Possible causes of atherosclerosis: lncRNA < em > COLCA1 < /em > induces oxidative stress in human coronary artery endothelial cells and impairs wound healing

CONCLUSIONS: OxLDL can up-regulate the expression of COLCA1 in HCAECs, which in turn affects the intracellular COLCA1/hsa-miR-371a-5p/SPP1 pathway to regulate the level of oxidative stress in cells. This in turn affects the level of apoptosis and wound healing ability, which causes cells to produce a continuous inflammatory response.PMID:35434044 | PMC:PMC9011302 | DOI:10.21037/atm-22-507

Source: Atherosclerosis - April 18, 2022 Category: Cardiology Authors: Ming-Peng Li Zi-Chen Hao Meng-Qi Yan Chun-Li Xia Zhong-Hua Wang Ying-Qing Feng Source Type: research