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Total 1545 results found since Jan 2013.
Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes
CONCLUSION: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets.PMID:37560235 | PMC:PMC10408544
Source: American Journal of Translational Research - August 10, 2023 Category: Research Authors: Ting Xie Xunshan Ren Huangming Zhuang Fuze Jiang Yuelong Zhang Panghu Zhou Source Type: research
Stable expression of shRNA for the control of recombinant adenovirus replication
Braz J Med Biol Res. 2023 Jul 21;56:e12682. doi: 10.1590/1414-431X2023e12682. eCollection 2023.ABSTRACTPreventing the replication of adenovirus could have practical uses, such as controlling infection with wild-type virus or in applications involving recombinant vectors. Mainly transient methods have been used to inhibit adenovirus replication, including siRNA or drugs. Here, we tested whether stable expression of shRNA designed to target hexon, Iva2, or pol can inhibit the replication of a recombinant adenoviral vector, Ad-LacZ (serotype 5, E1/E3 deleted), in 293T cells. Significant knockdown correlating with reduced Ad-L...
Source: Brazilian Journal of Medical and Biological Research - July 26, 2023 Category: Research Authors: M V G Lana F Antunes N G Tessarollo B E Strauss Source Type: research
