Inhibition of S-adenosylhomocysteine hydrolase induces endothelial senescence via hTERT downregulation

CONCLUSIONS: SAHH inhibition induces endothelial senescence via downregulation of hTERT expression, which is associated with attenuated histone methylation over the hTERT promoter region.PMID:35753115 | DOI:10.1016/j.atherosclerosis.2022.06.002

Source: Atherosclerosis - June 26, 2022 Category: Cardiology Authors: Yiran You Xiaoyuan Sun Jinghe Xiao Yu Chen Xu Chen Juan Pang Jiaxin Mi Yi Tang Qiannan Liu Wenhua Ling Source Type: research