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Total 382 results found since Jan 2013.

Synthetic siRNA targeting human papillomavirus 16 E6: a perspective on in vitro nanotherapeutic approaches
Nanomedicine,Volume 13, Issue 4, Page 455-474, February 2018.
Source: Future Medicine: Nanomedicine - January 31, 2018 Category: Nanotechnology Authors: Melissa Togtema Robert Jackson Jessica Grochowski Peter L Villa Miranda Mellerup Jyoti Chattopadhyaya Ingeborg Zehbe Source Type: research

Balancing Biocompatibility, Internalization and Pharmacokinetics of Polycations/siRNA by Structuring the Weak Negative Charged Ternary Complexes with Hyaluronic Acid
Source: Journal of Biomedical Nanotechnology - January 11, 2018 Category: Nanotechnology Authors: Zhou, Junhui Song, Xinyun Han, Shangcong Wei, Tuo Wang, Xiaoxia Cao, Huiqing Liang, Xing-Jie Liang, Zicai Cheng, Qiang Deng, Liandong Dong, Anjie Tags: Research Articles Source Type: research

Paraptosis ‐Inducing Nanomedicine Overcomes Cancer Drug Resistance for a Potent Cancer Therapy
Abstract Most chemotherapeutic drugs and their nanomedicine formulations exert anticancer activity by inducing cancer cell apoptosis. However, cancer cells inherently have and acquire many antiapoptosis mechanisms, causing cancer drug resistance and poor prognoses in patients. Herein, a potent paraptosis‐inducing nanomedicine is reported that causes quick nonapoptotic death of cancer cells, overcoming apoptosis‐based resistance and effectively inhibiting drug‐resistant tumor growth. The nanomedicine is composed of micelles made from an amphiphilic 8‐hydroxyquinoline (HQ)‐conjugate block copolymer with polyethylen...
Source: Small - January 1, 2018 Category: Nanotechnology Authors: Yongcun Zhou, Feiteng Huang, Ying Yang, Pingli Wang, Zhen Zhang, Yining Tang, Youqing Shen, Kai Wang Tags: Full Paper Source Type: research

Atom Transfer Radical Polymerization of Multishelled Cationic Corona for the Systemic Delivery of siRNA
Nano LettersDOI: 10.1021/acs.nanolett.7b04183
Source: Nano Letters - December 18, 2017 Category: Nanotechnology Authors: Hye Sung Kim, Young Ju Son, Wei Mao, Kam W. Leong and Hyuk Sang Yoo Source Type: research

The Effects of Biological Fluids on Colloidal Stability and siRNA Delivery of a pH-Responsive Micellar Nanoparticle Delivery System
ACS NanoDOI: 10.1021/acsnano.7b05528
Source: ACS Nano - December 15, 2017 Category: Nanotechnology Authors: Dominic W. Malcolm, Jomy J. Varghese, Janet E. Sorrells, Catherine E. Ovitt and Danielle S. W. Benoit Source Type: research

Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - December 4, 2017 Category: Nanotechnology Authors: Achim Aigner Donat K ögel Source Type: research

Self ‐Assembled Aptamer‐Nanomedicine for Targeted Chemotherapy and Gene Therapy
In this study, a multifunctional aptamer‐nanomedicine (Apt‐NMed) achieving targeted chemotherapy and gene therapy of ALCL is developed. Apt‐NMed is formulated by self‐assembly of synthetic oligonucleotides containing CD30‐specific aptamer and anaplastic lymphoma kinase (ALK)‐specific siRNA followed by self‐loading of the chemotherapeutic drug doxorubicin (DOX). Apt‐NMed exhibits a well‐defined nanostructure (diameter 59 mm) and stability in human serum. Under aptamer guidance, Apt‐NMed specifically binds and internalizes targeted ALCL cells. Intracellular delivery of Apt‐NMed triggers rapid DOX releas...
Source: Small - December 4, 2017 Category: Nanotechnology Authors: Nianxi Zhao, Zihua Zeng, Youli Zu Tags: Full Paper Source Type: research

Nanoparticle/siRNA-based therapy strategies in glioma: which nanoparticles, which siRNAs?
Nanomedicine, Ahead of Print.
Source: Nanomedicine - December 4, 2017 Category: Nanotechnology Authors: Achim Aigner Donat K ögel Source Type: research

Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment
Publication date: Available online 16 November 2017 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Narsireddy Amreddy, Anish Babu, Janani Panneerselvam, Akhil Srivastava, Ranganayaki Muralidharan, Allshine Chen, Yan D. Zhao, Anupama Munshi, Rajagopal Ramesh Co-administration of functionally distinct anti-cancer agents has emerged as an efficient strategy in lung cancer treatment. However, a specially designed drug delivery system is required to co-encapsulate functionally different agents, such as a combination of siRNA and chemotherapy, for targeted delivery. We developed a folic acid (FA) -conjugat...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 28, 2017 Category: Nanotechnology Source Type: research

Amphiphilic poly( α)glutamate polymeric micelles for systemic administration of siRNA to tumors
RNAi therapeutics carried a great promise to the area of personalized medicine: the ability to target “undruggable” oncogenic pathways. Nevertheless, their efficient tumor targeting via systemic administration had not been resolved yet. Amphiphilic alkylated poly(α)glutamate amine (APA) can serve as a cationic carrier to the negatively-charged oligonucleotides. APA polymers complexed with siRNA to form round-shaped, homogenous and reproducible nano-sized polyplexes bearing ~50nm size and slightly negative charge.
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 7, 2017 Category: Nanotechnology Authors: Adva Krivitsky, Dina Polyak, Anna Scomparin, Shay Eliyahu, Paula Ofek, Galia Tiram, Hagar Kalinski, Sharon Avkin-Nachum, Nat àlia Feiner Gracia, Lorenzo Albertazzi, Ronit Satchi-Fainaro Source Type: research

Oral siRNA Delivery to Treat Colorectal Liver Metastases
ACS NanoDOI: 10.1021/acsnano.7b05547
Source: ACS Nano - October 13, 2017 Category: Nanotechnology Authors: Sung Hun Kang, Vishnu Revuri, Sang-Joon Lee, Sungpil Cho, In-Kyu Park, Kwang Jae Cho, Woo Kyun Bae and Yong-kyu Lee Source Type: research

Inhibition Activity of Herpes Virus (HSV) Replication by & #945;-TIF siRNA-Loaded PLGA-TPGS Nanoparticles In Vitro and In Viv
Source: Journal of Biomedical Nanotechnology - September 27, 2017 Category: Nanotechnology Authors: Wang, Kebing Yang, Chengming Ye, Jiajun Zeng, Fanqi Duan, Yanling Zheng, Yi Hu, Bo Yu, Xilan Tags: Research Articles Source Type: research