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Total 1545 results found since Jan 2013.
ETS-1/c-Met drives resistance to sorafenib in hepatocellular carcinoma
CONCLUSION: c-Met overexpression and activation is an essential mechanism of sorafenib resistance in HCC. Combination therapy of sorafenib plus c-Met inhibitor overcame the resistance of sorafenib-targeted therapy for HCC.PMID:36915773 | PMC:PMC10006745
Source: American Journal of Translational Research - March 14, 2023 Category: Research Authors: Yongfang Ma Xueke Liu Xiaolong Tang Source Type: research
FERMT1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLRP3/NF- κB pathway
Exp Anim. 2023 Feb 3. doi: 10.1538/expanim.22-0145. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is an incurable neurological disease. Microglia activation and its related inflammation contribute to ICH-associated brain damage. FERM domain containing kindlin 1 (FERMT1) is an integrin-binding protein that participates in microglia-associated inflammation, but its role in ICH is unclear. An ICH model was constructed by injecting 50 μl of autologous blood into the bregma of rats. FERMT1 siRNA was injected into the right ventricle of the rat for knockdown of FERMT1. A significant striatal hematoma was observed...
Source: Experimental Animals - February 5, 2023 Category: Research Authors: Jianqiang Wei Jing Yin Ying Cui Kaijie Wang Mingyan Hong Jianzhong Cui Source Type: research
Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrin β3/FAK/Akt Pathway
ConclusionThese findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrin β3/FAK/Akt pathway.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 21, 2023 Category: Research Source Type: research
siRNA-E6 sensitizes HPV-16-related cervical cancer through Oxaliplatin: an in vitro study on anti-cancer combination therapy
ConclusionInhibition of E6 oncogene expression and subsequent E6-siRNA with Oxaliplatin combination therapy could be a novel strategy for cervical cancer treatment.Graphical Abstract
Source: European Journal of Medical Research - January 21, 2023 Category: Research Source Type: research
Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet
ConclusionInhibiting ERS in ECs could improve the function of AVGs.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 14, 2023 Category: Research Source Type: research
Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1 α pathway
Free Radic Res. 2023 Jan 2:1-15. doi: 10.1080/10715762.2022.2163244. Online ahead of print.ABSTRACTSevere acute pancreatitis (SAP) is an inflammatory disorder of the exocrine pancreas associated with high morbidity and mortality. SAP has been proven to trigger mitochondria dysfunction in the pancreas. We found that Deoxyarbutin (dA) recovered impaired mitochondrial function. High-temperature requirement protein A2 (HtrA2), a mitochondrial serine protease upstream of PGC-1α, is charge of quality control in mitochondrial homeostasis. The molecular docking study indicated that there was a potential interaction between dA and...
Source: Free Radical Research - January 2, 2023 Category: Research Authors: Yangying Li Yuda Zhu Shiyi Li Yuman Dong Chengyu Wan Xiuxian Yu Guang Xin Zeliang Wei Fan Li Yilan Wang Kun Zhang Qingqiu Chen Cuicui Zhang E Wen Hai Niu Wen Huang Source Type: research
