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Total 1545 results found since Jan 2013.

Stable expression of shRNA for the control of recombinant adenovirus replication
Braz J Med Biol Res. 2023 Jul 21;56:e12682. doi: 10.1590/1414-431X2023e12682. eCollection 2023.ABSTRACTPreventing the replication of adenovirus could have practical uses, such as controlling infection with wild-type virus or in applications involving recombinant vectors. Mainly transient methods have been used to inhibit adenovirus replication, including siRNA or drugs. Here, we tested whether stable expression of shRNA designed to target hexon, Iva2, or pol can inhibit the replication of a recombinant adenoviral vector, Ad-LacZ (serotype 5, E1/E3 deleted), in 293T cells. Significant knockdown correlating with reduced Ad-L...
Source: Brazilian Journal of Medical and Biological Research - July 26, 2023 Category: Research Authors: M V G Lana F Antunes N G Tessarollo B E Strauss Source Type: research

Glycyrrhizic Acid Protects Glomerular Podocytes Induced by High Glucose by Modulating SNARK/AMPK Signaling Pathway
ConclusionGA can protect podocytes and alleviate fibrosis and inflammation induced by high glucose, which is related to the AMPK signaling pathway. Meanwhile, knockdown of SNARK protein can inhibit the AMPK signaling pathway, aggravate fibrosis, and increase inflammation.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 14, 2023 Category: Research Source Type: research

Stat5a promotes < em > Col10a1 < /em > gene expression during chondrocyte hypertrophic differentiation
CONCLUSIONS: Our results support that Stat5a promoted Col10a1 expression and chondrocyte hypertrophic differentiation, possibly via interaction with the 150-bp Col10a1 cis-enhancer.PMID:37434818 | PMC:PMC10331691
Source: American Journal of Translational Research - July 12, 2023 Category: Research Authors: Xuan Wu Chen Chen Tiaotiao Han Huiqin Bian Jinnan Chen Ruoxuan Hei Ye Meng Chenjing Wu Yaojuan Lu Junxia Gu Longwei Qiao Qiping Zheng Source Type: research