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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Contribution of adipocyte Na/K-ATPase α1/CD36 signaling induced exosome secretion in response to oxidized LDL
DISCUSSION: In this work, we report that CD36, a scavenger receptor for oxidized LDL, formed a signaling complex with another membrane signal transducer Na/K-ATPase in adipocytes. The atherogenic oxidized LDL induced a pro-inflammatory response in in vitro differentiated mouse and human adipocytes and also stimulated the cells to secrete more exosomes. This was largely blocked by either CD36 knockdown using siRNA or pNaKtide, a peptide inhibitor of Na/K-ATPase signaling. These results showed a critical role of the CD36/Na/K-ATPase signaling complex in oxidized LDL-induced adipocyte exosome secretion. Moreover, by co-incuba...
Source: Atherosclerosis - May 14, 2023 Category: Cardiology Authors: Sneha S Pillai Duane G Pereira Jue Zhang Wenxin Huang Mirza Ahmar Beg Darcy A Knaack Bruno de Souza Goncalves Daisy Sahoo Roy L Silverstein Joseph I Shapiro Komal Sodhi Yiliang Chen Source Type: research
Diabetes is accompanied by secretion of pro-atherosclerotic exosomes from vascular smooth muscle cells
CONCLUSION: These data identify a novel paracrine signaling pathway that promotes the cardiovascular complications of diabetes mellitus.PMID:37179303 | DOI:10.1186/s12933-023-01833-4
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Heng Yu Hunter F Douglas Donald Wathieu Ryan A Braun Christine Edomwande Daniel J Lightell Thaidan Pham Natasha C Klingenberg Shelia Pugh Bishop Damir B Khismatullin T Cooper Woods Source Type: research
< em > SOX17 < /em > Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension
CONCLUSIONS: Common PAH risk variants upstream of the SOX17 promoter reduce endothelial SOX17 expression, at least in part, through differential binding of HOXA5 and ROR-α. Reduced SOX17 expression results in disturbed hPAEC function and PAH. Existing drug compounds can reverse the disturbed SOX17 pulmonary endothelial transcriptomic signature.PMID:37066790 | DOI:10.1161/CIRCULATIONAHA.122.061940
Source: Circulation - April 17, 2023 Category: Cardiology Authors: Rachel Walters Eleni Vasilaki Jurjan Aman Chien-Nien Chen Yukyee Wu Olin D Liang Ali Ashek Olivier Dubois Lin Zhao Farah Sabrin In ês Cebola Jorge Ferrer Nicholas W Morrell James R Klinger Martin R Wilkins Lan Zhao Christopher J Rhodes Source Type: research
Excessive exogenous cholesterol activating intestinal LXR α-ABCA1/G5/G8 signaling pathway can not reverse atherosclerosis in ApoE < sup > -/- < /sup > mice
CONCLUSION: In a high-cholesterol environment, the intestine promotes the excretion of cholesterol from the cell through the LXRα-ABCA1/G5/G8 pathway, reduces the intestinal intake of a variety of exogenous cholesterol, and reduces the risk of AS.PMID:37061692 | DOI:10.1186/s12944-023-01810-6
Source: Atherosclerosis - April 15, 2023 Category: Cardiology Authors: Xichao Yu Xue Ding Han Feng Yunhui Bi Yu Li Jinjun Shan Huimin Bian Source Type: research
Inclisiran-A Revolutionary Addition to a Cholesterol-Lowering Therapy
Int J Mol Sci. 2023 Apr 6;24(7):6858. doi: 10.3390/ijms24076858.ABSTRACTHypercholesterolemia plays a crucial role in the development of atherosclerosis, but it remains an undertreated and underdiagnosed disease. Taking into consideration the high prevalence of lipid disorders, long duration of the asymptomatic course of the disease, life-threatening complications resulting from inaccurate therapy, and stringent treatment goals concerning LDL cholesterol level in the prevention of cardiovascular events, novel lipid-lowering therapies have been introduced in the last few years. In this article, a drug belonging to the group ...
Source: Atherosclerosis - April 13, 2023 Category: Cardiology Authors: Adrianna Dec Aleksandra Niemiec Eliza Wojciechowska Mateusz Malig łówka Łukasz Bułdak Aleksandra Bo łdys Bogus ław Okopień Source Type: research
Buyang huanwu decoction inhibits diabetes-accelerated atherosclerosis via reduction of AMPK-Drp1-mitochondrial fission axis
CONCLUSION: The above findings support the conclusion that BYHWD suppresses diabetes-accelerated atherosclerosis by reducing mitochondrial fission through modulation of the AMPK/Drp1 pathway.PMID:37003404 | DOI:10.1016/j.jep.2023.116432
Source: Atherosclerosis - April 1, 2023 Category: Cardiology Authors: Wanyu Tong Ling Leng Yucheng Wang Jingwen Guo Felix Boahen Owusu Yue Zhang Fang Wang Ruiqiao Li Yuhong Li Yanxu Chang Yuefei Wang Qilong Wang Source Type: research
Role of triggering receptor expressed on myeloid cells-1 in the mechanotransduction signaling pathways that link low shear stress with inflammation
This study sought to investigate the role of triggering receptor expressed on myeloid cells-1 (TREM-1) in the mechanotransduction signaling pathways that link low shear stress with inflammation. Human coronary artery endothelial cells, human coronary artery smooth muscle cells, and THP-1 monocytes were co-cultured and exposed to varying endothelial shear stress (ESS) conditions: low (5 ± 3 dynes/cm2), medium (10 ± 3 dynes/cm2), and high (15 ± 3 dynes/cm2). We showed that low ESS increased the expression of TREM-1 by the cultured cells leading to increased production of inflammatory mediators and matrix-degrading enzymes...
Source: Atherosclerosis - March 22, 2023 Category: Cardiology Authors: Martin Liu Anastasios Nikolaos Panagopoulos Usama M Oguz Saurabhi Samant Charu Hasini Vasa Devendra K Agrawal Yiannis S Chatzizisis Source Type: research
Serum amyloid A and interleukin -1 β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway
CONCLUSIONS: SAA and IL-1β accelerated LDL transcytosis via the NF-κB/caveolin-1/cavin-1 axis.PMID:36935311 | DOI:10.1016/j.atherosclerosis.2023.03.004
Source: Atherosclerosis - March 19, 2023 Category: Cardiology Authors: Xiong Jia Zongtao Liu Yixuan Wang Geng Li Xiangli Bai Source Type: research
