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Specialty: Reproduction Medicine

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Total 316 results found since Jan 2013.

The Interleukin-6 trans-signaling promotes progesterone production in human granulosa-lutein cells
Biol Reprod. 2022 Jan 29:ioac020. doi: 10.1093/biolre/ioac020. Online ahead of print.ABSTRACTAs a critical paracrine regulator of multiple reproductive functions, the cytokine interleukin-6 (IL-6) is expressed in human granulosa cells and can be detected in follicular fluid. At present, the functional role of IL-6 in the regulation of ovarian steroidogenesis is controversial. Moreover, the detailed molecular mechanisms by which IL-6 regulates the production of progesterone in human granulosa cells remain to be elucidated. In the present study, we used primary and immortalized human granulosa-lutein (hGL) cells to investiga...
Source: Reproductive Biology - January 31, 2022 Category: Reproduction Medicine Authors: Sai-Jiao Li Hsun-Ming Chang Jeremy H Wang Jing Yang Peter C K Leung Source Type: research

Protective role of Cytoglobin and Neuroglobin against the Lipopolysaccharide (LPS)-induced inflammation in Leydig cells ex vivo
Reprod Biol. 2022 Feb 1;22(1):100595. doi: 10.1016/j.repbio.2021.100595. Online ahead of print.ABSTRACTLeydig cells are responsible for testosterone production in male testis upon stimulation by luteinizing hormone. Inflammation and oxidative stress related Leydig cell dysfunction is one of the major causes of male infertility. Cytoglobin (CYGB) and Neuroglobin (NGB) are two globin family member proteins which protect cells against oxidative stress. In the current study, we established a Lipopolysaccharide (LPS)-induced inflammation model in TM3 Leydig cell culture to study the function of CYGB and NGB proteins under infla...
Source: Reproductive Biology - February 5, 2022 Category: Reproduction Medicine Authors: Derya Sa ğraç Selinay Şenkal Taha Bartu Hayal Selami Demirci Hatice Burcu Şişli Ayla Bur çin Asutay Ay şegül Doğan Source Type: research

Growth differentiation factor-11 downregulates steroidogenic acute regulatory protein expression through ALK5-mediated SMAD3 signaling pathway in human granulosa-lutein cells
CONCLUSIONS: This study increases the understanding of the biological function of GDF-11 and provides important insights into the regulation of ovarian steroidogenesis.PMID:35183204 | DOI:10.1186/s12958-022-00912-7
Source: Reproductive Biology - February 20, 2022 Category: Reproduction Medicine Authors: Qiongqiong Jia Boqun Liu Xuan Dang Yanjie Guo Xiaoyu Han Tinglin Song Jung-Chien Cheng Lanlan Fang Source Type: research

Aquaporin 9 regulates Leydig cell steroidogenesis in diabetes
Syst Biol Reprod Med. 2022 Mar 30:1-14. doi: 10.1080/19396368.2022.2033350. Online ahead of print.ABSTRACTDiabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play a pivotal role in male reproductive function. In the current study, we investigated the relationship between AQPs and testicular steroidogenesis under hyperglycemia in vivo and in vitro. The effect of high glucose on the role of AQPs in Leydi...
Source: Systems Biology in Reproductive Medicine - March 30, 2022 Category: Reproduction Medicine Authors: Arun Kannan Lezy Flora Mariajoseph-Antony Antojenifer Panneerselvam Chithra Loganathan Diwakar Kiduva Jothiraman Kumarasamy Anbarasu Chidambaram Prahalathan Source Type: research

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells
CONCLUSIONS: Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells.PMID:35395768 | DOI:10.1186/s12958-022-00937-y
Source: Reproductive Biology - April 9, 2022 Category: Reproduction Medicine Authors: Hsun-Ming Chang Long Bai Yi-Min Zhu Peter C K Leung Source Type: research

Activin a promotes hyaluronan production and upregulates versican expression in human granulosa cells via the ALK4-SMAD2/3-SMAD4 signaling pathway
Biol Reprod. 2022 Apr 9:ioac070. doi: 10.1093/biolre/ioac070. Online ahead of print.ABSTRACTHyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 (HAS2) is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and is critical for successful ovulation. Activin A is a critical intrafollicular regulator of ovarian function. Although activin A has been shown to promote cumulus matrix expansion in mice, the functional role of activin A in the regulation of cumulus expansion in the human ovary remains to be elucidated....
Source: Biology of Reproduction - April 11, 2022 Category: Reproduction Medicine Authors: Shen Tian Han Zhang Hsun-Ming Chang Christian Klausen He-Feng Huang Min Jin Peter C K Leung Source Type: research

Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells
CONCLUSIONS: Our findings provide new insight into the molecular mechanism by which BMP2 promotes the production of hyaluronan in human granulosa cells.PMID:35395768 | PMC:PMC8991488 | DOI:10.1186/s12958-022-00937-y
Source: Reproductive Biology - April 9, 2022 Category: Reproduction Medicine Authors: Hsun-Ming Chang Long Bai Yi-Min Zhu Peter C K Leung Source Type: research

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