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Specialty: Cardiology
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Total 800 results found since Jan 2013.
EVA1A (Eva-1 Homolog A) Promotes Endothelial Apoptosis and Inflammatory Activation Under Disturbed Flow Via Regulation of Autophagy
CONCLUSIONS: We identified EVA1A as a novel flow-sensitive gene that mediates the effects of proatherogenic DF on EC dysfunction by regulating autophagy.PMID:36794585 | DOI:10.1161/ATVBAHA.122.318110
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 16, 2023 Category: Cardiology Authors: Lindsay Canham Sam Sendac Mannekomba R Diagbouga Elena Wolodimeroff Daniela Pirri Blanca Tardajos Ayllon Shuang Feng Celine Souilhol Timothy J A Chico Paul C Evans Jovana Serbanovic-Canic Source Type: research
Ant-Neointimal Formation Effects of SLC6A6 in Preventing Vascular Smooth Muscle Cell Proliferation and Migration via Wnt/ β-Catenin Signaling
In this study, mRNA and protein levels of SLC6A6 were examined using models of VSMC phenotype switching in vivo and in vitro and human artery samples with or without atherosclerosis. SLC6A6 gain- and loss-of-function approaches were performed by adenovirus infection or small interfering RNA (siRNA) transfection, respectively. Reactive oxygen species (ROS), proliferation, migration, and phenotype-related proteins of VSMCs were measured. Vascular stenosis rate and related genes were assessed in a rat vascular balloon injury model overexpressing SLC6A6. SLC6A6 was downregulated in dedifferentiated VSMCs, atherosclerotic vascu...
Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Zhihua Rong Fengshi Li Rui Zhang Shuai Niu Xiao Di Leng Ni Changwei Liu Source Type: research
Recombinant Adenovirus siRNA Knocking Down the Ndufs4 Gene Alleviates Myocardial Apoptosis Induced by Oxidative Stress Injury
In conclusion, we successfully constructed Ndufs4 siRNA recombinant adenovirus; furthermore, the downexpression of the Ndufs4 gene may alleviate H2O2-induced H9c2 cell apoptosis.PMID:36741296 | PMC:PMC9897913 | DOI:10.1155/2023/8141129
Source: Cardiology Research and Practice - February 6, 2023 Category: Cardiology Authors: Beibei Wang Jinsheng Zhang Aijun Xu Source Type: research
Gene editing for dyslipidemias: New tools to "cut" lipids
Atherosclerosis. 2023 Jan 14:S0021-9150(23)00011-4. doi: 10.1016/j.atherosclerosis.2023.01.010. Online ahead of print.ABSTRACTEffective lipid lowering therapies are essential for the prevention of atherosclerosis and cardiovascular disease. Available treatments have evolved in both their efficacy and their frequency of administration, and currently include monoclonal antibodies, antisense oligonucleotides and siRNA approaches. However, an unmet need remains for more effective and long-lasting therapeutics. Gene editing permanently alters endogenous gene expression and has the potential to revolutionize disease treatment. D...
Source: Atherosclerosis - February 1, 2023 Category: Cardiology Authors: Sylvia Stankov Marina Cuchel Source Type: research
Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease
CONCLUSIONS: The miRNA transcriptomic signature of circulating sEVs uncovered their pathologic role, devoid of the calcification-protective miRNAs that target VEGFA signaling in CKD-driven vascular calcification. These sEV-propagated miRNAs are potential biomarkers and therapeutic targets for vascular calcification.PMID:36700539 | DOI:10.1161/CIRCRESAHA.122.321939
Source: Circulation Research - January 26, 2023 Category: Cardiology Authors: Takaaki Koide Shintaro Mandai Reo Kitaoka Hisazumi Matsuki Motoko Chiga Kouhei Yamamoto Kotaro Yoshioka Yohsuke Yagi Soichiro Suzuki Tamami Fujiki Fumiaki Ando Takayasu Mori Koichiro Susa Soichiro Iimori Shotaro Naito Eisei Sohara Tatemitsu Rai Takanori Y Source Type: research
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
In conclusion,LINC00607 is an endothelial-enriched lncRNA that maintains ERG target gene transcription by interacting with the chromatin remodeler BRG1 to ultimately mediate angiogenesis.
Source: Basic Research in Cardiology - January 26, 2023 Category: Cardiology Source Type: research
