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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway
ConclusionsMorphine may prevent I/R-induced myocardial mitochondrial damage by activating EGFR through δ-opioid receptors, in turn increasing RISK and SAFE pathway activity via intracellular ROS. Moreover, morphine may reduce myocardial injury by regulating autophagy but not apoptosis.
Source: Cardiovascular Drugs and Therapy - September 28, 2022 Category: Cardiology Source Type: research
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research
Identification of the Transcription Factor ATF3 as a Direct and Indirect Regulator of the LDLR
This study relied on two main resources: (1) genes with impact on atherosclerosis/CAD, and (2) liver-specific transcriptome analyses from human and mouse studies. The transcription factor activating transcription factor 3 (ATF3) was identified as a key regulator of a liver network relevant to atherosclerosis and linked to inflammation and cholesterol metabolism. ATF3 was predicted to be a direct and indirect (via MAF BZIP Transcription Factor F (MAFF)) regulator of low-density lipoprotein receptor (LDLR). Chromatin immunoprecipitation DNA sequencing (ChIP-seq) data from human liver cells revealed an ATF3 binding motif in t...
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Sabine Bauer Jana Eigenmann Yuqi Zhao Julia Fleig Johann S Hawe Calvin Pan Dario Bongiovanni Simon Wengert Angela Ma Aldons J Lusis Jason C Kovacic Johan L M Bj örkegren Lars Maegdefessel Heribert Schunkert Moritz von Scheidt Source Type: research
Transcription factor EB protects against endoplasmic reticulum stress in human coronary artery endothelial cells
Eur J Pharmacol. 2022 Sep 12:175274. doi: 10.1016/j.ejphar.2022.175274. Online ahead of print.ABSTRACTOxidative stress and endoplasmic reticulum (ER) stress promote atherogenesis while transcription factor EB (TFEB) inhibits atherosclerosis. Since reducing oxidative stress with antioxidants have failed to reduce atherosclerosis possibly because of aggravation of ER stress, we studied the effect of TFEB on ER stress in human coronary artery endothelial cells. ER stress was measured using the secreted alkaline phosphatase assay. Expression and phosphorylation of key mediators of unfolded protein response (UPR). TFEB, inosito...
Source: Atherosclerosis - September 15, 2022 Category: Cardiology Authors: Michael J Haas Victoria Feng Krista Gonzales Priyanka Bikkina Marie Angelica Landicho Arshag D Mooradian Source Type: research
Kv1.3 Channel Is Involved In Ox-LDL-induced Macrophage Inflammation Via ERK/NF- κB signaling pathway
In conclusion, Kv1.3 may be an indispensable membrane protein in ox-LDL-induced RAW264.7 macrophage inflammation in atherosclerosis through the ERK/NF-κB pathway.PMID:36100082 | DOI:10.1016/j.abb.2022.109394
Source: Atherosclerosis - September 13, 2022 Category: Cardiology Authors: Qiujie Zhang Lin Liu Yanyan Hu Lin Shen Li Li Yuanyuan Wang Source Type: research
mPR α and PR co-operate in progesterone inhibition of endothelial cell focal adhesion
J Mol Endocrinol. 2022 Sep 1:JME-22-0073. doi: 10.1530/JME-22-0073. Online ahead of print.ABSTRACTProgesterone causes vascular smooth muscle cell relaxation through membrane progesterone receptors (mPRs), which are members of the progestin and adipoQ receptor (PAQR) family, and nuclear PRs (nPRs). However, beneficial vascular effects of progesterone in preventing pre-atherosclerosis and the involvement of mPRs and nPRs remain unclear. The results show short- to long-term treatments with 100 nM progesterone (P4) and specific agonists for mPRs, OD 02-0, and nPRs, R5020, inhibited pre-atherosclerotic events in human umbilical...
Source: Atherosclerosis - September 13, 2022 Category: Cardiology Authors: Yefei Pang Peter Thomas Source Type: research
Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10
Contrast Media Mol Imaging. 2022 Aug 2;2022:1709325. doi: 10.1155/2022/1709325. eCollection 2022.ABSTRACTCardiovascular diseases could damage the heart and blood vessels, which cause mortality and morbidity. It is of great significance to explore targeted therapeutic approaches for atherosclerosis that is one of the most common vascular lesions and the main pathological basis of cardiovascular disease. However, the function of circRNA-0024103 in cardiovascular diseases is still not clear. Therefore, we aim to observe the effect of circRNA-0024103 modulation of miR-363/MMP-10 axis on biological behaviors such as proliferati...
Source: Atherosclerosis - August 22, 2022 Category: Cardiology Authors: Yunfei Tian Guofu Zheng Hailiang Xie Yi Guo Hui Zeng Youlin Fu Xiaochun Liu Source Type: research
Role of PCK2 in the proliferation of vascular smooth muscle cells in neointimal hyperplasia
Int J Biol Sci. 2022 Aug 8;18(13):5154-5167. doi: 10.7150/ijbs.75577. eCollection 2022.ABSTRACTVascular smooth muscle cell (VSMC) proliferation is a hallmark of neointimal hyperplasia (NIH) in atherosclerosis and restenosis post-balloon angioplasty and stent insertion. Although numerous cytotoxic and cytostatic therapeutics have been developed to reduce NIH, it is improbable that a multifactorial disease can be successfully treated by focusing on a preconceived hypothesis. We, therefore, aimed to identify key molecules involved in NIH via a hypothesis-free approach. We analyzed four datasets (GSE28829, GSE43292, GSE100927,...
Source: Atherosclerosis - August 19, 2022 Category: Cardiology Authors: Dai Sik Ko Junho Kang Hye Jin Heo Eun Kyoung Kim Kihun Kim Jin Mo Kang YunJae Jung Seung Eun Baek Yun Hak Kim Source Type: research
Fine-tuning of microglia polarization prevents diabetes-associated cerebral atherosclerosis
In this study, we showed that polarization of microglia, the resident macrophage in the central nervous system, appeared to play a critical role in the pathological progression of cerebral atherosclerosis. Microglia likely underwent an M2c-like polarization in an environment long exposed to high glucose. Experimental suppression of microglia M2c polarization was achieved through transduction of microglia with an adeno-associated virus (serotype AAV-PHP.B) carrying siRNA for interleukin-10 (IL-10) under the control of a microglia-specific TMEM119 promoter, which significantly attenuated diabetes-associated cerebral atherosc...
Source: Atherosclerosis - August 8, 2022 Category: Cardiology Authors: Xuan Zhu Pengfei Xing Ping Zhang Minmin Zhang Hongjian Shen Lei Chen Fang Shen Yi Jiang Hui Yuan Lei Zhang Jing Wang Xiongfeng Wu Yu Zhou Tao Wu Benqiang Deng Jianmin Liu Yongwei Zhang Pengfei Yang Source Type: research
VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis
CONCLUSION: These findings established a novel strategy for targeting the NLRP3 inflammasome using NLRP3 siRNA-PCLs to interrupt LDL transcytosis, representing a potential novel therapy for atherosclerosis.PMID:35917895 | DOI:10.1016/j.metabol.2022.155274
Source: Atherosclerosis - August 2, 2022 Category: Cardiology Authors: Xiong Jia Xiangli Bai Xiaoyan Yang Ling Wang Yajing Lu Lin Zhu Ying Zhao Wenzhuo Cheng Meng Shu Qiyong Mei Si Jin Source Type: research
