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Nutrition: Herbs

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Total 217 results found since Jan 2013.

Ephedrine induced Thioredoxin-1 expression through β-adrenergic receptors/Cyclic AMP/protein kinase A/dopamine- and Cyclic AMP-regulated phosphoprotein signaling pathway.
In this study, we found that Eph induced Trx-1 expression, which was inhibited by propranolol (β-adrenergic receptors inhibitor), but not by phenoxybenzamine (α-adrenergic receptors inhibitor) in rat pheochromocytoma PC12 cells. Moreover, the increase of Trx-1 expression was inhibited by SQ22536 (adenylyl cyclase inhibitor) and H-89 (protein kinase A inhibitor). Interestingly, the effect of Eph on dopamine- and Cyclic AMP-regulated phosphoprotein (DARPP-32) was similar to Trx-1. Thus, the relationship between Trx-1 and DARPP-32 was further studied. The DARPP-32 siRNA significantly reduced Trx-1 expression, but Trx-1 siRN...
Source: Cellular Signalling - February 14, 2013 Category: Cytology Authors: Jia JJ, Zeng XS, Li Y, Ma S, Bai J Tags: Cell Signal Source Type: research

Salidroside reduces cold-induced mucin production by inhibiting TRPM8 activation.
Abstract Salidroside is an effective component of the traditional Chinese herb, Rhodiola rosea, that is known to have the ability to protect individuals from cold attacks. In the present study, we investigated the effects of salidroside on respiratory epithelial cells exposed to cold temperatures. We wished to determine whether salidroside exerts any effect on cold-induced mucin (MUC) production and the possible mechanisms involved in this process. We incubated HBE16 cells with salidroside, exposed them to a cold stimulus (18˚C), and assayed the following endpoints: MUC production (the expression of MUC5AC), conc...
Source: International Journal of Molecular Medicine - July 5, 2013 Category: Molecular Biology Authors: Li Q, Zhou XD, Kolosov VP, Perelman JM Tags: Int J Mol Med Source Type: research

Purified vitexin compound 1 inhibits growth and angiogenesis through activation of FOXO3a by inactivation of Akt in hepatocellular carcinoma.
Abstract Vitexins, isolated from the seeds of the Chinese herb Vitex negundo, is known to exert antitumor activity in cancer xenograft models and cell lines. The aim of the current study was to examine whether the Akt/forkhead box protein O3a (FOXO3a) pathway mediates the biological effects of purified vitexin compound 1 (VB-1) in hepatocellular carcinoma (HCC) cells. The effect of VB-1 on the viability of the HCC cell lines HepG2, Hep3B, Huh-7 and the human embryonic liver cells L-02 was investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Growth inhibition was assess...
Source: International Journal of Molecular Medicine - December 12, 2013 Category: Molecular Biology Authors: Wang J, Zheng X, Zeng G, Zhou Y, Yuan H Tags: Int J Mol Med Source Type: research

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research

Involvement of C/EBPβ in monocytic differentiation of acute myeloid leukemia cells induced by LW-218, a new synthesized flavonoid.
In this study, we found that LW-218, a new synthesized flavonoid, inhibited proliferation and induced differentiation of acute myeloid leukemia cells. The IC50s of LW-218 in HL-60, U937, K562, and NB4 cell lines were all less than 5 μM, suggesting greater capacity than compounds we have reported. LW-218 induced differentiation effects including morphologic changes, NBT reduction, and both of CD11b and CD14 expression. Results of western blots and siRNA transfection revealed that LW-218 increased the LAP/LIP ratio of C/EBPβ which regulated monocytic differentiation of leukemia cells. Meanwhile, these differentiation eff...
Source: Neoplasma - August 23, 2014 Category: Cancer & Oncology Authors: Wang Q, Hui H, Yang H, Li H, Gao Y, Li Z, Guo Q, Lu N Tags: Neoplasma Source Type: research

NBM-T-BMX-OS01, an Osthole Derivative, Sensitizes Human Lung Cancer A549 Cells to Cisplatin through AMPK-Dependent Inhibition of ERK and Akt Pathway
Conclusion: Taken together, this study provides that BMX might modulate cisplatin resistance through AMPK-ERK and AMPK-Akt pathways. These results also support the role of BMX as a potential drug candidate for use in combination with cisplatin in the treatment of human lung cancer.Cell Physiol Biochem 2015;36:893-906
Source: Cellular Physiology and Biochemistry - June 9, 2015 Category: Cytology Source Type: research

Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway
Conclusion: The results suggested that berberine modulated the sensitivity of cisplatin through miR-93/PTEN/AKT signaling pathway in the ovarian cancer cells.Cell Physiol Biochem 2015;36:956-965
Source: Cellular Physiology and Biochemistry - June 16, 2015 Category: Cytology Source Type: research

Neuroprotection of Sanhua Decoction against Focal Cerebral Ischemia/Reperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4.
In conclusion, SHD exerted neuroprotection against focal cerebral I/R injury in rats mainly through a mechanism targeting AQP4. PMID: 26089944 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - June 21, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt/Nrf2/HO-1 and calcium signalling pathways
Publication date: October 2015 Source:Journal of Functional Foods, Volume 18, Part A Author(s): Si Wan Lei, Guozhen Cui, George Pak Heng Leung, Sharon Chui Wah Luk, Maggie Pui Man Hoi, Liang Wang, Gail B. Mahady, Simon Ming Yuen Lee Icaritin, a prenylflavonoid isolated from Herbal Epimedii, is well known for its osteoplastic and anti-tumour activities. Here, we examined the cardioprotective actions of icaritin on cardiac H9c2 cells under oxidative stress conditions induced by treatment with tert-butylhydroperoxide (t-BHP). Icaritin at a concentration range between 1 and 4 µM effectively increased cell viabilit...
Source: Journal of Functional Foods - July 30, 2015 Category: Nutrition Source Type: research

Geniposide alleviates inflammation by suppressing MeCP2 in mice with carbon tetrachloride-induced acute liver injury and LPS-treated THP-1 cells.
In this study, GP significantly attenuated inflammation in acute liver injury (ALI) mice model and in lipopolysaccharide (LPS)-induced THP-1 cells. It was demonstrated that GP obviously decreased the expression of Methyl-CpG binding protein 2 (MeCP2) in vivo and in vitro. Knockdown of MeCP2 with siRNA suppressed the expressions of IL-6 and TNF-α, while over-expression of MeCP2 had a proinflammatory effect on the expression of IL-6 and TNF-α in LPS-induced THP-1 cells. Mechanistically, it was indicated that GP had anti-inflammatory effects at least in part, through suppressing MeCP2. Interestingly, GP could attenuate expr...
Source: International Immunopharmacology - September 11, 2015 Category: Allergy & Immunology Authors: Ma TT, Li XF, Li WX, Yang Y, Huang C, Meng XM, Zhang L, Li J Tags: Int Immunopharmacol Source Type: research

Esculentoside A Attenuates Allergic Airway Inflammation via Activation of the Nrf-2 Pathway
Conclusions: This is the first study to illustrate that EsA acts as a novel Nrf-2 activator, which modulates the oxidative stress pathway to improve lung injury and ameliorate the development of airway inflammation.Int Arch Allergy Immunol 2015;167:280-290
Source: International Archives of Allergy and Immunology - October 24, 2015 Category: Allergy & Immunology Source Type: research

Berberine Hydrochloride Protects C2C12 Myoblast Cells Against Oxidative Stress ‐Induced Damage via Induction of Nrf‐2‐Mediated HO‐1 Expression
ABSTRACT The aim of the present study was to evaluate the effects of berberine hydrochloride (BBH), an isoquinoline alkaloid that can be isolated from a variety of herbs, on hydrogen peroxide (H2O2)‐induced oxidative stress in C2C12 myoblasts and to investigate the molecular mechanisms involved in this process, especially the expression of the Nrf2/HO‐1 pathway. BBH preconditioning attenuated H2O2‐induced growth inhibition and DNA damage as well as apoptosis in C2C12 cells via suppression of the accumulation of intracellular reactive oxygen species (ROS). Treatment with BBHride alone effectively upregulated th...
Source: Drug Development Research - July 31, 2016 Category: Drugs & Pharmacology Authors: Yung Hyun Choi Tags: Research Article Source Type: research

SH003 selectively induces p73 ‑dependent apoptosis in triple‑negative breast cancer cells.
SH003 selectively induces p73‑dependent apoptosis in triple‑negative breast cancer cells. Mol Med Rep. 2016 Sep 6; Authors: Choi EK, Kim SM, Hong SW, Moon JH, Shin JS, Kim JH, Hwang IY, Jung SA, Lee DH, Lee EY, Lee S, Kim H, Kim D, Kim YS, Choi YK, Kim HI, Choi HS, Cho SG, Kim JE, Kim KP, Hong YS, Lee WK, Lee JS, Kim TW, Ko SG, Jin DH Abstract Triple-negative breast cancer (TNBC) is a breast cancer subtype that has an aggressive phenotype, is highly metastatic, has limited treatment options and is associated with a poor prognosis. In addition, metastatic TNBC has no preferred standard chemotherapy ...
Source: Molecular Medicine Reports - September 10, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
In conclusion, our data indicated that shikonin treatment induced necroptosis and autophagy in NSCLC cells. In addition, inhibition of shikonin-induced autophagy enhanced necroptosis, suggesting that shikonin could be a novel therapeutic strategy against NSCLC.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Hwang, K. E., Jeong, E. T., Kim, H. R. Tags: 11.1 Lung Cancer Source Type: research

Differential regulation of baicalin and scutellarin on AMPK and Akt in promoting adipose cell glucose disposal
In conclusion, baicalin and scutellarin, though structurally similar, promoted glucose disposal in adipocytes by differential regulation on AMPK and Akt activity. Our data provide insight that multicomponent herbal medicines may act synergistically and cooperatively on multiple targets. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 26, 2016 Category: Molecular Biology Source Type: research