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Specialty: Nanotechnology
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Total 382 results found since Jan 2013.
Inhibiting HER3 Hyperphosphorylation in HER2 ‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells
A multimodal theranostic nanoplatform to treat breast cancer overexpressing the human epidermal growth factor receptors 2 (HER2) and 3 (HER3) is developed, and consisting of doxorubicin-loaded branched gold nanoshells functionalized with a small interfering RNA against HER3 and the HER2-specific antibody Trastuzumab able to simultaneously combine chemo- and photothermal, RNA silencing and immuno-therapies overcoming chemoresistance and reducing tumor size in vivo. AbstractTreatment failure in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) is associated mainly to the upregulation of human epid...
Source: Small - August 26, 2023 Category: Nanotechnology Authors: Eva Villar ‐Alvarez,
Irene Golán‐Cancela,
Alberto Pardo,
Brenda Velasco,
Javier Fernández‐Vega,
Adriana Cambón,
Abeer Al‐Modlej,
Antonio Topete,
Silvia Barbosa,
José A. Costoya,
Pablo Taboada Tags: Research Article Source Type: research
M2 Macrophage Membrane ‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation (Small 33/2023)
Targeted Delivery SystemsJun Tan, You Lang Zhou, and co-workers construct successfully an M2M@PLGA/COX-siRNA delivery system and measure its targeting properties and therapeutic effects on a rat model of flexor digitorum longus (FDL) tendon injury combined with rotator cuff injury. Treatment outcomes indicate that the M2M@PLGA delivery system could provide an effective biological strategy for preventing multiple tendon adhesions. More details can be found in article number2300326.
Source: Small - August 17, 2023 Category: Nanotechnology Authors: Jie Sun,
Fei Ju,
Jing Jin,
Hao Liang Wang,
Zhi Jie Li,
Yu Cheng Sun,
Qing Zhong Chen,
Qian Qian Yang,
Jun Tan,
You Lang Zhou Tags: Inside Back Cover Source Type: research
Massively Parallel High ‐Throughput Single‐Cell Patterning and Large Biomolecular Delivery in Mammalian Cells Using Light Pulses
High-throughput single-cell patterning is presented for massively parallel optoporation-mediated intracellular delivery of small to very large cargo such as PI dye (668 Da), Dextran (3000 MW), siRNA (20–24 bp), and enzyme (464 kDa), using a titanium micro-dish device. The approach is compact, robust, easy to use and potentially applicable for single-cell therapy and diagnostics. AbstractThe recent advancements of single-cell analysis have significantly enhanced the ability to understand cellular physiology when compared to bulk cellular analysis. Here a massively parallel single-cell patterning and very large biomole...
Source: Small - August 7, 2023 Category: Nanotechnology Authors: Gayathri R,
Srabani Kar,
Moeto Nagai,
Pallab Sinha Mahapatra,
Tuhin Subhra Santra Tags: Research Article Source Type: research
Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo,
Cristian Salvador,
Patrizia Andreozzi,
Vanessa Gomez ‐Vallejo,
Gabriela Romero,
Damien Dupin,
Jordi Llop,
Sergio E. Moya Tags: Research Article Source Type: research
Carbon Dots with Guanidinium and Amino Acid Functional Groups for Targeted Small Interfering RNA Delivery toward Tumor Gene Therapy (Small 31/2023)
This study provides a versatile strategy for tumor-targeted gene therapy.
Source: Small - August 3, 2023 Category: Nanotechnology Authors: Huimin Xu,
Jianqiao Chang,
Hao Wu,
Haoyu Wang,
Wenjing Xie,
Yunchao Li,
Xiaohong Li,
Yang Zhang,
Louzhen Fan Tags: Frontispiece Source Type: research
Enhanced anticancer activity of siRNA and drug codelivered by anionic biopolymer: overcoming electrostatic repulsion
Nanomedicine, Ahead of Print.
Source: Future Medicine: Nanomedicine - July 28, 2023 Category: Nanotechnology Authors: Lipika Ray Sutapa Ray Source Type: research
A Bayesian Implementation of Quality-by-Design for the Development of Cationic Nano-Lipid for siRNA Transfection
In this study, a Bayesian approach including variable selection, parameter estimation and model quality assessment is proposed and assessed using a real case study devoted to the development of a Cationic Nano-Lipid Structures for siRNA Transfection. Two original model structures are also included to describe both binary and percentage response variables. The results confirm the practical relevance and applicability of the Bayesian implementation of the QbD analysis.
Source: IEE Transactions on NanoBioscience - June 30, 2023 Category: Nanotechnology Source Type: research
Simultaneous Delivery of Doxorubicin and EZH2 ‐Targeting siRNA by Vortex Magnetic Nanorods Synergistically Improved Anti‐Tumor Efficacy in Triple‐Negative Breast Cancer
A novel nanomedicine is synthesized based on Fe3O4 vortex nanorods loaded with doxorubicin (DOX) and EZH2 siRNAs and coated with a macrophage membrane. It shows a preferential tumor enrichment profile, thus leading to highly efficient drug delivery at the tumor site. Combining chemotherapy and gene therapy exhibits synergistic antitumor activity in a preclinical TNBC model. AbstractTriple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3O4 vortex ...
Source: Small - June 28, 2023 Category: Nanotechnology Authors: Yunshu Lu,
Fenfen Gu,
Yuwei Ma,
Ruonan Li,
Yi Luo,
Xianhong Da,
Lan Jiang,
Xiang Li,
Yan Liu Tags: Research Article Source Type: research
Ionizable Lipid with Supramolecular Chemistry Features for RNA Delivery In Vivo
In this report, supramolecular chemistry concepts are incorporated into the rational design of a new ionizable lipid, C3-K2-E14, for systemic administration. This lipid incorporates a cone-shaped structure intended to facilitate cell bilayer disruption, and three tertiary amines to improve RNA binding. Additionally, hydroxyl and amide motifs are incorporated to further enhance RNA binding and improve LNP stability. Optimization of messenger RNA (mRNA) and small interfering RNA (siRNA) formulation conditions and lipid ratios produce LNPs with favorable diameter (<150 nm), polydispersity index (<0.15), and RNA encaps...
Source: Small - June 14, 2023 Category: Nanotechnology Authors: Alanna M. Manning,
Grayson Tilstra,
Aniqa B. Khan,
Julien Couture ‐Senécal,
Yan Ming Anson Lau,
Janice Pang,
Amina A. Abow,
Clinton S. Robbins,
Omar F. Khan Tags: Research Article Source Type: research
Precision Therapy of Recurrent Breast Cancer through Targeting Different Malignant Tumor Cells with a HER2/CD44‐Targeted Hydrogel Nanobot
Schematic illustration of the preparation of a HER2/CD44-targeted hydrogel nanobot (ALPR) by embedding the positively charged bio-responsive, liposome-encapsulated nanoparticles (LPR) formed by cationic liposome DOTAP/DOPE, survivin siRNA, andD-(KLAKLAK)2GGR16 (KLA-R16) into negatively charged Herceptin/hyaluronic acid cross-linked nanohydrogels (Herceptin-HA). AbstractHeterogeneity and drug resistance of tumor cells are the leading causes of incurability and poor survival for patients with recurrent breast cancer. In order to accurately deliver the biological anticancer drugs to different subtypes of malignant tumor cells...
Source: Small - May 8, 2023 Category: Nanotechnology Authors: Juan Chen,
Jinjin Li,
Xiaolu Sun,
Huixia Lu,
Kuai Liu,
Zhenbo Li,
Jianyue Guan,
Huiling Song,
Wei Wei,
Yanhong Ge,
Qiong Fan,
Wei Bao,
Buyong Ma,
Zixiu Du Tags: Research Article Source Type: research
Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual ‐Signal Transform‐Based Selenium Antioxidant
Schematic representation of the selenium-based antioxidant defense nanosystem Se@BDP-DOH NPs for photoacoustic monitoring of spinal cord injury. AbstractSpinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well as monitoring and assessing the recovery from SCI are critical for the emergency treatment of SCI. Herein, an emergency treatment strategy is developed for SCI based on the selenium (Se) matrix antioxidant system to effectively inhibit ...
Source: Small - May 2, 2023 Category: Nanotechnology Authors: Zhisheng Ji,
Judun Zheng,
Yanming Ma,
Hongyi Lei,
Weiqiang Lin,
Jialin Huang,
Hua Yang,
Guowei Zhang,
Bin Li,
Bowen Shu,
Xianjin Du,
Jian Zhang,
Hongsheng Lin,
Yuhui Liao Tags: Research Article Source Type: research
M2 Macrophage Membrane ‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation
An M2M@PLGA/COX-siRNA delivery system is successfully constructed and measured its targeting properties and therapeutic effects on a rat model of flexor digitorum longus tendon injury combined with rotator cuff injury. These findings indicate that the M2M@PLGA delivery system can provide an effective biological strategy for preventing m ultiple tendon adhesions. AbstractTendon adhesion is the most common outcome of tendon or tendon-to-bone healing after injury. Our group developed a hydrogel-nanoparticle sustained-release system previously to inhibit cyclooxygenases (COXs) expression and consequently prevent tendon a...
Source: Small - April 5, 2023 Category: Nanotechnology Authors: Jie Sun,
Fei Ju,
Jing Jin,
Hao Liang Wang,
Zhi Jie Li,
Yu Cheng Sun,
Qing Zhong Chen,
Qian Qian Yang,
Jun Tan,
You Lang Zhou Tags: Research Article Source Type: research
ASAP Light-Activated siRNA Endosomal Release (LASER) by Porphyrin Lipid Nanoparticles
ACS NanoDOI: 10.1021/acsnano.2c10936
Source: ACS Nano - February 28, 2023 Category: Nanotechnology Authors: Yulin Mo, Miffy H. Y. Cheng, Andrew D ’Elia, Katie Doran, Lili Ding, Juan Chen, Pieter R. Cullis, and Gang Zheng Source Type: research
Carbon Dots with Guanidinium and Amino Acid Functional Groups for Targeted Small Interfering RNA Delivery toward Tumor Gene Therapy
Large amino acid mimicking carbon dots with guanidinium functionalization (LAAM GUA-CDs) can be prepared to carry small interfering RNA by multiple hydrogen bonds and target to tumor tissues specifically through LAT1 receptor. After loading siBcl-2 as a therapeutic agent, LAAM GUA-CDs/siBcl-2 bring about superior antitumor effects without side effects during the gene therapy. AbstractSmall interfering RNA (siRNA)-based gene therapy represents a promising strategy for tumor treatment. Novel gene vectors that can achieve targeted delivery of siRNA to the tumor cells without causing any side effects are urgently needed. To th...
Source: Small - February 25, 2023 Category: Nanotechnology Authors: Huimin Xu,
Jianqiao Chang,
Hao Wu,
Haoyu Wang,
Wenjing Xie,
Yunchao Li,
Xiaohong Li,
Yang Zhang,
Louzhen Fan Tags: Research Article Source Type: research
