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Total 382 results found since Jan 2013.

Inhibition of hepatitis C virus in mouse models by lipidoid nanoparticle-mediated systemic delivery of siRNA against PRK2
Publication date: Available online 22 March 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Jae-Su Moon, Seung-Hoon Lee, Song-Hee Han, Eun-Jung Kim, Hee Cho, Wooseong Lee, Mi-Kyung Kim, Tae-Eun Kim, Hyun-Ji Park, Jin-Kyu Rhee, Seong-Jun Kim, Seung-Woo Cho, Seung Hyun Han, Jong-Won Oh Host-targeting antivirals have an advantage over direct-acting antivirals in that they have a high genetic barrier to resistance. Here, we describe in vivo anti-hepatitis C virus (HCV) efficacy of a potent siRNA targeting the protein kinase C-related kinase 2 (PRK2), which phosphorylates HCV NS5B RNA-d...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 21, 2016 Category: Nanotechnology Source Type: research

A Gold Nanoparticle Platform for the Delivery of Functional TGF-β1 siRNA Into Cancer Cells
Source: Journal of Biomedical Nanotechnology - March 13, 2016 Category: Nanotechnology Authors: Wu, JindaoLiu, BinWu, HemingWu, YounongZhang, WeiZhao, ShouweiZhang, LongPan, XiongxiongGao, WenWang, XuehaoYuan, YiZhang, Yaqin Tags: Articles Source Type: research

Intracellular Trafficking and Exocytosis of a Multi-Component siRNA Nanocomplex
The objective of this study is to study post internalization trafficking of this siRNA nanocomplex and its multiple components like siRNA, protamine, and streptavidin, in HSCs. After internalization, the nanocomplex entrapped in early endosomes undergoes three possible routes including endosomal escape, exocytosis, and entrapment in lysosomes. Significant amount of siRNA dissociates form the nanocomplex to exert silencing activity. After escaping from endosomes, protamine dissociates from the nanocomplex and stays inside the cytoplasm. Golgi complex plays an important role in exocytosis of the nanocomplex. We also demonstr...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 11, 2016 Category: Nanotechnology Source Type: research

Robust neuroprotective effects of intranasally delivered iNOS siRNA encapsulated in gelatin nanoparticles in the postischemic brain
Publication date: Available online 3 March 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Il-Doo Kim, Elizabeth Sawicki, Hye-Kyung Lee, Eun-Hwa Lee, Heon Joo Park, Pyung-Lim Han, Kyekyoon (Kevin) Kim, Hyungsoo Choi, Ja-Kyeong Lee The therapeutic efficacy of intranasal iNOS siRNA delivery was investigated in the postischemic rat brain after encapsulating on in gelatin nanoparticles (GNPs; diameter 188.0±60.9 nm) cross-linked with 0.0667% glutaraldehyde (GA). Intranasally delivered GNPs were found in extracellular and intracellular compartments of many brain regions, including the olfac...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - March 4, 2016 Category: Nanotechnology Source Type: research

Theranostics: Optical Imaging and Gene Therapy with Neuroblastoma‐Targeting Polymeric Nanoparticles for Potential Theranostic Applications (Small 9/2016)
Ligand‐modified, gene‐loaded nanoparticles (NPs) are designed and prepared as a tumor‐targeting theranostic agent by I. C. Kwon, K. Y. Lee, and co‐workers. The nanoparticles offer neuroblastoma‐specific in‐vivo optical imaging, and adding a therapeutic gene cocktail into the NPs could play a critical role for gene‐therapy‐based on RNAi. On page 1201, dye‐labeled NPs are modified with rabies virus glycoprotein peptide to enhance the receptor‐mediated uptake by neuroblastoma, and an siRNA cocktail is loaded into the NPs, inducing RNA interference and significantly suppressing tumor growth in a mouse model.
Source: Small - March 1, 2016 Category: Nanotechnology Authors: Jangwook Lee, Eun Ju Jeong, Yeon Kyung Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee Tags: Inside Front Cover Source Type: research

Near Infrared-Guided Smart Nanocarriers for MicroRNA-Controlled Release of Doxorubicin/siRNA with Intracellular ATP as Fuel
ACS NanoDOI: 10.1021/acsnano.5b08145
Source: ACS Nano - February 26, 2016 Category: Nanotechnology Authors: Penghui Zhang, Chen Wang, Jingjing Zhao, Anqi Xiao, Qi Shen, Linting Li, Jianxin Li, Junfeng Zhang, Qianhao Min, Jiangning Chen, Hong-Yuan Chen and Jun-Jie Zhu Source Type: research

Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles
ACS NanoDOI: 10.1021/acsnano.5b05470
Source: ACS Nano - January 26, 2016 Category: Nanotechnology Authors: Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine Yao, Rujing Zhang, Chenglin Zhang, Yuhui Huang, Fatih M. Uckun, Jianjun Cheng, Yanfeng Zhang and Lichen Yin Source Type: research

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
Nano LettersDOI: 10.1021/acs.nanolett.5b02428
Source: Nano Letters - January 13, 2016 Category: Nanotechnology Authors: Yizhou Dong, J. Robert Dorkin, Weiheng Wang, Philip H. Chang, Matthew J. Webber, Benjamin C. Tang, Junghoon Yang, Inbal Abutbul-Ionita, Dganit Danino, Frank DeRosa, Michael Heartlein, Robert Langer and Daniel G. Anderson Source Type: research

Intranasal Brain Delivery of Cationic Nanoemulsion-Encapsulated TNFα siRNA in Prevention of Experimental Neuroinflammation
Publication date: Available online 6 January 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Sunita Yadav, Srujan K. Gandham, Riccardo Panicucci, Mansoor M. Amiji Neuroinflammation is a hallmark of acute and chronic neurodegenerative disorders. Activated microglia and secreted factors such as tumor necrosis factor-alpha (TNFα) are key mediators of neuroinflammation and may contribute to neuronal dysfunction. The main aim of this study was to evaluate the therapeutic efficacy of intranasal cationic nanoemulsions encapsulating an anti-TNFα siRNA, for potential anti-inflammatory therapy, test...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 12, 2016 Category: Nanotechnology Source Type: research

Ultrasound-Responsive Microbubbles for Sonography-guided siRNA Delivery
Publication date: Available online 28 December 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Ping Wang, Tinghui Yin, Jingguo Li, Bowen Zheng, Xiaoli Wang, Yiru Wang, Jian Zheng, Rongqin Zheng, Xintao Shuai RNA interfering is a gene therapeutic approach of great potential for cancer. However, tumor-targeted delivery of small interfering RNA (siRNA) solely based on the enhanced permeability and retention effect of nanocarriers is often insufficient. To address this challenge, siRNA encapsulated ultrasound-responsive microbubble (MB) was developed from polymeric siRNA micelles and liposo...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - December 29, 2015 Category: Nanotechnology Source Type: research