Filtered By:
Specialty: Reproduction Medicine

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 316 results found since Jan 2013.

RKIP is decreased in laboring myometrium and modulates inflammation-induced pro-labor mediators
In conclusion, in human primary myometrial cells, RKIP negatively regulates IL1B- and TNF-induced expression and or secretion of pro-inflammatory and pro-labor mediators by inhibiting NF-B RELA activation.
Source: Reproduction - March 8, 2017 Category: Reproduction Medicine Authors: Lappas, M. Tags: Research Source Type: research

ITGAV (alpha v integrins) bind SPP1 (osteopontin) to support trophoblast cell adhesion
This study determined whether alpha v (av) integrins (ITGAV) directly mediate porcine trophoblast cell adhesion to secreted phosphoprotein 1 (SPP1, also known as osteopontin (OPN)) and examined the temporal/spatial expression of ITGAV, beta 3 (b3, ITGB3) and beta 6 (b6, ITGB6) integrin subunits, and SPP1, at the uterine–placental interface of pigs. Knockdown of ITGAV in porcine Tr (pTr2) cells by siRNA reduced pTr2 attachment to SPP1. In situ hybridization confirmed the presence of ITGAV, ITGB3 and ITGB6 mRNAs in uterine LE and conceptus Tr between Days 9 and 60 of gestation, with no change in the magnitude of expres...
Source: Reproduction - April 6, 2017 Category: Reproduction Medicine Authors: Frank, J. W., Seo, H., Burghardt, R. C., Bayless, K. J., Johnson, G. A. Tags: Research Source Type: research

Hypoxia-inducible factor-1{alpha} promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis
Endometriosis is a benign gynecological disease that shares some characteristics with malignancy like migration and invasion. It has been reported that both hypoxia-inducible factor-1α (HIF-1α) and autophagy were upregulated in ectopic endometrium of patients with ovarian endometriosis. However, the crosstalk between HIF-1α and autophagy in the pathogenesis of endometriosis remains to be clarified. Accordingly, we investigated whether autophagy was regulated by HIF-1α, as well as whether the effect of HIF-1α on cell migration and invasion is mediated through autophagy upregulation. Here, we fo...
Source: Reproduction - April 25, 2017 Category: Reproduction Medicine Authors: Liu, H., Zhang, Z., Xiong, W., Zhang, L., Xiong, Y., Li, N., He, H., Du, Y., Liu, Y. Tags: Research Source Type: research

miR ‐182 selectively targets HOXA10 in goat endometrial epithelium cells in vitro
In conclusion, miR‐182 targeted HOXA10 selectively in EECs in vitro, and HOXA10 played an important role in maintaining the function of EECs in dairy goats.
Source: Reproduction in Domestic Animals - July 30, 2017 Category: Reproduction Medicine Authors: L Zhang, X ‐R Liu, J‐Z Liu, Y‐X Song, Z‐Q Zhou, B‐Y Cao Tags: ORIGINAL ARTICLE Source Type: research

NLRP7 contributes to in vitro decidualization of endometrial stromal cells.
CONCLUSIONS: NLRP7 was upregulated and translocated to the nucleus of the endometrial stromal cells in an in vitro decidualization model. Overexpressed NLRP7 promoted the IGFBP-1 expression and PR reporter activation. IGFBP-1 expression decreased with the knockdown of NLRP7. Therefore, we suggest that NLRP7 contributes to in vitro decidualization of endometrial stromal cells. PMID: 28810880 [PubMed - in process]
Source: Reproductive Biology - August 15, 2017 Category: Reproduction Medicine Authors: Huang JY, Yu PH, Li YC, Kuo PL Tags: Reprod Biol Endocrinol Source Type: research

Mouse double minute homologue 2 (MDM2) downregulation by miR-661 impairs human endometrial epithelial cell adhesive capacity.
This study highlights a potential new mechanism by which human blastocyst-secreted miR-661 reduces endometrial epithelial cell adhesion; via downregulation of MDM2. These findings suggest that MDM2 contributes to endometrial-blastocyst adhesion, implantation and infertility in women. PMID: 28847363 [PubMed - as supplied by publisher]
Source: Reproduction, Fertility, and Development - August 29, 2017 Category: Reproduction Medicine Authors: Winship A, Ton A, Van Sinderen M, Menkhorst E, Rainczuk K, Griffiths M, Cuman C, Dimitriadis E Tags: Reprod Fertil Dev Source Type: research

The IL-1 β signalling pathway and its role in regulating pro-inflammatory and pro-labour mediators in human primary myometrial cells.
This study sought to determine the role of the adaptor proteins myeloid differentiation primary response 88 (MyD88), tumour necrosis factor receptor-associated factor 6 (TRAF6), IL-1 receptor-associated kinase 4 (IRAK4) and transforming growth factor beta-activated kinase 1 (TAK1) in IL-1β-induced formation of pro-inflammatory and pro-labour mediators in human myometrium. Human primary myometrial cells were transfected with siRNA against MyD88 (siMYD88), TRAF6 (siTRAF6), IRAK4 (siIRAK4) or TAK1 (siTAK1), treated with IL-1β, and assayed for the mRNA expression and or secretion of pro-inflammatory and pro-labour mediators....
Source: Reproductive Biology - October 6, 2017 Category: Reproduction Medicine Authors: Lappas M Tags: Reprod Biol Source Type: research

Iron suppresses ovarian granulosa cell proliferation and arrests cell cycle through regulating p38 MAPK/p53/p21 pathway.
Abstract Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferatio...
Source: Biology of Reproduction - August 28, 2017 Category: Reproduction Medicine Authors: Chen MJ, Chou CH, Shun CT, Mao TL, Wen WF, Chen CD, Chen SU, Yang YS, Ho HN Tags: Biol Reprod Source Type: research

Calcitriol regulates immune genes CD14 and CD180 to modulate LPS responses in human trophoblasts
We assessed the response of primary cultures of placental villous mononucleated trophoblasts and multinucleated syncytiotrophoblast to calcitriol, the most biologically active form of vitamin D. Whole-genome microarray data showed that calcitriol modulates the expression of many genes in trophoblasts within 6 hours of exposure and RT-qPCR revealed similar responses in cytotrophoblasts, syncytiotrophoblasts and villous explants. Both cytotrophoblasts and syncytiotrophoblasts expressed genes for the vitamin D receptor, for LRP2 and CUBN that mediate internalization of calcidiol, for CYP27B1 that encodes the enzyme that conve...
Source: Reproduction - October 31, 2017 Category: Reproduction Medicine Authors: Longtine, M. S., Cvitic, S., Colvin, B. N., Chen, B., Desoye, G., Nelson, D. M. Tags: Research Source Type: research

Differential effects of follistatin on porcine oocyte competence and cumulus cell gene expression in vitro
This study investigated the paracrine and autocrine activity of follistatin (FS), which is secreted by oocytes and cumulus cells as part of porcine embryogenesis. Immunohistochemical (IHC) localization of follistatin was conducted on 100 randomly selected early‐ and late‐cleaving two‐cell embryos. Dissociated cumulus cells were treated with various doses of follistatin for determination of the follistatin gene (FST) mRNA expression levels by quantitative real‐time PCR analysis. Microinjection of siRNA induced a downregulation of FST mRNA during embryonic development, thereby decreasing the proportion embryos develo...
Source: Reproduction in Domestic Animals - November 14, 2017 Category: Reproduction Medicine Authors: Z Guo, MS Islam, D Liu, G Liu, L Lv, Y Yang, B Fu, L Wang, Z Liu, H He, H Wu Tags: ORIGINAL ARTICLE Source Type: research

De novo transcription of thyroid hormone receptors is essential for early bovine embryo development in vitro.
In conclusion, THRs are transcribed soon after fertilisation, before major activation of the embryonic genome, and they are essential for bovine embryo development in vitro. PMID: 29179810 [PubMed - as supplied by publisher]
Source: Reproduction, Fertility, and Development - November 28, 2017 Category: Reproduction Medicine Authors: Rho NY, Ashkar FA, Revay T, Madan P, Rho GJ, King WA, Favetta LA Tags: Reprod Fertil Dev Source Type: research

Human Endometrial Stromal Cell Decidualization Requires Transcriptional Reprogramming by PLZF.
Abstract Infertility and early embryo-miscarriage is linked to inadequate endometrial decidualization. Although transcriptional reprogramming is known to drive decidualization in response to progesterone, the key signaling effectors that directly mediate this hormone response are not fully known. This knowledge-gap is clinically significant because identifying the early signals that directly mediate progesterone-driven decidualization will address some of the current limitations in diagnosing and therapeutically treating patients at most risk for early pregnancy loss. We recently revealed that the promyelocytic le...
Source: Biology of Reproduction - November 25, 2017 Category: Reproduction Medicine Authors: Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP Tags: Biol Reprod Source Type: research

PARK7 regulates inflammation-induced pro-labour mediators in myometrial and amnion cells
Preterm birth is a prevalent cause of neonatal deaths worldwide. Inflammation has been implicated in spontaneous preterm birth involved in the processes of uterine contractility and membrane rupture. Parkinson protein 7 (PARK7) has been found to play an inflammatory role in non-gestational tissues. The aims of this study were to determine the expression of PARK7 in myometrium and fetal membranes with respect to term labour onset and to elucidate the effect of PARK7 silencing in primary myometrium and amnion cells on pro-inflammatory and pro-labour mediators. PARK7 mRNA expression was higher in term myometrium and fetal mem...
Source: Reproduction - January 22, 2018 Category: Reproduction Medicine Authors: Lim, R., Barker, G., Lappas, M. Tags: Research Source Type: research

Porcine Parvovirus infection impairs progesterone production in Luteal Cells through MAPKs, p53 and mitochondria-mediated Apoptosis.
Abstract Porcine parvovirus (PPV) is a major virus leading to fetal death in swine. However, the effects of PPV infection on sows are poorly understood. The aim of this study was to investigate the effects of PPV on porcine steroidogenic luteal cells (SLCs) survival and functions and underlying mechanisms. In vivo experiment results showed artificial infection of PPV significantly reduced the concentration of serum progesterone and induced histopathological lesions and SLCs apoptosis in porcine corpora luteum. In vitro cultured primary porcine SLCs, PPV could infect and replicate in SLCs and induced SLCs apoptosis...
Source: Biology of Reproduction - January 18, 2018 Category: Reproduction Medicine Authors: Zhang L, Wang Z, Zhang J, Luo X, Du Q, Chang L, Zhao X, Huang Y, Tong D Tags: Biol Reprod Source Type: research

miR-210 and GPD1L regulate EDN2 in primary and immortalized human granulosa-lutein cells
This study highlights the novel regulatory roles of miR-210 and its gene target, GPD1L, in hypoxia and cAMP-induced EDN2 by human granulosa-lutein cells.
Source: Reproduction - January 30, 2018 Category: Reproduction Medicine Authors: Shrestha, K., Onasanya, A. E., Eisenberg, I., Wigoda, N., Yagel, S., Yalu, R., Meidan, R., Imbar, T. Tags: Research Source Type: research