Oncostatin M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation.

CONCLUSIONS: This study suggests that OSM stimulates the migration and proliferation of EVTs during the first trimester of pregnancy through the down-regulation of E-cadherin. In addition, this study suggests that the effects of OSM on migration and proliferation are related to STAT3 activation, which is important in trophoblast invasiveness.
PMID: 24060241 [PubMed - as supplied by publisher]

Source: Reproductive Biology - September 24, 2013 Category: Reproduction Medicine Authors: Ko HS, Choi SK, Kang HK, Kim HS, Jeon JH, Park IY, Shin JC Tags: Reprod Biol Endocrinol Source Type: research