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Specialty: Cardiology
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Total 800 results found since Jan 2013.
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding
In conclusion, miR-145 alleviates phenotype transition from contractile to synthetic type via ADAM17-mediated ACE2 shedding in VSMCs and retains the activation of ACE2-Ang-(1-7)-Mas axis, which may benefit the vascular structural remodeling in the metabolic hypertension.PMID:37521117 | PMC:PMC10374374 | DOI:10.1155/2023/9497716
Source: International Journal of Hypertension - July 31, 2023 Category: Cardiology Authors: Juan Wen Baiyi Tang Lan Guo Wei Chen Xiaohong Tang Source Type: research
Promising novel siRNA for the treatment of hypertension
Nature Reviews Cardiology, Published online: 31 July 2023; doi:10.1038/s41569-023-00916-9Patients with hypertension who receive a single subcutaneous dose of zilebesiran, a novel small-interfering RNA that inhibits hepatic angiotensinogen synthesis, have reductions in serum angiotensinogen levels and 24-h ambulatory blood pressure that last for up to 24 weeks, according to a phase I study.
Source: Nature Reviews Cardiology - July 31, 2023 Category: Cardiology Authors: Irene Fern ández-Ruiz Source Type: research
Effect of FoxO1 on Cardiomyocyte Apoptosis and Inflammation in Viral Myocarditis via Modultion of the TLR4/NF- κB Signaling Pathway
Int Heart J. 2023;64(4):732-740. doi: 10.1536/ihj.22-627.ABSTRACTTo investigate the possible effect of FoxO on coxsackievirus B3 (CVB3) -induced cardiomyocyte inflammation and apoptosis via modulation of the TLR4/NF-κB signaling pathway.Viral myocarditis (VMC) models were establied via CVB3 infection both in vivo and in vitro. Western blotting was adopted to detect FoxO1 and TLR4 expressions in myocardial tissues and cells. Cardiomyocytes of suckling mouse were divided into the control, CVB3, CVB3 + pcDNA, CVB3 + pcDNA-FoxO1, CVB3 + TLR4 siRNA, and CVB3 + pcDNA-FoxO1 + TLR4 siRNA groups. Flow cytometry was employed to eva...
Source: International Heart Journal - July 30, 2023 Category: Cardiology Authors: Di-Di Tao Ya Li Xiao-Jiao Tian Xing-Juan Liao Zhong-Qin Yu Zhao-Yan Xiang Source Type: research
Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis
CONCLUSIONS: SAHH inhibition epigenetically upregulates Drp1 expression through repressing DNA methylation in endothelial cells, leading to vascular senescence and atherosclerosis. These results identify SAHH or SAH as a potential therapeutic target for vascular senescence and cardiovascular diseases.PMID:37517319 | DOI:10.1016/j.redox.2023.102828
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Yiran You Xu Chen Yu Chen Juan Pang Qian Chen Qiannan Liu Hongliang Xue Yupeng Zeng Jinghe Xiao Jiaxin Mi Yi Tang Wenhua Ling Source Type: research
