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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Differential expression of estrogen receptor subtypes in ovarian high-grade serous carcinoma and clear cell carcinoma
CONCLUSIONS: High GPER-1 expression is an independent prognostic factor for PFS in HGSC patients, and GPER-1 may play a role in HGSC cell proliferation.PMID:34646075 | PMC:PMC8499597 | DOI:10.1002/rmb2.12402
Source: Reproductive Biology - October 14, 2021 Category: Reproduction Medicine Authors: Daiken Osaku Tetsuro Oishi Naoshi Kawamura Yuki Iida Hiroaki Komatsu Akiko Kudoh Jun Chikumi Shinya Sato Tasuku Harada Source Type: research

Myostatin increases human trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 Signaling
In this study, we tested the hypothesis that myostatin increases trophoblast cell invasion by upregulating N-cadherin via SMAD2/3-SMAD4 signaling. Primary and immortalized (HTR8/SVneo) trophoblast cells were used as study models. Matrigel-coated transwell invasion assays were used to study the effects of recombinant human myostatin on trophoblast cell invasion. RT-qPCR and Western blot were used to measure myostatin effects on N-cadherin mRNA and protein levels, respectively. Small inhibitor molecules as well as siRNA-mediated knockdown were used to block myostatin receptor and downstream signaling, respectively. Data were...
Source: Biology of Reproduction - January 12, 2022 Category: Reproduction Medicine Authors: Faten AbdelHafez Ahmed Christian Klausen Hua Zhu Peter C K Leung Source Type: research

TGF- β1 inhibits human trophoblast cell invasion by upregulating kisspeptin expression through ERK1/2 but not SMAD signaling pathway
CONCLUSIONS: By illustrating the potential physiological role of TGF-β1 in the regulation of kisspeptin expression, our results may serve to improve current strategies used to treat placental diseases.PMID:35101033 | DOI:10.1186/s12958-022-00902-9
Source: Reproductive Biology - February 1, 2022 Category: Reproduction Medicine Authors: Lanlan Fang Yang Yan Yibo Gao Ze Wu Zhen Wang Sizhu Yang Jung-Chien Cheng Ying-Pu Sun Source Type: research

NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary
CONCLUSIONS: These results indicate that ovarian NDRG1 may play important roles in follicular development, especially in the early luteinization of pre-ovulatory follicles.PMID:35386369 | PMC:PMC8967294 | DOI:10.1002/rmb2.12437
Source: Reproductive Biology - April 7, 2022 Category: Reproduction Medicine Authors: Akemi Nishigaki Hiroaki Tsubokura Mitsuaki Ishida Yoshiko Hashimoto Aya Yoshida Yoji Hisamatsu Tomoko Tsuzuki-Nakao Hiromi Murata Hidetaka Okada Source Type: research

SET improved oocyte maturation by serine/threonine protein phosphatase 2A and inhibited oocyte apoptosis in mouse oocytes
Reprod Biol. 2022 Jun 18;22(3):100668. doi: 10.1016/j.repbio.2022.100668. Online ahead of print.ABSTRACTSET is a multifunctional protein involved in a variety of molecular processes such as cell apoptosis and cell-cycle regulation. In ovaries SET is predominantly expressed in theca cells and oocytes. In polycystic ovary syndrome (PCOS) patients the expression of SET was increased than healthy people. The current study was designed to determine whether SET plays a role in oocyte maturation and apoptosis, which may provide clues for the underlying pathological mechanism of follicular development in PCOS patients. Oocytes at ...
Source: Reproductive Biology - June 21, 2022 Category: Reproduction Medicine Authors: Lingling Gao Siying Wang Jianbo Xu Dan Lu Yugui Cui Source Type: research

Supplementing culture medium with the weak acid, 5,5-dimethyl-2,4-oxazolidinedione (DMO) limits the development  of aneuploid mouse embryos through a Trp53-dependent mechanism
ConclusionThese studies suggest that the development of morphologically normal aneuploid-enriched mouse blastocysts can be inhibited by adding low amounts of DMO to the culture media, which results in elevated levels ofTrp53 mRNA that suppressesOct-4 andCdx2 expression.
Source: Journal of Assisted Reproduction and Genetics - April 14, 2023 Category: Reproduction Medicine Source Type: research

Leukemia inhibitory factor increases the invasiveness of trophoblastic cells through integrated increase in the expression of adhesion molecules and pappalysin 1 with a concomitant decrease in the expression of tissue inhibitor of matrix metalloproteinases
Conclusion(s): Identification of novel molecules associated with a LIF-mediated increase in trophoblastic cell invasion may facilitate our understanding of implantation biology.
Source: Fertility and Sterility - November 5, 2012 Category: Reproduction Medicine Authors: Pankaj Suman, Nachiket Shembekar, Satish Kumar Gupta Tags: Reproductive biology Source Type: research

Regulation of Cyclin D2 Expression and Degradation by Follicle Stimulating Hormone During Rat Granulosa Cell Proliferation In Vitro.
Abstract Cyclin D2 (CCND2, encoded by Ccnd2) plays an important role in the induction of early-to-mid G1 phase transition and is required for granulose cell proliferation during ovarian folliculogenesis. In the present study, we investigated the role of follicle stimulating hormone (FSH) in the regulation of cyclin D2 expression and degradation during rat granulosa cell proliferation in vitro. FSH acutely increased granulosa cell Ccnd2 mRNA abundance and CCND2 protein content as well as proliferation. FSH-induced granulosa cell CCND2 protein content and proliferation were mimicked by forskolin and attenuated by in...
Source: Biology of Reproduction - January 24, 2013 Category: Reproduction Medicine Authors: Han Y, Xia G, Tsang BK Tags: Biol Reprod Source Type: research

The expression and functionality of stromal caveolin 1 in human adenomyosis
This study assessed the functional role of stromal CAV1 and RANTES in a small number of human adenomyosis samples by immunohistochemistry and in primary human ESCs by functional studies. In future investigations, a larger sample size should be adopted and the functional role of stromal CAV1 should be further characterized in animal models. WIDER IMPLICATIONS OF THE FINDINGS Loss of stromal CAV1 expression may play a critical role in the pathogenesis of adenomyosis and is correlated with adenomyosis-related dysmenorrhea. STUDY FUNDING National Basic Research Program of China and Ph.D. Programs Foundation of Ministry of Ed...
Source: Human Reproduction - April 16, 2013 Category: Reproduction Medicine Authors: Zhao, L., Zhou, S., Zou, L., Zhao, X. Tags: Reproductive biology Source Type: research

Bora regulates meiotic spindle assembly and cell cycle during mouse oocyte meiosis
In this study, we examined the expression, localization, and function of Bora during mouse oocyte meiosis. The expression level of Bora was increased during oocyte meiotic maturation, with an elevated level at metaphase. Immunofluorescence analysis showed that Bora was concentrated as a dot shortly after germinal vesicle breakdown (GVBD), associating first with the surrounding chromosomes and then with the spindle throughout the oocyte meiotic maturation. Further experiments confirmed that Bora co‐localized with α‐tubulin at prometaphase/metaphase, but dissociated from α‐tubulin at anaphase/telophase. In metaphase...
Source: Molecular Reproduction and Development - April 23, 2013 Category: Reproduction Medicine Authors: Rui Zhai, Yi‐Feng Yuan, Yi Zhao, Xiao‐Ming Liu, Yan‐Hong Zhen, Fei‐Fei Yang, Li Wang, Cheng‐Zhu Huang, Jing Cao, Li‐Jun Huo Tags: Research Article Source Type: research