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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Effect of FoxO1 on Cardiomyocyte Apoptosis and Inflammation in Viral Myocarditis via Modultion of the TLR4/NF- κB Signaling Pathway
Int Heart J. 2023;64(4):732-740. doi: 10.1536/ihj.22-627.ABSTRACTTo investigate the possible effect of FoxO on coxsackievirus B3 (CVB3) -induced cardiomyocyte inflammation and apoptosis via modulation of the TLR4/NF-κB signaling pathway.Viral myocarditis (VMC) models were establied via CVB3 infection both in vivo and in vitro. Western blotting was adopted to detect FoxO1 and TLR4 expressions in myocardial tissues and cells. Cardiomyocytes of suckling mouse were divided into the control, CVB3, CVB3 + pcDNA, CVB3 + pcDNA-FoxO1, CVB3 + TLR4 siRNA, and CVB3 + pcDNA-FoxO1 + TLR4 siRNA groups. Flow cytometry was employed to eva...
Source: International Heart Journal - July 30, 2023 Category: Cardiology Authors: Di-Di Tao Ya Li Xiao-Jiao Tian Xing-Juan Liao Zhong-Qin Yu Zhao-Yan Xiang Source Type: research
'Exciting' siRNA Therapy for Hypertension Passes First Hurdle
(MedPage Today) -- Patients with hypertension successfully dialed down their angiotensinogen levels and had lasting reductions in blood pressure (BP) following one injection of an investigational small interfering RNA (siRNA) therapy, according...
Source: MedPage Today Cardiovascular - July 19, 2023 Category: Cardiology Source Type: news
circSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway
CONCLUSIONS: The circSnd1/miR-485-3p/Olr1 axis participates in the formation and development of atherosclerosis by regulating inflammation and lipid transport.PMID:37426804 | PMC:PMC10329125 | DOI:10.1016/j.heliyon.2023.e17366
Source: Atherosclerosis - July 10, 2023 Category: Cardiology Authors: Lin Yang Yuhao Lin Chao Wang Pengcheng Fan Source Type: research
