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Specialty: Nanotechnology
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Total 382 results found since Jan 2013.
Lipid-coated albumin-paclitaxel nanoparticles loaded with sorcin-siRNA reverse cancer chemoresistance via restoring intracellular calcium ion homeostasis
Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...
Source: Journal of Nanobiotechnology - July 7, 2022 Category: Nanotechnology Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu Tags: Research Source Type: research
Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy
Aleuria aurantia lectin (AAL) and β-amyploid (Aβ)-binding peptides (KLVFF) modified PEGylated dendrigraft poly-L-lysines (DGLs) encapsulate small interfering RNA of β-site precursor protein (APP) cleaving enzyme-1 (BACE1 siRNA) and rapamycin for Alzheimer's disease (AD) treatment by nasal administration. Dual target modific ation increases about 1.4-fold of drug accumulation in the brain. Furthermore, the combination of BACE1 siRNA, rapamycin, and KLVFF greatly improves the cognition of transgenic AD mice. AbstractAlzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most univer...
Source: Small - June 30, 2022 Category: Nanotechnology Authors: Xiaotong Yang,
Wenqin Yang,
Xue Xia,
Ting Lei,
Zhihang Yang,
Wenfeng Jia,
Yang Zhou,
Guo Cheng,
Huile Gao Tags: Research Article Source Type: research
Siglec15 Checkpoint Blockade for Simultaneous Immunochemotherapy and Osteolysis Inhibition in Lung Adenocarcinoma Spinal Metastasis via a Hollow Nanoplatform
According to the high expression of Siglec15 in lung adenocarcinoma spinal metastasis (LUAD-SM), an actively targeted tumor microenvironment (TME)-responsive hollow MnO2 nanoplatform is designed for enhanced synergetic immunochemotherapy and osteolysis inhibition via downregulation of Siglec15 in both tumor cells and tumor-associated macrophages. Such a nanoplatform can provide a strategy for “killing two birds with one stone” to treat LUAD-SM. AbstractLow responsiveness to anti-programmed death-1/programmed death-ligand 1 (anti-PD-1/PD-L1) for solid tumors indicates the presence of other immunosuppressive pathways. Si...
Source: Small - June 25, 2022 Category: Nanotechnology Authors: Haifeng Liang,
Lei Zhou,
Zhichao Hu,
Yuxiang Ge,
Taiwei Zhang,
Qing Chen,
Ben Wang,
Shunyi Lu,
Wang Ding,
Jian Dong,
Fengfeng Xue,
Libo Jiang Tags: Research Article Source Type: research
Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy
An active targeting nanomedicine based on metal-organic frameworks is synthesized through coordination between tannic acid and Fe3+, loaded with anti-TNF- α siRNA and then modified with bovine serum albumin. The nanosystem can selectively accumulate in inflamed joints, be selectively delivered into M1 macrophages, and exert anti-RA efficacy through the synergistic effects between MOF vector and anti-TNF-α siRNA. AbstractMacrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into the pro-inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Here...
Source: Small - June 3, 2022 Category: Nanotechnology Authors: Lina Guo,
Shenghui Zhong,
Peng Liu,
Man Guo,
Jinsong Ding,
Wenhu Zhou Tags: Research Article Source Type: research
Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis (Small 11/2022)
Breast Cancer TreatmentIn article number2107550, Wassana Yantasee and co-workers develop polymer-decorated mesoporous silica nanoparticles for HER2-positive breast cancer treatment. This patented versatile platform can co-deliver multiple therapeutic classes to ensure that they reach the target cells at the same time to fully realize their synergy. Illustrated herein are nanoparticles with three drug cargos: HER2 antibody, HER2 siRNA, and chemotherapeutic docetaxel.
Source: Small - March 17, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul,
Daniel S. Bejan,
William Cruz ‐Muñoz,
Moataz Reda,
Husam Y. Zaidan,
Natnaree Siriwon,
Suphalak Marshall,
Ruijie Wang,
Molly A. Nelson,
Justin P. C. Rehwaldt,
Joe W. Gray,
Kullervo Hynynen,
Wassana Yantasee Tags: Cover Picture Source Type: research
IR792-MCN@ZIF-8-PD-L1 siRNA drug delivery system enhances photothermal immunotherapy for triple-negative breast cancer under near-infrared laser irradiation
Despite extensive investigations on photothermal therapy, the clinical application is restricted due to poor stability, low therapeutic efficacy of photothermal therapy agents and its affinity loss in the mult...
Source: Journal of Nanobiotechnology - March 2, 2022 Category: Nanotechnology Authors: Yongmei Wang, Haibo Wang, Yuhua Song, Meng Lv, Yan Mao, Hongming Song, Yuanyuan Wang, Gang Nie, Xiaoyi Liu, Jian Cui and Xueqing Zou Tags: Research Source Type: research
Synergistic Silencing of Skp2 by siRNA Self ‐Assembled Nanoparticles as a Therapeutic Strategy for Advanced Prostate Cancer
Carrier-free delivery of siRNA targeting oncogenicSkp2 is achieved by self-assembly of siSkp2 with quercetin (Que) into nanoparticle. The constructed siSkp2/Que nanoparticles exhibit a synergistic silencing effect by simultaneous degradation of mRNA and protein ofSkp2, leading to apoptosis and proliferation inhibition in advanced prostate cancer cells both in vitro and in vivo. AbstractAdvanced prostate cancer, harboring multiple mutations of tumor suppressor genes, is refractory to conventional therapies. Knockout of theSkp2 gene blocks pRb/p53 doubly deficient prostate cancer in mice, which inspired the authors to develo...
Source: Small - February 19, 2022 Category: Nanotechnology Authors: Hong Liang,
Fangming Zhang,
Yannv Hong,
Yue Wu,
Huanzhang Xie,
Chen Zhang,
Zonghua Wang,
Zhonglei Lu,
Huanghao Yang Tags: Research Article Source Type: research
Targeted Nanoparticle for Co ‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis
This research paper describes a new therapeutic candidate based on a nanoparticle that co-delivers siRNA against human epidermal growth factor receptor type 2 (HER2), trastuzumab, and docetaxel to treat advanced HER2+ breast cancer. The nanotherapeutic is more effective and safer than the free drug counterparts. It inhibits drug-resistant orthotopic and brain-metastatic HER2+ breast tumors in mice. AbstractThe first-line treatment of advanced and metastatic human epidermal growth factor receptor type 2 (HER2+) breast cancer requires two HER2-targeting antibodies (trastuzumab and pertuzumab) and a taxane (docetaxel or pacli...
Source: Small - January 27, 2022 Category: Nanotechnology Authors: Worapol Ngamcherdtrakul,
Daniel S. Bejan,
William Cruz ‐Muñoz,
Moataz Reda,
Husam Y. Zaidan,
Natnaree Siriwon,
Suphalak Marshall,
Ruijie Wang,
Molly A. Nelson,
Justin P. C. Rehwaldt,
Joe W. Gray,
Kullervo Hynynen,
Wassana Yantasee Tags: Research Article Source Type: research
Rad51 Silencing with siRNA Delivered by Porous Silicon-Based Microparticle Enhances the Anti-Cancer Effect of Doxorubicin in Triple-Negative Breast Cancer
Source: Journal of Biomedical Nanotechnology - January 2, 2022 Category: Nanotechnology Authors: Wu, Zeliang Zhu, Lin Mai, Junhua Shen, Haifa Xu, Rong Tags: research-article Source Type: research
Multifunctional Nanoparticles Loaded with Vascular Endothelial Growth Factor Inhibitors and MED1 siRNA to Inhibit Breast Cancer Progression by Targeting Tumor-Associated Macrophages and Breast Cancer Cells
Source: Journal of Biomedical Nanotechnology - January 2, 2022 Category: Nanotechnology Authors: Wang, Song Luo, Zifeng Zhou, Xinke Wang, Chong Luo, Yuanwei Yi, Nian Liao, Yu Ling Tags: research-article Source Type: research
Targeted siRNA nanotherapeutics against breast and ovarian metastatic cancer: a comprehensive review of the literature
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - December 21, 2021 Category: Nanotechnology Authors: Abdus Subhan Sara Aly Attia Vladimir P Torchilin Source Type: research
