Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation [Retinal Cell Biology]

Conclusions. Histone methylation of retinal Sod2 has an important role in the development of diabetic retinopathy and in the metabolic memory phenomenon associated with its continued progression. Targeting enzymes important for histone methylation may serve as a potential therapy to halt the development of diabetic retinopathy.

http://www.iovs.org/cgi/content/full/54/1/244?rss=1

Source: Investigative Ophthalmology - January 14, 2013 Category: Opthalmology Authors: Zhong, Q., Kowluru, R. A. Tags: Retinal Cell Biology Source Type: research