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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

Decreased DJ-1 Leads to Impaired Nrf2-Regulated Antioxidant Defense and Increased UV-A-Induced Apoptosis in Corneal Endothelial Cells Cornea
Conclusions. Downregulation of DJ-1 impairs nuclear translocation of Nrf2, causing decreased antioxidant gene expression and increased oxidative damage. The decline in DJ-1 levels leads to heightened CEC susceptibility to UV-A light by activating p53-dependent apoptosis. Targeting the DJ-1–Nrf2 axis may provide a potential therapeutic approach for enhancing antioxidant defense in corneal endothelial disorders.
Source: Investigative Ophthalmology - September 3, 2014 Category: Opthalmology Authors: Liu, C., Chen, Y., Kochevar, I. E., Jurkunas, U. V. Tags: Cornea Source Type: research

Evaluation of Adenovirus-Mediated Down-Regulation of Connective Tissue Growth Factor on Postoperative Wound Healing After Experimental Glaucoma Surgery.
CONCLUSIONS: Down-regulation of CTGF is effective in inhibiting postoperative scarring in vivo. This suggests that RNAi with CTGF siRNA may potentially pave the road for a novel therapeutic strategy to improve glaucoma surgery results. PMID: 26554857 [PubMed - as supplied by publisher]
Source: Current Eye Research - November 10, 2015 Category: Opthalmology Authors: Lim DH, Kim TE, Kee C Tags: Curr Eye Res Source Type: research

Moesin as a key cytoskeleton regulator in corneal fibrosis.
CONCLUSIONS: : Moesin may be a potential drug target for inhibiting corneal fibrosis, and the details of moesin-related signaling pathways would be critical for understanding corneal fibrosis. PMID: 23583046 [PubMed - in process]
Source: The Ocular Surface - April 1, 2013 Category: Opthalmology Authors: Zhu HY, Yeo SW, Ng J, Htoon HM, Beuerman RW Tags: Ocul Surf Source Type: research

Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse model of diabetic retinopathy.
In this study, we used TonEBP heterozygote (±) mice to study the role of TonEBP in streptozotocin (STZ)-induced diabetic retinopathy. We performed immunofluorescence staining and found that retinal expressions of AR and PKCδ were significantly reduced in the heterozygotes compared to wild type littermates, particularly in ganglion cell layer. To examine further the effect of TonEBP reduction in retinal tissues, we performed intravitreal injection of TonEBP siRNA and confirmed the decrease in AR and PKCδ levels. In addition, we found that a proapoptotic factor, Bax level was reduced and a survival factor, Bcl2 level was ...
Source: Experimental Eye Research - March 12, 2014 Category: Opthalmology Authors: Park J, Kim H, Park SY, Lim SW, Kim YS, Lee DH, Roh GS, Kim HJ, Kang SS, Cho GJ, Jeong BY, Kwon HM, Choi WS Tags: Exp Eye Res Source Type: research

Dexamethasone Increases Cdc42 Expression in Human TM-1 Cells.
Conclusions: DEX increases Cdc42 expression in TM-1. This may represent a potential mechanism of DEX-induced HTM cytoskeletal rearrangement. PMID: 24871483 [PubMed - as supplied by publisher]
Source: Current Eye Research - May 28, 2014 Category: Opthalmology Authors: Qiu X, Wu K, Lin X, Liu Q, Ye Y, Yu M Tags: Curr Eye Res Source Type: research

CD147 Required for Corneal Endothelial Lactate Transport Physiology and Pharmacology
Conclusions. CD147 is required for the expression of MCT1 and MCT4 in the corneal endothelium. Silencing CD147 slows lactate efflux, resulting in stromal lactate accumulation and corneal edema, consistent with lactate efflux as a significant component of the corneal endothelial pump.
Source: Investigative Ophthalmology - July 30, 2014 Category: Opthalmology Authors: Li, S., Nguyen, T. T., Bonanno, J. A. Tags: Physiology and Pharmacology Source Type: research

Modulation of VEGF-Induced Retinal Vascular Permeability by Peroxisome Proliferator-Activated Receptor-{beta}/{delta} Retinal Cell Biology
Conclusions. These data suggest a protective effect for PPARβ/ antagonism against VEGF-induced vascular permeability, possibly through reduced VEGFR expression. Therefore, antagonism/reverse agonism of PPARβ/ siRNA may represent a novel therapeutic methodology against retinal hyperpermeability and is worthy of future investigation.
Source: Investigative Ophthalmology - December 18, 2014 Category: Opthalmology Authors: Suarez, S., McCollum, G. W., Bretz, C. A., Yang, R., Capozzi, M. E., Penn, J. S. Tags: Retinal Cell Biology Source Type: research

Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients.
Abstract In studies on dry eye (DE) disease, an association has been identified between tear film hyperosmolarity and inflammation severity elicited through receptor-induced increases in proinflammatory cytokine and chemokine release. These immune reactions might be mediated by inflammasomes, macromolecular complexes mounted around the NLRP3 protein and can be activated by reactive oxygen species (ROS) over-generation. Hence in this study we determine whether: a) ROS activated NLRP3 inflammasomes mediate hyperosmotic stress-induced inflammation in human corneal epithelial cells (HCECs); b) the ROS-NLRP3-IL-1β axi...
Source: Experimental Eye Research - February 18, 2015 Category: Opthalmology Authors: Zheng Q, Ren Y, Reinach PS, Xiao B, Lu H, Zhu Y, Qu J, Chen W Tags: Exp Eye Res Source Type: research

Anoctamin2 (TMEM16B) forms the Ca(2+)-activated Cl(-) channel in the retinal pigment epithelium.
Abstract Chloride channels (Cl channels) play an essential role for the retinal pigment epithelium (RPE). They provide a plasma membrane conductance for Cl(-) important for transepithelial transport and volume regulation. Ca(2+)-dependent chloride channels (CaCC) in the RPE were found to adapt Cl(-) transport to specific needs by increasing intracellular free Ca(2+). Although a variety of Cl channels have been identified in the RPE, the molecular identity of the CaCC remains controversial. Sagittal sections of mouse retina were stained against anoctamin2 (Ano2) and analyzed by confocal microscopy. Membrane current...
Source: Experimental Eye Research - December 7, 2016 Category: Opthalmology Authors: Keckeis S, Reichhart N, Roubeix C, Strauß O Tags: Exp Eye Res Source Type: research

Silencing of p53 reduces cell migration in human Tenon's fibroblasts induced by TGF- β
Conclusionsp53 inhibited expression of TGF- β, suppressed HTFs migration and inhibited HTFs growth, by reducing miR-29b expression and interacting with miR29b gene in HTFs.
Source: International Ophthalmology - March 1, 2020 Category: Opthalmology Source Type: research

Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research