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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research

Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells
CONCLUSIONS: C3 was elevated in RPE under environmental stimulus and long-term exposure to specified concentration of C3a increased CCN2/CTGF expression in RPE, which could be partially reversed by C3 siRNA.PMID:36276919 | PMC:PMC9581697 | DOI:10.1155/2022/3259453
Source: Journal of Ophthalmology - October 24, 2022 Category: Opthalmology Authors: Kang Xiao Zhiyan Xu Zhengyu Chen Qin Long Youxin Chen Source Type: research

Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Experimental Eye Research - November 26, 2022 Category: Opthalmology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research

Heparanase-mediated histone 3 acetylation regulates VEGF gene transcription in the hyperglycemia and hypoxia human retinal endothelial cells
Exp Eye Res. 2023 Jun 3:109519. doi: 10.1016/j.exer.2023.109519. Online ahead of print.ABSTRACTHeparanase (HPA) is believed that might mediate histone 3 lysine 9 acetylation (H3K9ac) to regulate vascular endothelial growth factor (VEGF) gene expressions in the hyperglycemia and hypoxia human retinal endothelial cells (HRECs). Cultured human retinal endothelial cells (HRECs) in hyperglycemia, hypoxia, siRNA, and normal medium, respectively. Distributions of H3K9ac and HPA in HRECs were analyzed by immunofluorescence. Western blot and real-time PCR were respectively used to evaluate the expression of HPA, H3K9ac, and VEGF. T...
Source: Experimental Eye Research - June 5, 2023 Category: Opthalmology Authors: Xuan Leng Jingwei Wang Xin Song Jie Hu Lin Lu Source Type: research

Rapamycin Enhances TNF-α-Induced Secretion of IL-6 and IL-8 through Suppressing PDCD4 Degradation in Orbital Fibroblasts.
Conclusion: Rapamycin enhances the TNF-α-induced secretion of IL-6 and IL-8 by suppressing PDCD4 degradation in orbital fibroblasts. PMID: 23281820 [PubMed - as supplied by publisher]
Source: Current Eye Research - January 2, 2013 Category: Opthalmology Authors: Lee WM, Paik JS, Cho WK, Oh EH, Lee SB, Yang SW Tags: Curr Eye Res Source Type: research

Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91.
Abstract Recent research using a rat oxygen-induced retinopathy model has demonstrated that the G protein-coupled receptor 91 (GPR91) of retinal ganglion neurons is the principal respondent to succinate and consequently induces the release of angiogenic factor vascular endothelial growth factor (VEGF). The aim of this study was to determine whether GPR91 modulate the release of VEGF from retinal ganglion cells in a high-glucose model in vitro and to dissect the role of GPR91 in the pathogenesis of diabetic retinopathy. We constructed a lentiviral small hairpin RNA (shRNA) expression vector targeting GPR91 (LV.shGP...
Source: Experimental Eye Research - February 1, 2013 Category: Opthalmology Authors: Hu J, Wu Q, Li T, Chen Y, Wang S Tags: Exp Eye Res Source Type: research

High Glucose-Induced Downregulation of Connexin 30.2 Promotes Retinal Vascular Lesions: Implications for Diabetic Retinopathy Retinal Cell Biology
Conclusions. These results indicate that HG- or diabetes-induced downregulation of Cx30.2 expression and decrease in GJIC activity play a critical role in the development of retinal vascular lesions in early DR.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Manasson, J., Tien, T., Moore, C., Kumar, N. M., Roy, S. Tags: Retinal Cell Biology Source Type: research

A Key Role for ROCK in TNF-{alpha}-Mediated Diabetic Microvascular Damage Retinal Cell Biology
Conclusions. ROCK is a key mediator of TNF-α signaling in diabetic microvessels. The important role of TNF-α in early DR provides a new rationale for ROCK inhibition beyond the previously shown mechanisms.
Source: Investigative Ophthalmology - March 28, 2013 Category: Opthalmology Authors: Arita, R., Nakao, S., Kita, T., Kawahara, S., Asato, R., Yoshida, S., Enaida, H., Hafezi-Moghadam, A., Ishibashi, T. Tags: Retinal Cell Biology Source Type: research

Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Retina
Conclusions. Results presented in this study, for the first time, show that KA-mediated upregulation of SARM1 protein promotes Wallerian-like degeneration of RGCs and their axons.
Source: Investigative Ophthalmology - April 17, 2013 Category: Opthalmology Authors: Massoll, C., Mando, W., Chintala, S. K. Tags: Retina Source Type: research

Effect of VIP on Intracellular Ca2+, Extracellular Regulated Kinase 1/2, and Secretion in Cultured Rat Conjunctival Goblet Cells Cornea
Conclusions. In conclusion, in cultured rat conjunctival goblet cells, VPAC1 and 2 receptors are functional. VIP stimulates a cAMP-dependent increase in [Ca2+]i and glycoconjugate secretion, but not ERK1/2 activation. VIP does not activate with EGFR.
Source: Investigative Ophthalmology - April 23, 2013 Category: Opthalmology Authors: Li, D., Jiao, J., Shatos, M. A., Hodges, R. R., Dartt, D. A. Tags: Cornea Source Type: research

Transcription Factors Runx1 to 3 Are Expressed in the Lacrimal Gland Epithelium and Are Involved in Regulation of Gland Morphogenesis and Regeneration Cornea
Conclusions. Runx1 and 2 are new markers of the LG epithelial lineage and Runx factors are important for normal LG morphogenesis and regeneration.
Source: Investigative Ophthalmology - May 1, 2013 Category: Opthalmology Authors: Voronov, D., Gromova, A., Liu, D., Zoukhri, D., Medvinsky, A., Meech, R., Makarenkova, H. P. Tags: Cornea Source Type: research