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Total 1545 results found since Jan 2013.
Stat5a promotes < em > Col10a1 < /em > gene expression during chondrocyte hypertrophic differentiation
CONCLUSIONS: Our results support that Stat5a promoted Col10a1 expression and chondrocyte hypertrophic differentiation, possibly via interaction with the 150-bp Col10a1 cis-enhancer.PMID:37434818 | PMC:PMC10331691
Source: American Journal of Translational Research - July 12, 2023 Category: Research Authors: Xuan Wu Chen Chen Tiaotiao Han Huiqin Bian Jinnan Chen Ruoxuan Hei Ye Meng Chenjing Wu Yaojuan Lu Junxia Gu Longwei Qiao Qiping Zheng Source Type: research
USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis
ConclusionsOverall, USP10 was shown to regulate inflammatory responses by stabilizing the NEMO protein, which may be a potential therapeutic target for sepsis-induced lung injury.
Source: Inflammation Research - July 12, 2023 Category: Research Source Type: research
High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany
CONCLUSION: In this real-world patient population referred to German lipid clinics for elevated LDL-C levels, inclisiran demonstrated a high interindividual variability in LDL-C reductions. Further research is warranted to elucidate reasons for the interindividual variability in drug efficacy.PMID:37422840 | DOI:10.1007/s00392-023-02247-8
Source: Clin Med Res - July 9, 2023 Category: Research Authors: U Makhmudova U Schatz N Perakakis U Kassner F Schumann C Axthelm P St ürzebecher D L Sinning A Doevelaar B Rohn T Westhoff A Vogt M Scholl U K ästner J-A Geiling K Stach J Mensch E Lorenz C Paitazoglou I Eitel A Baessler E Steinhagen-Thiessen W Koenig P Source Type: research
