Lobelia trigona Roxb-based nanomedicine with enhanced biological applications: in vitro and in vivo approach
This study shows and suggests that the previously unreported LTAgNPs could be used as a nanomedicine with significant biological applications. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Amino-functionalised mesoporous silica microspheres for immobilisation of Candida antarctica lipase B – application towards greener production of 2,5-furandicarboxylic acid
In the present study, amino-functionalised mesoporous silica microspheres were utilised as support for the covalent immobilisation of Candida antarctica lipase B (CaLB) for the subsequent production of 2,5-furandicarboxylic acid (FDCA) from 2,5-diformylfuran (DFF). Under the optimised operating conditions of pH 6.5, particle/enzyme ratio of 1.25:1.0 and glutaraldehyde concentration of 4 mM, a maximum CaLB immobilisation yield of 82.4% on silica microspheres was obtained in 12.25 h. The immobilised CaLB was used for the synthesis of alkyl esters, which were utilised along with hydrogen peroxide for FDCA synthe...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Assessment of acaricidal activity of nanoscale ZnO encapsulated piperine formulation against Rhipicephalus microplus
This study aims to synthesise and evaluate the acaricidal activity of nanoscale zinc oxide piperine formulation (NZPF) against Rhipicephalus microplus ticks. NZPF was prepared by using zinc oxide nanoparticles (ZnONPs) and piperine by employing encapsulation technique; characterised by UV spectroscopy, Fourier transformed infrared analysis, X-ray diffraction, dynamic light scattering, zetapotential and scanning electron microscopy. Acaricidal activity of the NZPF on R. microplus was evaluated using larval packet test (LPT) and adult immersion test (AIT). LPT against R. microplus larvae showed an LC50 at 1 mg/l for N...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Solvothermal-assisted green synthesis of hybrid Chi-Fe3O4 nanocomposites: a potential antibacterial and antibiofilm material
In conclusion, this present study shows the green synthesis of Chi-Fe3O4 nanocomposite and evaluation of its antibacterial and antibiofilm potential, proving its significance in medical and biological applications (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Green synthesis of AgCl/Ag3PO4 nanoparticle using cyanobacteria and assessment of its antibacterial, colorimetric detection of heavy metals and antioxidant properties
In this study, the extract of two strains of cyanobacteria was used for the synthesis of silver nanoparticles (NPs). UV–vis spectroscopy, X-ray diffraction, dynamic light scattering and field emission scanning electron microscopy (FESEM) analyses were carried out to characterise the NPs. The antioxidant activity and heavy metal detection properties were investigated; moreover, their minimum inhibitory concentration and minimum bactericidal concentration against the multi-drug resistant bacteria were determined. The most abundant materials in these extracts were carbohydrates, so the biosynthesis of NPs using exopoly...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Development of bioactive zirconium–tin alloy by combination of micropores formation and apatite nuclei deposition
In this study, the authors developed the method to achieve apatite-forming ability in Zr alloy within 1 day in SBF by a combination with apatite nuclei that promote apatite formation in SBF. First, Zr–Sn alloy was soaked in concentrated sulphuric acid, and pores in micro-level were formed on the surface of Zr–Sn alloy. To attain apatite forming ability in Zr–Sn alloy, second, apatite nuclei were formed in the micropores. To evaluate apatite-forming ability, thus-obtained Zr–Sn alloy with apatite nuclei was soaked in SBF; hydroxyapatite formation was observed on the whole surface of the Zr–...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
CdO nanoparticles, c-MWCNT nanoparticles and CdO nanoparticles/c-MWCNT nanocomposite fibres: in vitro assessment of anti-proliferative and apoptotic studies in HeLa cancer cell line
In conclusion, based on our observations, CdO NPs/c-MWCNT hybrid based system can be further used for the development of efficient drug delivery and therapeutic systems. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Improvement of hydroxyapatite formation ability of titanium-based alloys by combination of acid etching and apatite nuclei precipitation
The authors aimed to improve hydroxyapatite formation ability of Ti6Al4V, Ti-15Mo-5Zr-3Al alloy, Ti-12Ta-9Nb-6Zr-3V-O alloy (Gummetal®) and commercially pure Ti (cpTi) mesh by a combination of acid etching and apatite nuclei precipitation. Surfaces of specimens were etched with H2SO4 for pores formation on the specimens. Thus-etched specimens were soaked in an alkalinised simulated body fluid (SBF), which was adjusted at higher pH than that of conventional SBF and this solution was subsequently heated. By this treatment, apatite nuclei were precipitated in the pores of the specimens. By a soak in the conventional SBF ...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Zinc oxide nanoparticles augment CD4, CD8, and GLUT-4 expression and restrict inflammation response in streptozotocin-induced diabetic rats
This study evaluated the biochemical, molecular, and histopathological mechanisms involved in the hypoglycaemic effect of zinc oxide nanoparticles (ZnONPs) in experimental diabetic rats. ZnONPs were prepared by the sol–gel method and characterised by scanning and transmission electron microscopy (SEM and TEM). To explore the possible hypoglycaemic and antioxidant effect of ZnONPs, rats were grouped as follows: control group, ZnONPs treated group, diabetic group, and diabetic + ZnONPs group. Upon treatment with ZnONPs, a significant alteration in the activities of superoxide dismutase, glutathione perox...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Impartation of hydroxyapatite formation ability to ultra-high molecular weight polyethylene by deposition of apatite nuclei
The authors aimed to impart hydroxyapatite formation ability to ultra-high molecular weight polyethylene (UHMWPE) by deposition of apatite nuclei (ApN) by the following two methods. The first method was electrophoretic deposition (EPD). A porous UHMWPE was placed between electrodes in the ApN-dispersed ethanol and constant voltage was applied. By this treatment, the ApN were migrated from anode-side surface to the cathode one through the pores by an electric field in the pores of the UHMWPE and deposited inside the pores. The second method was direct precipitation (DP) of the ApN. A porous UHMWPE was soaked in a simulated ...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Impartation of apatite-forming ability to chitosan nanofibres by using apatite nuclei
In this study, the authors prepared three types of apatite nuclei by changing the reaction time aimed to optimise their crystallinity and fabricated their composites with chitosan nanofibre. In order to evaluate the bioactivity in vitro, the authors tested apatite-forming ability in simulated body fluid. As a result, the materials showed enough apatite-forming ability in a short time by mixing chitosan nanofibre and apatite nuclei with extremely low crystallinity and their high reactivity in simulated body fluid. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Protein adsorption on spark plasma sintered 2d-, 3d- and lamellar type mesoporous silicate compacts
The preparation of lamellar type mesoporous silica (MPS) compact through the spark plasma sintering (SPS) and the adsorption/desorption of protein onto MPS compact are reported to be compared with those onto 2d-hexagonal and 3d-cubic type MPS compacts. A lamellar-type MPS powder (MPS-la) was prepared using triblock copolymer, PEO5PPO68PEO5, and was compacted in a carbon die and heated at 500°C for 5 min under uniaxial pressure. The products are referred to as MPS-la-500. The MPS compacts keep the lamellar type mesoporous configuration. The adsorbed amount of protein onto MPS-la-500 was 100 mg/g, while th...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Isolation, process optimisation and characterisation of the protein from the de-oiled cake flour of Madhuca latifolia
This work reports the isolation of the protein from the flour of an underutilised agro waste, a de-oiled cake of Madhuca latifolia using the bis (2-ethylehexyl) sodium sulfosuccinate salt reverse micelle and the characterisation of the protein through various techniques. The experimental conditions for the extraction were optimised using Box–Behnken design. The highest yield of the protein was achieved when the extraction parameters, i.e. KCl concentration, KCl amount, and pH of the medium, were 0.5 M, 1.25 ml, and 9.02, respectively. The experimental yield (75.56%) obtained under the optimised conditi...
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Silk-based microcarriers: current developments and future perspectives
In this study, the physicochemical and biological properties of these biomaterials, as well as the recent methodologies for their processing and for cell culture, are discussed. The potential biomedical applications are also addressed. In addition, an analysis of the future perspectives is presented, where the potential of innovative silk-based MCs processing technologies is highlighted. (Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
Guest Editorial: Selected extended papers from the International conference of the 19th Asian BioCeramic Symposium
(Source: IET Nanobiotechnology)
Source: IET Nanobiotechnology - October 30, 2020 Category: Nanotechnology Source Type: research
