Filtered By:
Specialty: Cardiology
This page shows you your search results in order of date. This is page number 17.
Order by Relevance | Date
Total 800 results found since Jan 2013.
Cost-benefit analysis of new lipid-lowering agents
Herz. 2022 Apr 25. doi: 10.1007/s00059-022-05116-8. Online ahead of print.ABSTRACTPatients with atherosclerotic cardiovascular disease have a high risk for subsequent cardiovascular events despite optimal drug treatment including statins and ezetimibe. Dyslipidemia represents a central and direct cause of this, with a frequent failure to achieve the target values recommended in the guidelines. New lipid-lowering substances are increasingly becoming available for treatment of this residual risk. Due to their high cost, cost-effectiveness analyses are required in order to justify their use. Important variables when consideri...
Source: Herz - April 25, 2022 Category: Cardiology Authors: Christopher Blaum Natalie Arnold Christoph Waldeyer Source Type: research
Possible causes of atherosclerosis: lncRNA < em > COLCA1 < /em > induces oxidative stress in human coronary artery endothelial cells and impairs wound healing
CONCLUSIONS: OxLDL can up-regulate the expression of COLCA1 in HCAECs, which in turn affects the intracellular COLCA1/hsa-miR-371a-5p/SPP1 pathway to regulate the level of oxidative stress in cells. This in turn affects the level of apoptosis and wound healing ability, which causes cells to produce a continuous inflammatory response.PMID:35434044 | PMC:PMC9011302 | DOI:10.21037/atm-22-507
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Ming-Peng Li Zi-Chen Hao Meng-Qi Yan Chun-Li Xia Zhong-Hua Wang Ying-Qing Feng Source Type: research
Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects
This study aimed to determine the effectiveness of Isoflavones from semen sojae preparatum (ISSP) in inhibiting oxidative stress and its important molecular mechanisms through in vivo and in vitro experiments. ApoE-/- mice were used to establish atherosclerosis models through a high-fat diet, and endothelial cells were used to establish oxidative stress injury models through ox-LDL induction. The degree of oxidative stress damage was assessed by detecting changes in ET-1, LDH, SOD, and MDA indicators. It was observed that after ISSP treatment, the oxidative stress damage of mice and endothelial cells was improved. The Nrf2...
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Jinzhou Guo Jingxin Ma Kun Cai Haining Chen Ke Xie Binren Xu Desen Quan Jingyan Du Source Type: research
Possible causes of atherosclerosis: lncRNA < em > COLCA1 < /em > induces oxidative stress in human coronary artery endothelial cells and impairs wound healing
CONCLUSIONS: OxLDL can up-regulate the expression of COLCA1 in HCAECs, which in turn affects the intracellular COLCA1/hsa-miR-371a-5p/SPP1 pathway to regulate the level of oxidative stress in cells. This in turn affects the level of apoptosis and wound healing ability, which causes cells to produce a continuous inflammatory response.PMID:35434044 | PMC:PMC9011302 | DOI:10.21037/atm-22-507
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Ming-Peng Li Zi-Chen Hao Meng-Qi Yan Chun-Li Xia Zhong-Hua Wang Ying-Qing Feng Source Type: research
Isoflavones from Semen Sojae Preparatum Improve Atherosclerosis and Oxidative Stress by Modulating Nrf2 Signaling Pathway through Estrogen-Like Effects
This study aimed to determine the effectiveness of Isoflavones from semen sojae preparatum (ISSP) in inhibiting oxidative stress and its important molecular mechanisms through in vivo and in vitro experiments. ApoE-/- mice were used to establish atherosclerosis models through a high-fat diet, and endothelial cells were used to establish oxidative stress injury models through ox-LDL induction. The degree of oxidative stress damage was assessed by detecting changes in ET-1, LDH, SOD, and MDA indicators. It was observed that after ISSP treatment, the oxidative stress damage of mice and endothelial cells was improved. The Nrf2...
Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Jinzhou Guo Jingxin Ma Kun Cai Haining Chen Ke Xie Binren Xu Desen Quan Jingyan Du Source Type: research
Phosphatidylserine enhances anti-inflammatory effects of reconstituted HDL in macrophages via distinct intracellular pathways
FASEB J. 2022 May;36(5):e22274. doi: 10.1096/fj.201800810R.ABSTRACTPhosphatidylserine (PS) is a minor phospholipid constituent of high-density lipoprotein (HDL) that exhibits potent anti-inflammatory activity. It remains indeterminate whether PS incorporation can enhance anti-inflammatory effects of reconstituted HDL (rHDL). Human macrophages were treated with rHDL containing phosphatidylcholine alone (PC-rHDL) or PC and PS (PC/PS-rHDL). Interleukin (IL)-6 secretion and expression was more strongly inhibited by PC/PS-rHDL than PC-rHDL in both tumor necrosis factor (TNF)-α- and lipopolysaccharide (LPS)-stimulated macrophag...
Source: Atherosclerosis - April 13, 2022 Category: Cardiology Authors: Maryam Darabi Marie Lhomme Veronica D Dahik Isabelle Guillas Eric Frisdal Emilie Tubeuf Lucie Poupel Mili Patel Emmanuel L Gautier Thierry Huby Maryse Guerin Kerry-Anne Rye Philippe Lesnik Wilfried Le Goff Anatol Kontush Source Type: research
Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease
CONCLUSIONS: SLN360 induces a sustained reduction in serum Lp(a) levels in cynomolgus monkeys following subcutaneous dosing. SLN360 has potential to address the unmet need of Lp(a) reduction in cardiovascular diseases.PMID:35400495 | DOI:10.1016/j.atherosclerosis.2022.03.029
Source: Atherosclerosis - April 11, 2022 Category: Cardiology Authors: David A Rider Mona Eisermann Kathrin L öffler Manuela Aleku Daniel I Swerdlow Sibylle Dames Judith Hauptmann Eliot Morrison Marie Wikstr öm Lindholm Steffen Schubert Giles Campion Source Type: research
A novel anti-inflammatory role links the CARS2 locus to protection from coronary artery disease
CONCLUSIONS: These data highlight a novel anti-inflammatory novel role for CARS2 in human macrophages and SMCs that may underlie the protective effect of a common GWAS-identified variant.PMID:35381443 | DOI:10.1016/j.atherosclerosis.2022.03.024
Source: Atherosclerosis - April 5, 2022 Category: Cardiology Authors: Anh-Thu Dang Adam W Turner Paulina Lau Dhanuddara Mohottalage Yuet Kay Stephanie Fong Per Eriksson Lasse Folkersen Ljubica Matic Ulf Hedin S ébastien Soubeyrand Ruth McPherson Source Type: research
Pre-clinical assessment of SLN360, a novel siRNA targeting LPA, developed to address elevated lipoprotein (a) in cardiovascular disease
The LPA gene encodes apolipoprotein (a), a key component of Lp(a), a potent risk factor for cardiovascular disease with no specific pharmacotherapy. Here we describe the pharmacological data for SLN360, a GalNAc-conjugated siRNA targeting LPA, designed to address this unmet medical need.
Source: Atherosclerosis - April 1, 2022 Category: Cardiology Authors: David A. Rider, Mona Eisermann, Kathrin L öffler, Manuela Aleku, Daniel I. Swerdlow, Sibylle Dames, Judith Hauptmann, Eliot Morrison, Marie Wikström Lindholm, Steffen Schubert, Giles Campion Source Type: research
Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis
Int Heart J. 2022;63(2):327-337. doi: 10.1536/ihj.21-571.ABSTRACTEmerging literature suggests that pyroptosis plays a critical role in ischemia/hypoxia (I/R) -induced myocardial injury. Melatonin has been implicated in attenuating I/R-induced injury of cardiomyocytes. Nevertheless, whether melatonin inhibits I/R-induced pyroptosis of cardiomyocytes and the underlying molecular mechanisms remain unexploited.H9c2 cardiomyocytes were cultured under oxygen-glucose deprivation/reperfusion (OGD/R) condition to establish a myocardial pyroptosis model in vitro. OGD/R-induced pyroptosis was evaluated by CCK-8 assay, IL-1β and IL-1...
Source: International Heart Journal - March 31, 2022 Category: Cardiology Authors: Rui Chen Min Yang Source Type: research
