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Total 1545 results found since Jan 2013.
Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
CONCLUSION: We propose that DNA demethylation followed by increased expression of key genes may be one of the factors responsible for the progression and maintenance of the resistant cell phenotype that includes exosome-induced resistance.PMID:37645026 | PMC:PMC10460766 | DOI:10.34172/bi.2023.27490
Source: BioImpacts - August 30, 2023 Category: Research Authors: Yuri Yu Shchegolev Danila V Sorokin Alexander M Scherbakov Olga E Andreeva Diana I Salnikova Ekaterina I Mikhaevich Margarita V Gudkova Mikhail A Krasil'nikov Source Type: research
Extracellular Vesicles and Ischemic Cardiovascular Diseases
Adv Exp Med Biol. 2023;1418:57-68. doi: 10.1007/978-981-99-1443-2_4.ABSTRACTCharacterized by coronary artery obstruction or stenosis, ischemic cardiovascular diseases as advanced stages of coronary heart diseases commonly lead to left ventricular aneurysm, ventricular septal defect, and mitral insufficiency. Extracellular vesicles (EVs) secreted by diverse cells in the body exert roles in cell-cell interactions and intrinsic cellular regulations. With a lipid double-layer membrane and biological components such as DNA, protein, mRNA, microRNAs (miRNA), and siRNA inside, the EVs function as paracrine signaling for the patho...
Source: Advances in Experimental Medicine and Biology - August 21, 2023 Category: Research Authors: Yujiao Zhu Siqi Wang Xuerui Chen Source Type: research
Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes
CONCLUSION: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets.PMID:37560235 | PMC:PMC10408544
Source: American Journal of Translational Research - August 10, 2023 Category: Research Authors: Ting Xie Xunshan Ren Huangming Zhuang Fuze Jiang Yuelong Zhang Panghu Zhou Source Type: research
