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Specialty: Cardiology
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Total 800 results found since Jan 2013.
SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment
In this study, we found that SRC-3-/-ApoE-/- mice have reduced atherosclerotic lesions and necrotic areas in their aortas and aortic roots compared with SRC-3+/+ApoE-/- mice after Western diet (WD) feeding for 12 weeks. RNA-Seq and Western blot analyses of the aorta revealed that SRC-3 was required for maintaining the expression of ICAM-1, which was required for macrophage recruitment and atherosclerosis development. siRNA-mediated knockdown of SRC-3 in endothelial cells significantly reduced WD-induced atherosclerotic plaque formation. Additionally, treatment of ApoE-/- mice with SRC-3 inhibitor bufalin prevented atherosc...
Source: Atherosclerosis - October 20, 2022 Category: Cardiology Authors: Wenbo Chen Wuyang Zheng Shixiao Liu Qiang Su Kangxi Ding Ziguan Zhang Ping Luo Yong Zhang Jianming Xu Chundong Yu Weihua Li Zhengrong Huang Source Type: research
BRD4 Silencing Protects Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting TLR4/NF- < em > κ < /em > B and Activating Nrf2-HO-1 Pathways
CONCLUSION: Our results speculate that the BRD4/TLR4 axis might be a promising strategy for treating cardiovascular diseases with cardiac hypertrophy, including HF.PMID:36247184 | PMC:PMC9553838 | DOI:10.1155/2022/8372707
Source: Cardiology Research and Practice - October 17, 2022 Category: Cardiology Authors: Ming Fang Jun Luo Xi Zhu Yingbiao Wu Xinming Li Source Type: research
Sox13 is a novel flow-sensitive transcription factor that prevents inflammation by repressing chemokine expression in endothelial cells
Front Cardiovasc Med. 2022 Sep 30;9:979745. doi: 10.3389/fcvm.2022.979745. eCollection 2022.ABSTRACTAtherosclerosis is a chronic inflammatory disease and occurs preferentially in arterial regions exposed to disturbed blood flow (d-flow) while the stable flow (s-flow) regions are spared. D-flow induces endothelial inflammation and atherosclerosis by regulating endothelial gene expression partly through the flow-sensitive transcription factors (FSTFs). Most FSTFs, including the well-known Kruppel-like factors KLF2 and KLF4, have been identified from in vitro studies using cultured endothelial cells (ECs). Since many flow-sen...
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Catherine Demos Janie Johnson Aitor Andueza Christian Park Yerin Kim Nicolas Villa-Roel Dong-Won Kang Sandeep Kumar Hanjoong Jo Source Type: research
BRD4 Silencing Protects Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting TLR4/NF- < em > κ < /em > B and Activating Nrf2-HO-1 Pathways
CONCLUSION: Our results speculate that the BRD4/TLR4 axis might be a promising strategy for treating cardiovascular diseases with cardiac hypertrophy, including HF.PMID:36247184 | PMC:PMC9553838 | DOI:10.1155/2022/8372707
Source: Cardiology Research and Practice - October 17, 2022 Category: Cardiology Authors: Ming Fang Jun Luo Xi Zhu Yingbiao Wu Xinming Li Source Type: research
Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy
Int J Mol Sci. 2022 Sep 22;23(19):11174. doi: 10.3390/ijms231911174.ABSTRACTIncreased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group wit...
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Viorel I Suica Elena Uyy Luminita Ivan Raluca M Boteanu Aurel Cerveanu-Hogas Rune Hansen Felicia Antohe Source Type: research
Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1
Cells. 2022 Sep 28;11(19):3044. doi: 10.3390/cells11193044.ABSTRACTThe transport of low-density lipoprotein (LDL) through the endothelium is a key step in the development of atherosclerosis, but it is notorious that phenotypic differences exist between endothelial cells originating from different vascular beds. Endothelial cells forming the blood-brain barrier restrict paracellular and transcellular passage of plasma proteins. Here, we systematically compared brain versus aortic endothelial cells towards their interaction with LDL and the role of proteins known to regulate the uptake of LDL by endothelial cells. Both brain...
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Sofia Kakava Eveline Schlumpf Grigorios Panteloglou Flavia Tellenbach Arnold von Eckardstein Jerome Robert Source Type: research
Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis
CONCLUSIONS: These results revealed a new m6A epigenetic method to regulate the progress of atherosclerosis, which suggest approaches for potential therapeutic interventions that target METTL3 for the prevention and treatment of coronary artery diseases.PMID:36230944 | DOI:10.3390/cells11192980
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Yaqing Zhou Rongli Jiang Yali Jiang Yahong Fu Yerbolat Manafhan Jinfu Zhu Enzhi Jia Source Type: research
Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy
Int J Mol Sci. 2022 Sep 22;23(19):11174. doi: 10.3390/ijms231911174.ABSTRACTIncreased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group wit...
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Viorel I Suica Elena Uyy Luminita Ivan Raluca M Boteanu Aurel Cerveanu-Hogas Rune Hansen Felicia Antohe Source Type: research
Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1
Cells. 2022 Sep 28;11(19):3044. doi: 10.3390/cells11193044.ABSTRACTThe transport of low-density lipoprotein (LDL) through the endothelium is a key step in the development of atherosclerosis, but it is notorious that phenotypic differences exist between endothelial cells originating from different vascular beds. Endothelial cells forming the blood-brain barrier restrict paracellular and transcellular passage of plasma proteins. Here, we systematically compared brain versus aortic endothelial cells towards their interaction with LDL and the role of proteins known to regulate the uptake of LDL by endothelial cells. Both brain...
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Sofia Kakava Eveline Schlumpf Grigorios Panteloglou Flavia Tellenbach Arnold von Eckardstein Jerome Robert Source Type: research
Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis
CONCLUSIONS: These results revealed a new m6A epigenetic method to regulate the progress of atherosclerosis, which suggest approaches for potential therapeutic interventions that target METTL3 for the prevention and treatment of coronary artery diseases.PMID:36230944 | DOI:10.3390/cells11192980
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Yaqing Zhou Rongli Jiang Yali Jiang Yahong Fu Yerbolat Manafhan Jinfu Zhu Enzhi Jia Source Type: research
Vascular Ehlers-Danlos Syndrome: Pathological Variants, Recent Discoveries, and Theoretical Approaches
Vascular Ehlers-Danlos syndrome (vEDS) is a rare autosomal dominant genetic disorder. It is the most fatal among all types of EDS. In addition to typical EDS characteristics, vEDS patients are at risk of blood vessel rupture due to possession of pathogenic variants of the COL3A1 gene, which encodes type III collagen. Type III collagen is a major component of humans’ vascular walls. The management of this disease is possible; however, there is no cure as of present. Recently, discoveries with potential impact on the management of vEDS have been elucidated. Mice with vEDS traits treated with a beta-blocker celiprolol showe...
Source: Cardiology in Review - October 12, 2022 Category: Cardiology Tags: Review Articles Source Type: research
Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology
CONCLUSION: Collectively, we combined network pharmacology and endothelial injury models to investigate the anti-AS mechanism of baicalin. The results demonstrate that baicalin may exert anti-oxidative stress effects by targeting NOX4, providing new mechanisms and insights to baicalin for the treatment of AS.PMID:36192741 | DOI:10.1186/s12906-022-03738-3
Source: Atherosclerosis - October 3, 2022 Category: Cardiology Authors: Mingshuang Li Conglin Ren Source Type: research
miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation
CONCLUSION: Silencing miR-351 upregulates ITGB3 and activates the PIK3R1/Akt pathway, thereby exerting anti-apoptosis and protective effects on endothelial cells.PMID:36180828 | DOI:10.1186/s10020-022-00547-9
Source: Atherosclerosis - September 30, 2022 Category: Cardiology Authors: Hong Li Dan Song Qihui Liu Linlin Li Xiaoshi Sun Jiamei Guo Dianlian Li Ping Li Source Type: research
