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Total 1545 results found since Jan 2013.

High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany
CONCLUSION: In this real-world patient population referred to German lipid clinics for elevated LDL-C levels, inclisiran demonstrated a high interindividual variability in LDL-C reductions. Further research is warranted to elucidate reasons for the interindividual variability in drug efficacy.PMID:37422840 | DOI:10.1007/s00392-023-02247-8
Source: Clin Med Res - July 9, 2023 Category: Research Authors: U Makhmudova U Schatz N Perakakis U Kassner F Schumann C Axthelm P St ürzebecher D L Sinning A Doevelaar B Rohn T Westhoff A Vogt M Scholl U K ästner J-A Geiling K Stach J Mensch E Lorenz C Paitazoglou I Eitel A Baessler E Steinhagen-Thiessen W Koenig P Source Type: research

Characterization of RACK1-depleted mammalian cells by a palette of microscopy approaches reveals defects in cell cycle progression and polarity establishment
Exp Cell Res. 2023 Jun 30:113695. doi: 10.1016/j.yexcr.2023.113695. Online ahead of print.ABSTRACTThe Receptor for Activated C Kinase 1 (RACK1) is an evolutionarily conserved scaffold protein involved in the regulation of numerous cellular processes. Here, we used CRISPR/Cas9 and siRNA to reduce the expression of RACK1 in Madin-Darby Canine Kidney (MDCK) epithelial cells and Rat2 fibroblasts, respectively. RACK1-depleted cells were examined using coherence-controlled holographic microscopy, immunofluorescence, and electron microscopy. RACK1 depletion resulted in decreased cell proliferation, increased cell area and perimet...
Source: Biomed Res - July 2, 2023 Category: Research Authors: Vera Chvalova Vignesh Venkadasubramanian Zuzana Klimova Jana Vojtova Oldrich Benada Ondrej Vanatko Tomas Vomastek Tomas Grousl Source Type: research

Liraglutide ameliorates hepatic steatosis via retinoic acid receptor ‐related orphan receptor α‐mediated autophagy pathway
AbstractLiraglutide, an analog of human glucagon-like peptide-1 (GLP-1), has been found to improve hepatic steatosis in clinical practice. However, the underlying mechanism remains to be fully defined. Increasing evidence suggests that retinoic acid receptor-related orphan receptor α (RORα) is involved in hepatic lipid accumulation. In the current study, we investigated whether the ameliorating impact of liraglutide on lipid-induced hepatic steatosis is dependent on RORα activity and examined the underlying mechanisms. Cre-loxP-mediated, liver-specificRor α knockout (Rora LKO) mice, and littermate controls with aRoralo...
Source: IUBMB Life - June 14, 2023 Category: Research Authors: Xiaoqian Yu, Xiaoqi Bian, Hongmei Zhang, Shanshan Yang, Daxin Cui, Zhiguang Su Tags: RESEARCH ARTICLE Source Type: research

Mechanisms of MALAT1 regulating proliferative diabetic retinopathy via targeting miR-126-5p
CONCLUSIONS: MALAT1 promotes PDR by inhibiting miR126-5p and inducing REC proliferation, migration and angiogenesis.PMID:37303661 | PMC:PMC10251023
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Wei Zhao Yanli Liu Cairui Li Zhijian Yin Yi Liu Meixia An Source Type: research