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Specialty: Nanotechnology

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Total 382 results found since Jan 2013.

Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke Therapy
Source: Journal of Biomedical Nanotechnology - November 22, 2019 Category: Nanotechnology Authors: Kim, Minkyung Kim, Gyeungyun Hwang, Do Won Lee, Minhyung Tags: Articles Source Type: research

Enriched chitosan nanoparticles loaded with siRNA are effective in lowering Huntington's disease gene expression following intranasal administration
Publication date: Available online 27 October 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Vasyl Sava, Oksana Fihurka, Anastasia Khvorova, Juan Sanchez-RamosAbstractTherapies to lower gene expression in brain disease currently require chronic administration into the cerebrospinal fluid (CSF) by intrathecal infusions or direct intracerebral injections. Though well-tolerated in the short-term, this approach is not tenable for a life-time of administration. Nose-to-brain delivery of enriched chitosan-based nanoparticles loaded with anti-HTT siRNA was studied in a transgenic YAC128 mouse model of Hu...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 28, 2019 Category: Nanotechnology Source Type: research

Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decreased intestinal...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 16, 2019 Category: Nanotechnology Source Type: research

ASAP Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury
ACS NanoDOI: 10.1021/acsnano.9b01892
Source: ACS Nano - August 29, 2019 Category: Nanotechnology Authors: Shaowei Guo †‡, Nisim Perets§, Oshra Betzer?, Shahar Ben-Shaul†, Anton Sheinin§, Izhak Michaelevski?, Rachela Popovtzer?, Daniel Offen§#, and Shulamit Levenberg*† Source Type: research

EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer
Nanomedicine, Ahead of Print.
Source: Nanomedicine - August 20, 2019 Category: Nanotechnology Authors: Elif Asik Yeliz Akpinar Ayse Caner Nermin Kahraman Tulin Guray Murvet Volkan Constance Albarracin Apar Pataer Banu Arun Bulent Ozpolat Source Type: research

Single-Cell Kinetics of siRNA-Mediated mRNA Degradation
Publication date: Available online 8 August 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Rafał Krzysztoń, Daniel Woschée, Anita Reiser, Gerlinde Schwake, Helmut H. Strey, Joachim O. RädlerAbstractRNA interference (RNAi) enables the therapeutic use of small interfering RNAs (siRNAs) to silence disease-related genes. The efficiency of silencing is commonly assessed by measuring expression levels of the target protein at a given time point post-transfection. Here, we determine the siRNA-induced fold change in mRNA degradation kinetics from single-cell fluorescence time-courses obtained using li...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - August 8, 2019 Category: Nanotechnology Source Type: research

ASAP Stimuli-Responsive Polymer –Prodrug Hybrid Nanoplatform for Multistage siRNA Delivery and Combination Cancer Therapy
Nano LettersDOI: 10.1021/acs.nanolett.9b01660
Source: Nano Letters - August 7, 2019 Category: Nanotechnology Authors: Phei Er Saw †‡, Herui Yao†‡, Chunhao Lin†‡, Wei Tao§, Omid C Farokhzad*§, and Xiaoding Xu*†‡ Source Type: research

Nanoparticle-siRNA: a potential strategy for ovarian cancer therapy?
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - July 31, 2019 Category: Nanotechnology Authors: Shahin Aghamiri Keyvan Fallah Mehrjardi Sasan Shabani Mahsa Keshavarz-Fathi Saeed Kargar Nima Rezaei Source Type: research

Nanowire-array-based gene electro-transfection system driven by human-motion operated triboelectric nanogenerator
Publication date: Available online 15 July 2019Source: Nano EnergyAuthor(s): Chengbin Yang, Guang Yang, Qingling Ouyang, Shuangyang Kuang, Peiyi Song, Gaixia Xu, Daniel Puiu Poenar, Guang Zhu, Ken-Tye Yong, Zhong Lin WangAbstractElectro-transfection serves as a promising non-viral gene delivery approach, but its performance faces several drawbacks associated with the high-voltage electrical pulses involved, which may adversely affect the cell viability. Here we developed a novel TENG (triboelectric nanogenerator)-driven nanowire electrode array (T-NEA) platform to facilitate the electroporation-based siRNA delivery into bo...
Source: Nano Energy - July 17, 2019 Category: Nanotechnology Source Type: research

siRNA nanotherapeutics: a promising strategy for anti-HBV therapy
Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC) and liver cirrhosis worldwide. In spite of the numerous advances in the treatment of CHB, drugs and vaccines have failed because of many factors like complexity, resistance, toxicity, and heavy cost. New RNA interference (RNAi)-based technologies have developed innovative strategies to target Achilles' heel of the several hazardous diseases involving cancer, some genetic disease, autoimmune illnesses, and viral disorders particularly hepatitis B virus (HBV) infections. Naked siRNA delivery has serious challenges including failure to cross ...
Source: IET Nanobiotechnology - June 21, 2019 Category: Nanotechnology Source Type: research

Multifunctional Polymeric Carrier for Co-Delivery of MRI Contrast Agents and siRNA to Tumors
Source: Journal of Biomedical Nanotechnology - June 21, 2019 Category: Nanotechnology Authors: Gao, Haiyan Feng, Huayang Bai, Yan Li, Zhanrong Chen, Lijuan Jin, Lin Wang, Junfeng Georges, El Fakhri Liu, Gang Li, Jingguo Wang, Meiyun Tags: Articles Source Type: research

Sequential Targeting TGF ‐β Signaling and KRAS Mutation Increases Therapeutic Efficacy in Pancreatic Cancer
Fraxinellone ‐loaded CGKRK‐modified nanoparticles are prepared for regulating transforming growth factor beta signals in the suppressive tumor microenvironment. Based on this, the dense stroma is modulated and the intratumor blood perfusion is enhanced, meaning the delivery barrier of the following siRNA ‐loaded lipid‐coated calcium phosphate (LCP) biomimetic high‐density lipoprotein nanoparticles (siKras‐LCP‐ApoE3) are internalized and specifically silence KRAS mutation and kill cancer cells. AbstractPancreatic cancer is a highly aggressive malignancy that strongly resists extant treatments. The failure of e...
Source: Small - June 13, 2019 Category: Nanotechnology Authors: Yuanyuan Pei, Liang Chen, Yukun Huang, Jiahao Wang, Jingxian Feng, Minjun Xu, Yu Chen, Qingxiang Song, Gan Jiang, Xiao Gu, Qian Zhang, Xiaoling Gao, Jun Chen Tags: Full Paper Source Type: research

Sterically stabilized siRNA:gold nanocomplexes enhance c-MYC silencing in a breast cancer cell model
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - June 4, 2019 Category: Nanotechnology Authors: Aliscia N Daniels Moganavelli Singh Source Type: research