Amphiphilic poly( α)glutamate polymeric micelles for systemic administration of siRNA to tumors

RNAi therapeutics carried a great promise to the area of personalized medicine: the ability to target “undruggable” oncogenic pathways. Nevertheless, their efficient tumor targeting via systemic administration had not been resolved yet. Amphiphilic alkylated poly(α)glutamate amine (APA) can serve as a cationic carrier to the negatively-charged oligonucleotides. APA polymers complexed with siRNA to form round-shaped, homogenous and reproducible nano-sized polyplexes bearing ~50nm size and slightly negative charge.

Source: Nanomedicine : Nanotechnology, Biology, and Medicine - November 7, 2017 Category: Nanotechnology Authors: Adva Krivitsky, Dina Polyak, Anna Scomparin, Shay Eliyahu, Paula Ofek, Galia Tiram, Hagar Kalinski, Sharon Avkin-Nachum, Nat àlia Feiner Gracia, Lorenzo Albertazzi, Ronit Satchi-Fainaro Source Type: research