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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Galectin-3 induces vascular smooth muscle cells calcification via AMPK/TXNIP pathway
In this study, we evaluated the role of TXNIP in galectin-3-induced vascular calcification. A primary culture of mouse VSMCs was established by enzymatic digestion of aorta. Small interfering (si) RNA was used to knock down the expression of target gene. VSMCs were treated with 3-methyladenine (3-MA) or compound C respectively. Western blot was performed to detect the protein level in VSMCs, Alkaline phosphatase (ALP) and Alizarin red staining was used to observe calcium deposition. Dihydroethidium (DHE) staining was used to observe the reactive oxygen species (ROS) production. Here we showed that galectin-3 increased aort...
Source: Atherosclerosis - June 30, 2022 Category: Cardiology Authors: Lei Tian Yong Wang Ruiyan Zhang Source Type: research
LINC01013 Is a Determinant of Fibroblast Activation and Encodes a Novel Fibroblast-Activating Micropeptide
AbstractMyocardial fibrosis confers an almost threefold mortality risk in heart disease. There are no prognostic therapies and novel therapeutic targets are needed. Many thousands of unannotated small open reading frames (smORFs) have been identified across the genome with potential to produce micropeptides (< 100 amino acids). We sought to investigate the role of smORFs in myocardial fibroblast activation.Analysis of human cardiac atrial fibroblasts (HCFs) stimulated with profibrotic TGF β1 using RNA sequencing (RNA-Seq) and ribosome profiling (Ribo-Seq) identified long intergenic non-coding RNA LINC01013 as TGFβ1...
Source: Journal of Cardiovascular Translational Research - June 27, 2022 Category: Cardiology Source Type: research
Inhibition of S-adenosylhomocysteine hydrolase induces endothelial senescence via hTERT downregulation
CONCLUSIONS: SAHH inhibition induces endothelial senescence via downregulation of hTERT expression, which is associated with attenuated histone methylation over the hTERT promoter region.PMID:35753115 | DOI:10.1016/j.atherosclerosis.2022.06.002
Source: Atherosclerosis - June 26, 2022 Category: Cardiology Authors: Yiran You Xiaoyuan Sun Jinghe Xiao Yu Chen Xu Chen Juan Pang Jiaxin Mi Yi Tang Qiannan Liu Wenhua Ling Source Type: research
New Strategies for Lowering Low-Density Lipoprotein Cholesterol for Cardiovascular Disease Prevention
AbstractPurpose of ReviewThe primary and secondary prevention of atherosclerotic cardiovascular disease (ASCVD) relies on optimizing cardiovascular health and appropriate pharmacotherapy, a mainstay of which is low-density lipoprotein cholesterol (LDL-C) lowering. Typically, statin therapy remains the first-line approach. Advances in technology and understanding of lipid metabolism have facilitated the development of several novel therapeutic targets and medications within the last decade. This review focuses on medications recently approved by the US Food and Drug Administration (FDA) for the reduction of LDL-C and ASCVD ...
Source: Current Cardiovascular Risk Reports - June 25, 2022 Category: Cardiology Source Type: research
LXR α Regulates oxLDL-Induced Trained Immunity in Macrophages
Int J Mol Sci. 2022 May 31;23(11):6166. doi: 10.3390/ijms23116166.ABSTRACTReprogramming of metabolic pathways in monocytes and macrophages can induce a proatherosclerotic inflammatory memory called trained innate immunity. Here, we have analyzed the role of the Liver X receptor (LXR), a crucial regulator of metabolism and inflammation, in oxidized low-density lipoprotein (oxLDL)-induced trained innate immunity. Human monocytes were incubated with LXR agonists, antagonists, and oxLDL for 24 h. After five days of resting time, cells were restimulated with the TLR-2 agonist Pam3cys. OxLDL priming induced the expression of LXR...
Source: Atherosclerosis - June 10, 2022 Category: Cardiology Authors: Hannes M Findeisen Vivienne C Voges Laura C Braun Jannik Sonnenberg Dennis Schwarz Helena K örner Holger Reinecke Yahya Sohrabi Source Type: research
MDM2-Mediated Ubiquitination of RXR β Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis
In this study, we discovered that murine double minute-2 (MDM2) acts as an E3 ubiquitin ligase to target RXRβ for degradation. The result showed that MDM2 directly interacted with and regulated RXRβ protein stability. MDM2 promoted RXRβ poly-ubiquitination and degradation by proteasomes. Moreover, mutated MDM2 RING domain (C464A) or treatment with an MDM2 inhibitor targeting the RING domain of MDM2 lost the ability of MDM2 to regulate RXRβ protein expression and ubiquitination. Furthermore, treatment with MDM2 inhibitor alleviated oxidized low-density lipoprotein-induced mitochondrial damage, activation of TLR9/NF-κB ...
Source: Atherosclerosis - May 28, 2022 Category: Cardiology Authors: Yi Zeng Ji Cao Chun-Xia Li Chun-Yan Wang Ruo-Man Wu Xiao-Le Xu Source Type: research
S-adenosylhomocysteine induces cellular senescence in rat aorta vascular smooth muscle cells via NF- κB-SASP pathway
This study aimed to evaluate S-adenosyl-homocysteine (SAH) as a one-carbon metabolite that affects VSMCs senescence. We treated Rat Aorta Smooth Muscle Cells (RASMCs) with S-adenosylhomocysteine Hydrolase (SAHH) inhibitor, adenosine-2,3-dialdehyde (ADA) and SAHH siRNA to examine the effect of elevated SAH levels on RASMCs phenotypes. SAHH inhibition induced RASMCs senescence, as demonstrated by the manifestation of senescence-associated secretory phenotype in cells and induction of senescence in pre-senescent RASMCs. Furthermore, we found that SAHH inhibition induced CpG island demethylation in the promoter of NF-κB, a mo...
Source: Atherosclerosis - May 24, 2022 Category: Cardiology Authors: Jiaxin Mi Xu Chen Yi Tang Yiran You Qiannan Liu Jinghe Xiao Wenhua Ling Source Type: research
CircNMD3 relieves endothelial cell injury induced by oxidatively modified low-density lipoprotein through regulating miR-498/ BMP and activin membrane-bound inhibitor (BAMBI) axis
In this study, we showed the downregulation of circNMD3 in AS, and studied its role in the model of endothelial cell injury by proliferation and apoptosis assay, caspase 3 activity assay, and ELISA. We also identified and validated its downstream targets by luciferase reporter assay, RNA pull-down experiment, Western blot, and RT-qPCR. CircNMD3 overexpression or miR-498 knockdown could inhibit the ox-LDL (oxidatively modified low-density lipoprotein)-induced injury in HUVEC (human umbilical vein endothelial cells), while the co-transfection of miR-498 mimic or siRNA targeting BAMBI (BMP and activin membrane bound inhibitor...
Source: Atherosclerosis - May 23, 2022 Category: Cardiology Authors: Jian Xiu Zheng Yang Yanbo Sui Lin Zhang Yixing Zhou Source Type: research
SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia
CONCLUSIONS: SORBS2 regulates lipid-induced inflammation and foam cell formation, and is a potential therapeutic target for hypercholesterolemia.PMID:35590369 | DOI:10.1186/s12967-022-03381-z
Source: Atherosclerosis - May 19, 2022 Category: Cardiology Authors: Ming-Ming Liu Jia Peng Yuan-Lin Guo Cheng-Gang Zhu Na-Qiong Wu Rui-Xia Xu Qian Dong Chuan-Jue Cui Jian-Jun Li Source Type: research
