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Total 382 results found since Jan 2013.

ASAP Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA
Nano LettersDOI: 10.1021/acs.nanolett.0c04468
Source: Nano Letters - February 17, 2021 Category: Nanotechnology Authors: Chunhui Li, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, Abid Hussain, Haihua Xiao, Yuhua Weng, Yong Huang, Xiaoxia Wang, Zicai Liang, Huiqing Cao, Yongxiang Zhao, Xing-Jie Liang, Anjie Dong, and Yua Source Type: research

Novel fusion peptide ‐mediated siRNA delivery using self‐assembled nanocomplex
Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient an...
Source: Journal of Nanobiotechnology - February 12, 2021 Category: Nanotechnology Authors: Yeong Chae Ryu, Kyung Ah Kim, Byoung Choul Kim, Hui-Min David Wang and Byeong Hee Hwang Tags: Research Source Type: research

pH/ATP cascade-responsive nano-courier with efficient tumor targeting and siRNA unloading for photothermal-immunotherapy
Publication date: April 2021Source: Nano Today, Volume 37Author(s): Xian Tang, Qinglin Sheng, Chaoqun Xu, Man Li, Jingdong Rao, Xuhui Wang, Yang Long, Yuan Tao, Xuan He, Zhirong Zhang, Qin He
Source: Nano Today - February 11, 2021 Category: Nanotechnology Source Type: research

Antiangiogenic and Antitumor Therapy for Retinoblastoma with Hypoxia-Inducible Factor-1 & #945; siRNA and Celastrol Co-Delivery Nanomicelles
Source: Journal of Biomedical Nanotechnology - January 11, 2021 Category: Nanotechnology Authors: Yang, Fan Guo, Zhihua Shi, Liuqi Li, Zhanrong Zhang, Junjie Chai, Chang Li, Jingguo Tags: Research Articles Source Type: research

Photo ‐Enhanced CRISPR/Cas9 System Enables Robust PD‐L1 Gene Disruption in Cancer Cells and Cancer Stem‐Like Cells for Efficient Cancer Immunotherapy
This study provides an alternative strategy to block the PD‐1/PD‐L1 pathway for efficacious immune checkpoint therapy.
Source: Small - December 2, 2020 Category: Nanotechnology Authors: Liang Zhao, Yingli Luo, Qiaoyi Huang, Ziyang Cao, Xianzhu Yang Tags: Full Paper Source Type: research

Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model
Publication date: Available online 28 November 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Christian Macks, DaUn Jeong, Jeoung Soo Lee
Source: Nanomedicine: Nanotechnology, Biology and Medicine - November 29, 2020 Category: Nanotechnology Source Type: research

Targeted Combination of Antioxidative and Anti ‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform
A multifunctional dendrimer nanoplatform is developed to have entrapped gold nanoparticles within dendrimer interiors, and covalently linked PEGylated alpha ‐tocopheryl succinate, PEGylated folic acid, and 1,3‐propane sultone on dendrimer peripheries. The designed nanoplatform enables co‐delivery of drug/gene to macrophage cells, effectively scavenging reactive oxygen species and inhibiting tumor necrosis factor‐α expression for combined antiox idative and anti‐inflammatory therapy of rheumatoid arthritis. AbstractAbundant reactive oxygen species and tumor necrosis factor ‐α (TNF‐α) cytokine supply of M1...
Source: Small - November 17, 2020 Category: Nanotechnology Authors: Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen, Xiangyang Shi Tags: Full Paper Source Type: research

Quantitative Assessment of Endosomal Escape of Various Endocytosed Polymer ‐Encapsulated Molecular Cargos upon Photothermal Heating
A methodology is reported to monitor the dynamic process of 43 fluorescent cargos released from the polymeric capsules and the lysosomes where capsules are trapped, and their spread in the cytosol upon short laser irradiation. Intracellular spread cannot be described by free diffusion, but is determined by interaction of the molecular cargo with intracellular components. AbstractEncapsulated molecular cargos are efficiently endocytosed by cells. For cytosolic delivery, understanding the dynamic process of cargos release from the carrier vehicles used for encapsulation and the lysosomes where the carrier vehicles are trappe...
Source: Small - October 27, 2020 Category: Nanotechnology Authors: Nico Brkovic, Li Zhang, Jan N. Peters, Stephan Kleine ‐Doepke, Wolfgang J. Parak, Dingcheng Zhu Tags: Full Paper Source Type: research

Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional Delta-5-Desaturase siRNA nanoparticle for breast cancer therapy
Publication date: Available online 12 September 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Harshit Shah, Lizhi Pang, Hongzhi Wang, Dan Shu, Steven Y. Qian, Venkatachalem Sathish
Source: Nanomedicine: Nanotechnology, Biology and Medicine - September 14, 2020 Category: Nanotechnology Source Type: research

Carrier-free nanoassembly of doxorubicin prodrug and siRNA for combinationally inducing immunogenic cell death and reversing immunosuppression
Publication date: December 2020Source: Nano Today, Volume 35Author(s): Senbiao Chen, Dongdong Li, Xiaojiao Du, Xinyu He, Mengwen Huang, Yang Wang, Xianzhu Yang, Jun Wang
Source: Nano Today - July 15, 2020 Category: Nanotechnology Source Type: research