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Specialty: Nanotechnology
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Total 382 results found since Jan 2013.
ASAP Engineered Polymer –siRNA Polyplexes Provide Effective Treatment of Lung Inflammation
ACS NanoDOI: 10.1021/acsnano.2c08690
Source: ACS Nano - February 20, 2023 Category: Nanotechnology Authors: Taewon Jeon ζ, David C. Lutherζ, Ritabrita Goswamiζ, Charlotte Bell, Harini Nagarajζ, Yagiz Anil Cicekζ, Rui Huangζ, Javier A. Mas-Rosario, James L. Eliaζ, Jungkyun Imζ, Yi-Wei Leeζ, Yuanchang Liuζ, Federica Scalettiζ, Michelle E. Farkasζ, Jes Source Type: research
Effective treatment of retinal neovascular leakage with fusogenic porous silicon nanoparticles delivering VEGF-siRNA
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - February 7, 2023 Category: Nanotechnology Authors: Joel F Grondek Kristyn Huffman Ella Jiyoon Lee Melina Cavichini Alexandra Warter Fritz Gerald P Kalaw Anna Heinke Ruhan Fan Lingyun Cheng Michael J Sailor William R Freeman Source Type: research
Edible and cation-free kiwi fruit derived vesicles mediated EGFR-targeted siRNA delivery to inhibit multidrug resistant lung cancer
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative b...
Source: Journal of Nanobiotechnology - February 5, 2023 Category: Nanotechnology Authors: Haoying Huang, Xiaohan Yi, Qingyun Wei, Mengyuan Li, Xueting Cai, Yan Lv, Ling Weng, Yujie Mao, Weiwei Fan, Mengmeng Zhao, Zhongpei Weng, Qing Zhao, Kewei Zhao, Meng Cao, Jing Chen and Peng Cao Tags: Research Source Type: research
A pH-responsive metal-organic framework for the co-delivery of HIF-2 α siRNA and curcumin for enhanced therapy of osteoarthritis
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the...
Source: Journal of Nanobiotechnology - January 17, 2023 Category: Nanotechnology Authors: Zi-Jian Zhang, Ying-Ke Hou, Ming-Wa Chen, Xue-Zhao Yu, Si-Yu Chen, Ya-Ru Yue, Xiong-Tian Guo, Jin-Xiang Chen and Quan Zhou Tags: Research Source Type: research
Photothermally Responsive siRNA Delivery by PEGylated Poly(amido amine)s for Improved Tumor Therapy
Source: Journal of Biomedical Nanotechnology - December 8, 2022 Category: Nanotechnology Authors: Xue, Hao Cai, Guoqiang Mao, Yongqing Chen, Bin Ullah, Aftab Chen, Gang Tags: research-article Source Type: research
Peptidyl Virus ‐Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells
Peptidyl virus-like nanovesicles (pVLNs) composed of bilayer membranes are assembled by the peptides and siRNA. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. The resulting gene silencing efficiency is 92% and cancer cell mortality is 96%. AbstractThe self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive...
Source: Small - November 14, 2022 Category: Nanotechnology Authors: Zixuan Wang,
Dongzhao Hao,
Yuefei Wang,
Jinwu Zhao,
Jiaxing Zhang,
Xi Rong,
Jiaojiao Zhang,
Jiwei Min,
Wei Qi,
Rongxin Su,
Mingxia He Tags: Research Article Source Type: research
Combination of polythyleneimine regulating autophagy prodrug and Mdr1 siRNA for tumor multidrug resistance
Multidrug resistance (MDR) has been restricting the efficacy of chemotherapy, which mainly include pump resistance and non-pump resistance. In order to fight overall MDR, a novel targeted gene/drug co-deliver ...
Source: Journal of Nanobiotechnology - November 11, 2022 Category: Nanotechnology Authors: Changduo Wang, Zhipeng Li, Ping Xu, Lisa Xu, Shangcong Han and Yong Sun Tags: Research Source Type: research
ASAP Magnetically Induced Brownian Motion of Iron Oxide Nanocages in Alternating Magnetic Fields and Their Application for Efficient siRNA Delivery
Nano LettersDOI: 10.1021/acs.nanolett.2c02691
Source: Nano Letters - November 8, 2022 Category: Nanotechnology Authors: Min A Kang, Justin Fang, Aloka Paragodaarachchi, Keita Kodama, Daniela Yakobashvili, Yuko Ichiyanagi, and Hiroshi Matsui Source Type: research
Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide
Although protein-based methods using cell-penetrating peptides such as TAT have been expected to provide an alternative approach to siRNA delivery, the low efficiency of endosomal escape of siRNA/protein compl...
Source: Journal of Nanobiotechnology - October 27, 2022 Category: Nanotechnology Authors: Momoko Nakamura, Kei Fujiwara and Nobuhide Doi Tags: Research Source Type: research
TfR Aptamer Enhanced Blood ‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma
Biomimetic nanocomplex (TMPsM) nanopartcles with dual blood-brain barrier (BBB) targeting capability are prepared for simultaneous accurate diagnosis and effective treatment of glioma through single intracellular transglutaminase 2-triggered self-assembly aggregation-induced emission imaging and RNAi therapy. The dual BBB targeting biomimetic outer shells endow it with enhanc ed BBB penetration, prolonged blood circulation, and ensure the delivery of inner cores into brain tumor sites for theranostic agents release. AbstractEngineering a versatile nanocomplex integrating effective penetration of the blood-brain barrier (...
Source: Small - October 6, 2022 Category: Nanotechnology Authors: Juan Su,
Zhipeng Yao,
Zixuan Chen,
Sisi Zhou,
Zhi Wang,
Hongping Xia,
Songqin Liu,
Yafeng Wu Tags: Research Article Source Type: research
Experimental Study on Antitumor Activity of Gold Nanoparticles-Assisted Delivery of PD-L1 SiRNA in Non-Small Cell Lung Cancer
Source: Journal of Biomedical Nanotechnology - September 14, 2022 Category: Nanotechnology Authors: Zhang, Yong Gu, Minwei Tags: research-article Source Type: research
Unprotonatable and ROS ‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect
An unprotonatable and reactive oxygen species-responsive nanocarrier is designed to co-deliver photodynamic reagent chlorin e6 (Ce6) and small interfering RNA (siRNA). Owing to the unprotonatable property and near infrared-activated photochemical internalization effect, the cationic nanocarrier spatially controls siRNA activity “on/off”, turning on siRNA therapy with the synergistic effect of Ce6-based photodynamic therapy in tumor tissue and turning off siRNA activity in normal tissues. AbstractAlthough small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severe...
Source: Small - September 12, 2022 Category: Nanotechnology Authors: Shaohui Deng,
Shiyin Wang,
Zecong Xiao,
Du Cheng Tags: Research Article Source Type: research
Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing
The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core –shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based ...
Source: Journal of Nanobiotechnology - August 23, 2022 Category: Nanotechnology Authors: Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu and Suxia Lin Tags: Research Source Type: research
The Application of Sensitive Nano-Confined Nanoparticle System Using siRNA Targeting Extracellular Signal-Regulated Kinase (ERK)/Mitogen-Activated Protein Kinase (MAPK) Pathway in Gastrointestinal Cancer
Source: Journal of Biomedical Nanotechnology - July 21, 2022 Category: Nanotechnology Authors: Wu, Runda Tong, Shan Kahrizi, Mohammad Saeed Zhu, Zheng Chen, Xin Tags: research-article Source Type: research
