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Specialty: Cardiology
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Total 800 results found since Jan 2013.
Salvianolic Acid B Suppresses ER Stress-Induced NLRP3 Inflammasome and Pyroptosis via the AMPK/FoxO4 and Syndecan-4/Rac1 Signaling Pathways in Human Endothelial Progenitor Cells
Oxid Med Cell Longev. 2022 Mar 17;2022:8332825. doi: 10.1155/2022/8332825. eCollection 2022.ABSTRACTMounting evidence demonstrates uncontrolled endoplasmic reticulum (ER) stress responses can activate the inflammasome, which generally results in endothelial dysfunction, a major pathogenetic factor of chronic inflammatory diseases such as atherosclerosis. Salvianolic acid B (SalB), produced by Radix Salviae, exerts antioxidative and anti-inflammatory activities in multiple cell types. However, SalB's effects on ER stress-related inflammasome and endothelial dysfunction remain unknown. Here, we showed SalB substantially abro...
Source: Atherosclerosis - March 28, 2022 Category: Cardiology Authors: Yubo Tang Qingde Wa Longyun Peng Yifan Zheng Jie Chen Xiao Chen Xuenong Zou Huangxuan Shen Shuai Huang Source Type: research
Valproic acid decreases vascular smooth muscle cell proliferation via protein phosphatase 2A-mediated p70 S6 kinase inhibition
In conclusion, our results demonstrate that VPA decreased cell proliferation via PP2A-mediated inhibition of p-p70S6K-Thr389 in basal and PDGF-stimulated VSMCs. The results suggest that VPA could be used in the treatment and prevention of atherosclerosis and in-stent restenosis.PMID:35339758 | DOI:10.1016/j.bbrc.2022.03.100
Source: Atherosclerosis - March 27, 2022 Category: Cardiology Authors: Hansol Lee Yun-Jin Hwang Jung-Hyun Park Du-Hyong Cho Source Type: research
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway
In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endothelial cell injury and atherosclerosis in apoE-/- mice. Our results showedthat both dihydrohomoplantagin and homoplantaginin inhibited apoptosis and the increased level of ICAM-1 and VCAM-1 in oxLDL-stimulated HUVECs and the plaque endothelium of apoE-/- mice. Additionally, both of them restricted atherosclerosis development of apoE-/- mice. Mechanistic studies showed that oxLDL-induced the increase in ROS production, phosphorylation of ERK and nuclear translocation of NF-κB in HUVECs was significantly i...
Source: Atherosclerosis - March 26, 2022 Category: Cardiology Authors: Ning Meng Kai Chen Yanhong Wang Jiarong Hou Wenhui Chu Shan Xie Fengying Yang Chunhui Sun Source Type: research
Nrf2 deficiency attenuates atherosclerosis by reducing LOX-1-mediated proliferation and migration of vascular smooth muscle cells
CONCLUSIONS: Together, our data indicate that Nrf2 insufficiency is linked to attenuation of atherosclerosis, and could diminish the pathological process by blunting LOX-1-mediated proliferation and migration of VSMCs.PMID:35299056 | DOI:10.1016/j.atherosclerosis.2022.02.025
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Hongliang Li Wenwen Zhuang Tianqing Xiong Won Sun Park Song Zhang Yiwen Zha Jiali Yao Fangfang Wang Yongqi Yang Yingrui Chen Linqian Cai Ling Ling Duonan Yu Jingyan Liang Source Type: research
CCAAT/Enhancer-Binding Protein Alpha Is a Novel Regulator of Vascular Smooth Muscle Cell Osteochondrogenic Transition and Vascular Calcification
CONCLUSION: Findings in this study indicate that C/EBPα is a key regulator of the osteochondrogenic transdifferentiation of VSMCs and vascular calcification, which may represent a novel therapeutic target for vascular calcification.PMID:35295585 | PMC:PMC8918665 | DOI:10.3389/fphys.2022.755371
Source: Atherosclerosis - March 17, 2022 Category: Cardiology Authors: Pengyuan Chen Wanzi Hong Ziying Chen Flora Gordillo-Martinez Siying Wang Hualin Fan Yuanhui Liu Yining Dai Bo Wang Lei Jiang Hongjiao Yu PengCheng He Source Type: research
HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells
Cell Death Discov. 2022 Mar 12;8(1):112. doi: 10.1038/s41420-022-00906-9.ABSTRACTHistone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily, participates in various cardiovascular diseases. Recent evidence showed that pyroptosis was a form of inflammatory programmed cell death and is critical for atherosclerosis (AS). However, little is known about the effect of HDAC11 on endothelial cell pyroptosis in AS. Thus, this study aims to investigate the role of HDAC11 in vascular endothelial cell pyroptosis and its molecular mechanism. Firstly, we found that HDAC11 expression was up-regulated and pyroptosis occ...
Source: Atherosclerosis - March 13, 2022 Category: Cardiology Authors: Feng Yao Zhen Jin Zihan Zheng Xiaohan Lv Lingxuan Ren Jianjun Yang Danli Chen Bo Wang Wei Yang Lifang Chen Weirong Wang Jianli Gu Rong Lin Source Type: research
Renoprotective Effect of KLF2 on Glomerular Endothelial Dysfunction in Hypertensive Nephropathy
Cells. 2022 Feb 22;11(5):762. doi: 10.3390/cells11050762.ABSTRACTKruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is associated with hypertension and is a predictor of atherosclerosis development and cardiovascular events. Here, we investigated the role of KLF2 in hypertensive nephropathy by regulating KLF2 expression in human primary glomerular endothelial cells (hPGECs) and evaluating this expression in the kidney tissues of a 5/6 nephrectomy mouse model as well as patients with hypertension. Hypertension-mimicking devices and KLF2 siRNA were used to downregulate KLF2 expression...
Source: Atherosclerosis - March 10, 2022 Category: Cardiology Authors: Eunjin Bae Mi-Yeon Yu Jong-Joo Moon Ji-Eun Kim Saram Lee Sang-Woong Han Dong-Jun Park Yon-Su Kim Seung-Hee Yang Source Type: research
DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction
Eur J Pharm Sci. 2022 Mar 5:106164. doi: 10.1016/j.ejps.2022.106164. Online ahead of print.ABSTRACTAtherosclerosis is the common pathophysiological foundation of ischaemic stroke and myocardial ischaemia. Oxidative stress is intricately related to the progress of atherosclerosis. DL-3-n-butylphthalide (NBP) is a synthesized raceme of L-3-n-butylphthalide that is first isolated from celery. As a neuroprotective agent, NBP also exhibits potent antioxidative activity. Our research aimed to evaluate the effect of NBP on atherosclerosis and to explore the underlying antioxidative mechanisms and targets. Firstly, we detected the...
Source: Atherosclerosis - March 8, 2022 Category: Cardiology Authors: Jibo Han Xiaowen Shi Jiajun Xu Wante Lin Yanghao Chen Bingjiang Han Yi Wang Jianjiang Xu Source Type: research
Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization
CONCLUSIONS: The above observations clearly reveal that PLCβ3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.PMID:35236105 | DOI:10.1161/ATVBAHA.121.317182
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 3, 2022 Category: Cardiology Authors: Raj Kumar Gadiparthi N Rao Source Type: research
