Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway

ConclusionsMorphine may prevent I/R-induced myocardial mitochondrial damage by activating EGFR through δ-opioid receptors, in turn increasing RISK and SAFE pathway activity via intracellular ROS. Moreover, morphine may reduce myocardial injury by regulating autophagy but not apoptosis.

http://link.springer.com/10.1007/s10557-021-07215-w

Source: Cardiovascular Drugs and Therapy - September 28, 2022 Category: Cardiology Source Type: research