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Total 1545 results found since Jan 2013.
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1 α pathway
Free Radic Res. 2023 Jan 2:1-15. doi: 10.1080/10715762.2022.2163244. Online ahead of print.ABSTRACTSevere acute pancreatitis (SAP) is an inflammatory disorder of the exocrine pancreas associated with high morbidity and mortality. SAP has been proven to trigger mitochondria dysfunction in the pancreas. We found that Deoxyarbutin (dA) recovered impaired mitochondrial function. High-temperature requirement protein A2 (HtrA2), a mitochondrial serine protease upstream of PGC-1α, is charge of quality control in mitochondrial homeostasis. The molecular docking study indicated that there was a potential interaction between dA and...
Source: Free Radical Research - January 2, 2023 Category: Research Authors: Yangying Li Yuda Zhu Shiyi Li Yuman Dong Chengyu Wan Xiuxian Yu Guang Xin Zeliang Wei Fan Li Yilan Wang Kun Zhang Qingqiu Chen Cuicui Zhang E Wen Hai Niu Wen Huang Source Type: research
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro
ConclusionsTaken together, this study provides evidence that the protective effect of ANXA1 (Ac2-26) on SI-AKI largely depends on the negative regulation of inflammation and apoptosis via the Fpr2 receptor.
Source: Inflammation Research - December 22, 2022 Category: Research Source Type: research
Targeting regulation of VEGF by BPTF in non-small cell lung cancer and its potential clinical significance
ConclusionsBPTF positively regulates VEGF expression and its high expression predicts a better efficacy of bevacizumab treatment in NSCLC.
Source: European Journal of Medical Research - December 19, 2022 Category: Research Source Type: research
Bim downregulation by activation of NF- κB p65, Akt, and ERK1/2 is associated with adriamycin and dexamethasone resistance in multiple myeloma cells
In this study, we examined the MDR mechanism in adriamycin- and dexamethasone-resistant cells. RPMI8226/ADM, ARH-77/ADM, RPMI8226/DEX, and ARH-77/DEX cells exhibited enhanced nuclear factor κB (NF-κB) p65, Akt, and extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Combination treatment with NF-κB p65, phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinase 1/2 (MEK1/2) inhibitors resensitized to adriamycin and dexamethasone via increased Bim expression. A lthough treatment with MDR1 or Survivin siRNA did not overcome adriamycin and dexamethasone resistance in RPMI8226/ADM and RPMI8226/DEX cel...
Source: Clinical and Experimental Medicine - November 30, 2022 Category: Research Source Type: research
STAT3 signaling mediates peritoneal fibrosis by activating hyperglycolysis
CONCLUSIONS: si-STAT3 attenuated the HG-induced EMT and hyperglycolysis, and the overexpression of STAT3 could induce EMT in HMrSV5 cells. 3PO could markedly attenuate HG-induced EMT by decreasing PFKEB3 in HMrSV5 cells. In addition, we demonstrated that inhibiting STAT3 signaling or peritoneal hyperglycolysis could attenuate peritoneal fibrosis and angiogenesis in vivo. Our findings linked the STAT3/PFKFB3 signaling to the development of PF. HG/STAT3/PFKFB3 might promote the progression of PF through regulating profibrosis and angiogenesis.PMID:36398234 | PMC:PMC9641446
Source: American Journal of Translational Research - November 18, 2022 Category: Research Authors: Jiao Fu Nan Li Mengmeng He Dake Huang Pei Zhang Source Type: research
