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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Silencing of Fli1 gene mimics effects of preeclampsia and induces collagen synthesis in human umbilical arteries
CONCLUSIONS: Our results show that after silencing the Fli1 gene in healthy human umbilical arteries a new phenotype emerges which is typical for preeclampsia and is associated with vascular fibrosis.PMID:35569064 | DOI:10.1093/ajh/hpac065
Source: American Journal of Hypertension - May 15, 2022 Category: Cardiology Authors: Natalia I Agalakova Vitaly A Reznik Ivan A Ershov Ekaterina A Lupanova Olga V Nadei Dmitry O Ivanov C David Adair Alexei Y Bagrov Source Type: research
The enigmatic role of VCAM-1 expressed by macrophages in mitochondrial metabolism and atherosclerosis
CONCLUSION: We conclude that macrophage-specific VCAM-1 augments mitochondrial biogenesis and DNA oxidation via Cmpk2. Oxidized mitochondrial DNA in plaque macrophages increases inflammation via Sting, resulting in exacerbation of atherosclerosis.PMID:35557156 | DOI:10.1096/fasebj.2022.36.S1.R6141
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Niranjana Natarajan Jonathan Florentin Scott P O'Neil Lee L Ohayon Partha Dutta Source Type: research
A Transcriptional Regulation Bioinformatics Pipeline to Predict Co-Regulated Genes in Vascular Smooth Muscle Cell Phenotypic Transitions During Atherosclerosis
This study proposes a novel systems biology pipeline that integrates experimental and computational tools with large datasets measuring the transcriptomes and epigenomes of phenotypically transitioning VSMCs. Our pipeline allows users to identify candidate transcription factors that co-regulate mouse or human gene sets controlling specific VSMC phenotypic transitions during atherosclerosis. The computational algorithms developed in this workflow integrate an array of publicly available databases, such as the Ensembl genome database and the JASPAR transcription factor database. To demonstrate the translational potential of ...
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Mahima S Reddy Vlad Serbulea Sohel Shamsuzzaman Anita Salamon Rupa Tripathi Clint Miller Giuseppe Mocci Johan Bj örkegren Gary Owens Source Type: research
Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis
This study aims to verify the hypothesis that CREB promotes the expression of periostin in MI-induced myocardial fibrosis. To test this hypothesis, primary rat cardiac fibroblasts were cultured and rat model of MI was established. The level of myocardial fibrosis post-MI was identified by histological staining. The expressions of CREB and periostin were detected through western blot and reverse transcription quantity polymerase chain reaction. The upregulation and downregulation of CREB and periostin were established by plasmid, small interfere RNA (siRNA), and lentivirus, respectively. High levels of CREB and periostin we...
Source: Journal of Cardiovascular Pharmacology - May 1, 2022 Category: Cardiology Tags: Original Article Source Type: research
Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation
Cell. 2022 Apr 29:S0092-8674(22)00443-3. doi: 10.1016/j.cell.2022.04.005. Online ahead of print.ABSTRACTEpidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ9-tetrahydrocannabinol (Δ9-THC), the psychoactive component of marijuana, binds to cannabinoid receptor 1 (CB1/CNR1) in the vasculature and is implicated in CVD. A UK Biobank analysis found that cannabis was an risk factor for CVD. We found that marijuana smoking activated inflammatory cytokines implicated in CVD. In silico virtual screening identified genistein, a soybean iso...
Source: Atherosclerosis - April 30, 2022 Category: Cardiology Authors: Tzu-Tang Wei Mark Chandy Masataka Nishiga Angela Zhang Kaavya Krishna Kumar Dilip Thomas Amit Manhas Siyeon Rhee Johanne Marie Justesen Ian Y Chen Hung-Ta Wo Saereh Khanamiri Johnson Y Yang Frederick J Seidl Noah Z Burns Chun Liu Nazish Sayed Jiun-Jie Shi Source Type: research
MEK1/2 inhibitor inhibits neointima formation by activating miR-126-3p/ C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 4 (CXCR4) axis
Bioengineered. 2022 Apr;13(4):11214-11227. doi: 10.1080/21655979.2022.2063496.ABSTRACTEndothelial dysfunction is an initial and essential step in vascular-remodeling diseases, including atherosclerosis and neointima formation. During vascular remodeling, activated endothelial cells can release pro-inflammatory factors that promote phenotypic switching of vascular smooth muscle cells (VSMCs) to the proliferative phenotype. We previously reported that MEK1/2 inhibitor, U0126, has a protective effect on the development of atherosclerosis and vascular calcification. However, the effect of MEK1/2 inhibitors on neointimal format...
Source: Atherosclerosis - April 29, 2022 Category: Cardiology Authors: Yali Yan Mengmeng Zhu Jialing Ma Xiaoyu He Xiaoxiao Yang Hongmei Xu Meixiu Jiang Shuang Zhang Yajun Duan Jihong Han Yuanli Chen Source Type: research
Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles on Atherosclerosis-Induced Vascular Dysfunction and Its Key Molecular Players
Front Cell Dev Biol. 2022 Mar 18;10:817180. doi: 10.3389/fcell.2022.817180. eCollection 2022.ABSTRACTAtherosclerosis is a progressive, chronic inflammatory disease of the large arteries caused by the constant accumulation of cholesterol, followed by endothelial dysfunction and vascular inflammation. We hypothesized that delivery of extracellular vesicles (EVs), recognized for their potential as therapeutic targets and tools, could restore vascular function in atherosclerosis. We explored by comparison the potential beneficial effects of EVs from subcutaneous adipose tissue stem cells (EVs (ADSCs)) or bone marrow mesenchyma...
Source: Atherosclerosis - April 28, 2022 Category: Cardiology Authors: Ioana Karla Comari ţa Alexandra V îlcu Alina Constantin Anastasia Procopciuc Florentina Safciuc Nicoleta Alexandru Emanuel Dragan Miruna Nemecz Alexandru Filippi Leona Chi ţoiu Mihaela Gherghiceanu Adriana Georgescu Source Type: research
Capmatinib suppresses LPS-induced interaction between HUVECs and THP-1 monocytes through suppression of inflammatory responses
CONCLUSION: These findings imply that CAP improves inflamed endothelial-monocyte adhesion via a PPAR/IL-10-dependent pathway. The current study provides in vitro evidence for a therapeutic approach for treating atherosclerosis.PMID:35483573 | DOI:10.1016/j.bj.2022.04.005
Source: Atherosclerosis - April 28, 2022 Category: Cardiology Authors: Hyung Sub Park A M Abd El-Aty Ji Hoon Jeong Taeseung Lee Tae Woo Jung Source Type: research
Cost-benefit analysis of new lipid-lowering agents
Herz. 2022 Apr 25. doi: 10.1007/s00059-022-05116-8. Online ahead of print.ABSTRACTPatients with atherosclerotic cardiovascular disease have a high risk for subsequent cardiovascular events despite optimal drug treatment including statins and ezetimibe. Dyslipidemia represents a central and direct cause of this, with a frequent failure to achieve the target values recommended in the guidelines. New lipid-lowering substances are increasingly becoming available for treatment of this residual risk. Due to their high cost, cost-effectiveness analyses are required in order to justify their use. Important variables when consideri...
Source: Atherosclerosis - April 25, 2022 Category: Cardiology Authors: Christopher Blaum Natalie Arnold Christoph Waldeyer Source Type: research
