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Specialty: Opthalmology

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Total 178 results found since Jan 2013.

Inhibition of Drp1 ameliorates diabetic retinopathy by regulating mitochondrial homeostasis
Exp Eye Res. 2022 Apr 28:109095. doi: 10.1016/j.exer.2022.109095. Online ahead of print.ABSTRACTDiabetic retinopathy (DR) is a potentially blinding complication resulting from diabetes mellitus (DM). Retinal vascular endothelial cells (RMECs) dysfunction occupies an important position in the pathogenesis of DR, and mitochondrial disorders play a vital role in RMECs dysfunction. However, the detailed mechanisms underlying DR-induced mitochondrial disorders in RMECs remain elusive. In the present study, we used High glucose (HG)-induced RMECs in vitro and streptozotocin (STZ)-induced Sprague-Dawley rats in vivo to explore th...
Source: Experimental Eye Research - May 1, 2022 Category: Opthalmology Authors: Meng-Yuan Zhang Lingpeng Zhu Xun Bao Tian-Hua Xie Jiping Cai Jian Zou Wenjuan Wang Shun Gu Yan Li Hong-Ying Li Yong Yao Ting-Ting Wei Source Type: research

TNFAIP3 may be key to TLR4-activation of the inflammasome in the retinal vasculature
Exp Eye Res. 2022 May 11:109108. doi: 10.1016/j.exer.2022.109108. Online ahead of print.ABSTRACTThe goal of these studies were to determine whether tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) regulated toll-like receptor 4 (TLR4) actions on the NOD-like receptor protein 3 (NLRP3) inflammasome. Western blotting was done on retinal lysates from TLR4 floxed and endothelial cell specific TLR4 knockout mice for TNFAIP3, TLR4, and NLRP3 pathway proteins. Retinal endothelial cells (REC) were grown in normal (5mM) and high glucose (25mM) and treated with TNFAIP3 siRNA, followed by Western blotting for TLR4 and NLRP3 p...
Source: Experimental Eye Research - May 14, 2022 Category: Opthalmology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research

Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function
Exp Eye Res. 2022 May 29:109129. doi: 10.1016/j.exer.2022.109129. Online ahead of print.ABSTRACTPreservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our prior studies demonstrate the importance of hydroxycarboxylic acid receptor 2/GPR109A (HCAR2/GPR109A) expression in the retinal pigment epithelium (RPE) to outer retinal barrier integrity. However, whether HCAR2/GPR109A is expressed in retinal endothelial cells and has a similar relati...
Source: Experimental Eye Research - June 1, 2022 Category: Opthalmology Authors: Ammar A Abdelrahman Folami L Powell Ravirajsinh N Jadeja Malita A Jones Menaka C Thounaojam Manuela Bartoli Mohamed Al-Shabrawey Pamela M Martin Source Type: research

Glabridin Inhibits < em > Aspergillus fumigatus < /em > Growth and Alleviate Inflammation Mediated by Dectin-2 and NLRP3 Inflammasome
CONCLUSION: Glabridin plays an anti-inflammatory role in A. fumigatus challenge via suppression of the Dectin-2 and NLRP3 inflammasome, and plays an anti-fungal role through delaying germination and changing the hyphal integrity.KEY MESSAGESGlabridin plays an anti-inflammatory role in A. fumigatus infection of RAW264.7 cells in a concentration-dependent manner and through Dectin-2 mediation.Glabridin decreases fungal distribution and inflammation in mouse A. fumigatus keratitis.Glabridin inhibits A. fumigatus growth by delaying germination and disrupting cellular structure in vitro.PMID:36785524 | DOI:10.1080/02713683.2022.2164779
Source: Current Eye Research - February 14, 2023 Category: Opthalmology Authors: Lu Zhan Xue Tian Jing Lin Xudong Peng Guiqiu Zhao Source Type: research

Inhibition of AIF-1 alleviates laser-induced macular neovascularization by inhibiting endothelial cell proliferation via restrained p44/42 MAPK signaling pathway
This study aimed to understand how AIF-1 effects the proliferation of CECs and the subsequent progression of MNV. To study this, a mouse MNV model was established through laser injury, and the AIF-1 expression levels were then measured using western blot and immunohistochemistry. AIF-1 siRNA was intravitreally injected to silence AIF-1 gene expression. Western blot and choroidal flat mount were performed to measure the progression of MNV and proliferation of the CECs. These results showed that the protein expression of AIF-1 was significantly elevated in the laser-induced mouse MNV model, and the expression trend was consi...
Source: Experimental Eye Research - April 18, 2023 Category: Opthalmology Authors: Qinghua Li Liting Hu Guibo Liu Xiaoni Yin Ying Li Xiangyang Wei Ning Duan Xiaoran Zhao Qingyun Gong Zhaodong Du Source Type: research

ERK5 Regulates Glucose-Induced Increased Fibronectin Production in the Endothelial Cells and in the Retina in Diabetes Retina
Conclusions. Our experiments demonstrated a novel mechanism of glucose-induced increased FN production in diabetic retinopathy, which is mediated through decreased ERK5 signaling.
Source: Investigative Ophthalmology - December 19, 2012 Category: Opthalmology Authors: Wu, Y., Feng, B., Chen, S., Chakrabarti, S. Tags: Retina Source Type: research

Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation Retinal Cell Biology
Conclusions. Histone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression. Targeting enzymes important for histone methylation may serve as a potential therapy to halt the development of diabetic retinopathy.
Source: Investigative Ophthalmology - January 14, 2013 Category: Opthalmology Authors: Zhong, Q., Kowluru, R. A. Tags: Retinal Cell Biology Source Type: research

TGF{beta} Signaling Induces Expression of Gadd45b in Retinal Ganglion Cells Biochemistry and Molecular Biology
Conclusions. TGFβ signaling induced Gadd45b expression in RGCs. Modulation of the TGFβ/NFB/Gadd45b signaling pathway may provide a means to enhance the neuroprotective effect of Gadd45b in RGCs.
Source: Investigative Ophthalmology - February 5, 2013 Category: Opthalmology Authors: Liu, B., Sun, X., Suyeoka, G., Garcia, J. G. N., Leiderman, Y. I. Tags: Biochemistry and Molecular Biology Source Type: research

MRP8/14 Enhances Corneal Susceptibility to Pseudomonas aeruginosa Infection by Amplifying Inflammatory Responses Immunology and Microbiology
Conclusions. Our study demonstrated a dual role for MRP8/14 in bacterial keratitis. Although MRP8/14 promotes bacterial clearance by enhancing ROS production, it functions more importantly as an inflammatory amplifier at the ocular surface by enhancing pro-inflammatory cytokine expression, thus contributing to the corneal susceptibility.
Source: Investigative Ophthalmology - February 12, 2013 Category: Opthalmology Authors: Deng, Q., Sun, M., Yang, K., Zhu, M., Chen, K., Yuan, J., Wu, M., Huang, X. Tags: Immunology and Microbiology Source Type: research