhu Li Rui Zhi Shang Xiao Li Yinyin Wang Shuyu Zheng Kari Alitalo Ganqiang Liu Jing Tang Yoshiaki Kubota Yulong He Source Type: research
