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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

Role of Glutathione Peroxidase 4 in Corneal Endothelial Cells.
CONCLUSION: These results suggest that GPx4 is an important antioxidant enzyme for maintaining redox status and protecting corneal endothelial cells from oxidative stress. PMID: 27420751 [PubMed - as supplied by publisher]
Source: Current Eye Research - July 14, 2016 Category: Opthalmology Authors: Uchida T, Sakai O, Imai H, Ueta T Tags: Curr Eye Res Source Type: research

Development of Allele-Specific Gene-Silencing siRNAs for TGFBI Arg124Cys in Lattice Corneal Dystrophy Type I Cornea
Conclusions. We have identified a lead siRNA specific to the TGFBI-Arg124Cys mutant allele associated with LCDI. Silencing of exogenous TGFBI was observed at mRNA and protein levels, and in an ex vivo model of LCDI with an efficient suppression of the endogenous mutant allele. This result indicates the potential of siRNA treatment as a personalized medicine approach for the management of heritable TGFBI-associated corneal dystrophies.
Source: Investigative Ophthalmology - February 18, 2014 Category: Opthalmology Authors: Courtney, D. G., Atkinson, S. D., Moore, J. E., Maurizi, E., Serafini, C., Pellegrini, G., Black, G. C., Manson, F. D., Yam, G. H. F., MacEwen, C. J., Allen, E. H. A., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research

Beta2 adrenergic receptor silencing change intraocular pressure in New Zealand rabbits
Conclusion The use of siRNA against the beta2 adrenergic receptors could provide an interesting therapeutic strategy for glaucoma treatment.
Source: Journal of Optometry - November 11, 2017 Category: Opthalmology Source Type: research

Black carbon induces complement activation via NLRP3 inflammasome in human corneal epithelial cells
CONCLUSIONS: BC particles, including FBC and OBC, triggered complement activation, increasing the protein level of C5b-9 in cultured HCECs. siRNA targeting NLRP3 to inhibit NLRP3 generation reduced C5b-9 protein level in HCECs treated with FBC or OBC particles, indicating that BC induces complement activation potentially through the NLRP3 inflammasome in HCECs.PMID:34375537 | DOI:10.1080/02713683.2021.1967404
Source: Current Eye Research - August 10, 2021 Category: Opthalmology Authors: Qin Long Liqiang Wang Jing Shang Ying Liu Chen Chen Source Type: research

Triple Combination of siRNAs Targeting TGF{beta}1, TGF{beta}R2, and CTGF Enhances Reduction of Collagen I and Smooth Muscle Actin in Corneal Fibroblasts Cornea
Conclusions. Simultaneous targeting of TGFβ1, TGFβR2, and CTGF genes by effective triple siRNA combination produced high knockdown of target and downstream scarring genes without cell toxicity, which may have clinical applications in reducing corneal fibrosis and scarring in other tissues.
Source: Investigative Ophthalmology - December 17, 2013 Category: Opthalmology Authors: Sriram, S., Robinson, P., Pi, L., Lewin, A. S., Schultz, G. Tags: Cornea Source Type: research

Beta2 adrenergic receptor silencing change intraocular pressure in New Zealand rabbits
ConclusionThe use of siRNA against the beta2 adrenergic receptors could provide an interesting therapeutic strategy for glaucoma treatment.ResumenObjetivoEl glaucoma consiste en un grupo de neuropatías ópticas progresivas caracterizadas por degeneración del nervio óptico y pérdida irreversible del campo visual. La elevación de la presión intraocular es el único factor de riesgo tratable probado, centrándose los productos comerciales para el tratamiento del glaucoma en la reducción de la presión intraocular. Estos fármacos pueden tener diversos efectos secundarios indeseados, lo cual invita a buscar nuevas estra...
Source: Journal of Optometry - July 5, 2018 Category: Opthalmology Source Type: research

Investigating impacts of surface charge on intraocular distribution of intravitreal lipid nanoparticles.
Abstract In this paper, the effect of surface charge of intravitreal lipid nanoparticles (LNPs) on their intraocular accumulation and distribution was quantitatively and systematically studied. The retinal distribution of LNPs delivering model drug (siRNA) with optimal surface charge was visualized as well. LNPs and siRNA-loaded LNPs (siLNPs) were prepared with ethanol-injection method. C57BL/6 Mice with the age of 6-8 weeks were used for the animal experiments. Quantitative accumulation in the eye and respective intraocular distribution of the intravitreally injected LNPs with different surface charge were examin...
Source: Experimental Eye Research - June 21, 2019 Category: Opthalmology Authors: Huang X, Chau Y Tags: Exp Eye Res Source Type: research

Decreased FABP5 and DSG1 protein expression following PAX6 knockdown of differentiated human limbal epithelial cells
Exp Eye Res. 2021 Dec 23:108904. doi: 10.1016/j.exer.2021.108904. Online ahead of print.ABSTRACTPAX6 haploinsufficiency related aniridia is characterized by disorder of limbal epithelial cells (LECs) and aniridia related keratopathy. In the limbal epithelial cells of aniridia patients, deregulated retinoic acid (RA) signaling components were identified. We aimed to visualize differentiation marker and RA signaling component expression in LECs, combining a differentiation triggering growth condition with a small interfering RNA (siRNA) based aniridia cell model (PAX6 knock down). Primary LECs were isolated from corneosclera...
Source: Experimental Eye Research - December 26, 2021 Category: Opthalmology Authors: Priya Katiyar Tanja Stachon Fabian N Fries Frederika Parow Myriam Ulrich Achim Langenbucher Alan Cayless Berthold Seitz Barbara K äsmann-Kellner Lorenz Latta N óra Szentmáry Source Type: research

Effects of High Glucose-Induced Cx43 Downregulation on Occludin and ZO-1 Expression and Tight Junction Barrier Function in Retinal Endothelial Cells Retinal Cell Biology
Conclusions. Our findings indicate that HG-induced downregulation of Cx43 expression and GJIC may contribute to the breakdown of endothelial barrier tight junctions associated with diabetic retinopathy.
Source: Investigative Ophthalmology - October 3, 2013 Category: Opthalmology Authors: Tien, T., Barrette, K. F., Chronopoulos, A., Roy, S. Tags: Retinal Cell Biology Source Type: research

Knockdown of Both p120 Catenin and Kaiso Promotes Expansion of Human Corneal Endothelial Monolayers via RhoA-ROCK-Noncanonical BMP-NF{kappa}B Pathway Cornea
Conclusions. The optimized knockdown with p120 and Kaiso siRNAs further expands the size of HCEC monolayers without endothelial mesenchymal transition (EMT) via selective activation of p120/Kaiso signaling that requires the RhoA-ROCK-noncanonical BMP-NFkB signaling.
Source: Investigative Ophthalmology - March 13, 2014 Category: Opthalmology Authors: Zhu, Y.-T., Han, B., Li, F., Chen, S.-Y., Tighe, S., Zhang, S., Tseng, S. C. G. Tags: Cornea Source Type: research