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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles ††.
Spatiotemporal expression of aquaporin 9 is critical for the antral growth of mouse ovarian follicles††. Biol Reprod. 2020 Jun 24;: Authors: Lee SE, Kang HK, Ryou C, Cheon YP Abstract Although a few aquaporins (AQPs) expressed in granulosa cells have been postulated to mediate fluid passage into the antrum, the specific expression of AQPs in different follicle cell types and stages and their roles have not been evaluated extensively. The spatiotemporal expression of aquaporin (Aqp) 7, 8, and 9 and the functional roles of Aqp9 in antral growth and ovulation were examined using a superovulation mode...
Source: Biology of Reproduction - June 23, 2020 Category: Reproduction Medicine Authors: Lee SE, Kang HK, Ryou C, Cheon YP Tags: Biol Reprod Source Type: research

ORP9 Knockdown Delays the Maturation of Junction Related Endocytic Structures in the Testis and Leads to Impaired Sperm Release †.
ORP9 Knockdown Delays the Maturation of Junction Related Endocytic Structures in the Testis and Leads to Impaired Sperm Release†. Biol Reprod. 2020 Sep 09;: Authors: Adams A, Vogl W Abstract The release of late spermatids from the seminiferous epithelium requires the internalization of intercellular junctions by Sertoli cell specific structures called 'tubulobulbar complexes' (TBCs). These large, endocytic devices likely evolved from classic clathrin-mediated endocytosis machinery (CME), but have several important morphological differences to CME vesicles. Most notable among these differences is tha...
Source: Biology of Reproduction - September 8, 2020 Category: Reproduction Medicine Authors: Adams A, Vogl W Tags: Biol Reprod Source Type: research

Knockdown of Dnmt1 and Dnmt3a gene expression disrupts preimplantation embryo development through global DNA methylation
ConclusionPrecisely aligned expression of Dnmt genes is highly essential for the fate of an embryo in the early developmental period. Our data indicates that further analysis is mandatory to designate the specific targets of these methylation/demethylation processes in mouse and human preimplantation embryos.
Source: Journal of Assisted Reproduction and Genetics - September 17, 2021 Category: Reproduction Medicine Source Type: research

Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
CONCLUSIONS: Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-[Formula: see text] signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.PMID:37464405 | PMC:PMC10355026 | DOI:10.1186/s12958-023-01116-3
Source: Reproductive Biology - July 18, 2023 Category: Reproduction Medicine Authors: Lydia Baird Ping Cannon Manju Kandel Tuong-Vi Nguyen Anna Nguyen Georgia Wong C íara Murphy Fiona C Brownfoot Elif Kadife Natalie J Hannan Stephen Tong Lucy A Bartho Tu'uhevaha J Kaitu'u-Lino Source Type: research

Oncostatin M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation.
CONCLUSIONS: This study suggests that OSM stimulates the migration and proliferation of EVTs during the first trimester of pregnancy through the down-regulation of E-cadherin. In addition, this study suggests that the effects of OSM on migration and proliferation are related to STAT3 activation, which is important in trophoblast invasiveness. PMID: 24060241 [PubMed - as supplied by publisher]
Source: Reproductive Biology - September 24, 2013 Category: Reproduction Medicine Authors: Ko HS, Choi SK, Kang HK, Kim HS, Jeon JH, Park IY, Shin JC Tags: Reprod Biol Endocrinol Source Type: research

Small RNA regulation of reproductive function
Abstract Post‐transcriptional gene regulation is one mechanism that occurs ‘above the genome’, allowing the cells of an organism to have dramatically different phenotypes and functions. Non‐coding ribonucleic acid (ncRNA) molecules regulate transcript and protein abundance above the level of transcription, and appear to play substantial roles in regulation of reproductive tissues. Three primary classes of small ncRNA are microRNA (miRNA), endogenous small interfering RNA (endo‐siRNA), and PIWI‐interacting RNA (piRNA). These RNA classes have similarities and clear distinctions between their biogenesis and in the...
Source: Molecular Reproduction and Development - October 1, 2013 Category: Reproduction Medicine Authors: Benjamin J. Hale, Cai‐Xia Yang, Jason W. Ross Tags: Review Article Source Type: research

Leptin-Promoted Human Extravillous Trophoblasts Invasion Is MMP14 Dependent and Requires the Crosstalk Between Notch1 and PI3K/Akt Signaling.
Abstract The over-expression of leptin is a crucial feature for the maintenance of pregnancy. The effects of leptin on trophoblasts invasion are important to its reproductive function, but the underlying mechanisms remain poorly understood. MMP14 is a member of matrix metalloproteinase (MMP) family that is closely involved in the invasion process. Here, we characterized the importance of MMP14 in the pro-invasion effect of leptin on EVT cells and elucidated its molecular mechanisms. Transwell assay revealed that leptin promoted invasion of the immortalized EVT cell line HTR-8/SVneo in a dose- and time-related fash...
Source: Biology of Reproduction - February 26, 2014 Category: Reproduction Medicine Authors: Wang H, Cheng H, Shao Q, Dong Z, Xie Q, Zhao L, Wang Q, Kong B, Qu X Tags: Biol Reprod Source Type: research

JunB/Cyclin-D1 imbalance in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise
Conclusions: We described, for the first time, AP-1 expression in PDMSCs derived from physiological and PE placentae. Importantly, we demonstrated that JunB over-expression in PE-PDMSCs affects Cyclin-D1 regulation. Our data suggest a possible contribution of these pathological placental cells to the altered cell cycle regulation typical of preeclamptic placentae.Highlights:
Source: Placenta - April 28, 2014 Category: Reproduction Medicine Authors: A.M. Nuzzo, D. Giuffrida, C. Zenerino, A. Piazzese, E. Olearo, T. Todros, A. Rolfo Tags: Preeclampsia Source Type: research

Expression of Progesterone Receptor Membrane Component-2 Within the Immature Rat Ovary and Its Role in Regulating Mitosis and Apoptosis of Spontaneously Immortalized Granulosa Cells.
Abstract Progesterone receptor membrane component 2 (Pgrmc2) mRNA was detected in the immature rat ovary. By 48 h after eCG, Pgrmc2 mRNA levels decreased by 40% and were maintained at 48 h post hCG. Immunohistochemical studies detected PGRMC2 in oocytes and ovarian surface epithelial, interstitial, thecal, granulosa and luteal cells. PGRMC2 was also present in spontaneously immortalized granulosa cells (SIGCs), localizing to the cytoplasm of interphase cells and apparently to the mitotic spindle of cells in metaphase. Interestingly, PGRMC2 levels appeared to decrease during the G1 stage of the cell cycle. Moreover...
Source: Biology of Reproduction - July 2, 2014 Category: Reproduction Medicine Authors: Griffin D, Liu X, Pru C, Pru JK, Peluso JJ Tags: Biol Reprod Source Type: research

Progesterone Receptor Membrane Component-1 (PGRMC1) and PGRMC-2 Interact to Suppress Entry into the Cell Cycle in Spontaneously Immortalized Rat Granulosa Cells.
Abstract Progesterone receptor membrane component 1 (PGRMC1) and PGRMC2 are expressed in rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs) but their biological roles are not well defined. The present studies demonstrate that depleting either Pgrmc1 or Pgrmc2 in SIGCs increases entry into the cell cycle but does not increase cell proliferation. Rather PGRMC1 and/or PGRMC2-deplete cells accumulate in metaphase and undergo apoptosis. Since both PGRMC1 and PGRMC2 localize to the mitotic spindle, their absence likely accounts for cells arresting in metaphase. Moreover, pull-down assays, co-loca...
Source: Biology of Reproduction - September 24, 2014 Category: Reproduction Medicine Authors: Peluso JJ, Griffin D, Liu X, Horne M Tags: Biol Reprod Source Type: research

Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction
In conclusion, we report that decreased STAT3 expression in placentae may contribute to abnormal trophoblast function in idiopathic FGR-affected pregnancies.
Source: Reproduction - March 30, 2015 Category: Reproduction Medicine Authors: Borg, A. J., Yong, H. E. J., Lappas, M., Degrelle, S. A., Keogh, R. J., Da Silva-Costa, F., Fournier, T., Abumaree, M., Keelan, J. A., Kalionis, B., Murthi, P. Tags: Research Source Type: research

Potential effects of interferon regulatory factor 4 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption.
Abstract Interferon regulatory factor (IRF) 4 has been reported to modulate Toll-like receptor (TLR) signalling. Polyinosinic-polycytidylic acid (poly(I:C)) can be specifically recognised by TLR3, triggering the innate immune response and subsequently resulting in pregnancy loss. In the present study, poly(I:C) was administered to mice with or without TLR3 blockade. Chemokine (C-X-C motif) receptor 4 (CXCR4) expression was measured with or without chemokine (C-X-C motif) ligand 12 (CXCL12) inhibition. In cultured murine splenic mononuclear cells, IRF4 was knocked down by a specific short interference (si) RNA. IRF...
Source: Reproduction, Fertility, and Development - April 15, 2015 Category: Reproduction Medicine Authors: Wang J, Yin T, Wen Y, Tian F, He X, Zhou D, Lin Y, Yang J Tags: Reprod Fertil Dev Source Type: research

Sohlh2 inhibits the apoptosis of mouse primordial follicle oocytes via C-kit/PI3K/Akt/Foxo3a signalling pathway
Publication date: May 2015 Source:Reproductive BioMedicine Online, Volume 30, Issue 5 Author(s): Xiaoli Zhang , Haiyu Zhang , Qing Gao , Shufang Ji , Lujun Bing , Jing Hao We previously reported that bone morphogenetic protein 4/drosophila mothers against decapentaplegic protein (BMP4/Smad) signalling pathway initiated primordial follicle growth and prevented oocyte apoptosis via up-regulation of Sohlh2 and receptor for kit ligand (c-kit). The mechanism underlying this process was not fully elucidated. In the present study, primary oocyte cultures were established from ovaries of 3-day-old female mouse pups by two-step e...
Source: Reproductive BioMedicine Online - May 2, 2015 Category: Reproduction Medicine Source Type: research

Periostin Enhances Migration, Invasion, and Adhesion of Human Endometrial Stromal Cells Through Integrin-Linked Kinase 1/Akt Signaling Pathway
Although our previous study confirmed that periostin (PN) was overexpressed in the eutopic and ectopic endometrial stroma of women with endometriosis by immunohistochemitry, the role of PN in the pathophysiology of endometriosis remains unknown. Thus, we aimed to investigate the effects of PN on endometrial stromal cells (ESCs) migration, invasion, adhesion, and proliferation and to further study the mechanism under this process. Eutopic (EuSCs), ectopic (EcSCs), and normal ESCs (NSCs) were isolated and cultured. We evaluated the above-mentioned biology behaviors and the expression of PN, integrin-linked kinase 1 (ILK1), a...
Source: Reproductive Sciences - August 10, 2015 Category: Reproduction Medicine Authors: Xu, X., Zheng, Q., Zhang, Z., Zhang, X., Liu, R., Liu, P. Tags: Original Articles Source Type: research