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Total 217 results found since Jan 2013.

Tanshinone IIA inhibits lipopolysacharide-induced MUC1 overexpression in alveolar epithelial cells.
In this study, we investigated the effects of TIIA on lipopolysaccharide (LPS)-induced acute lung inflammation, as well as its relationship to Muc1 expression in mouse lung and MUC1 in human alveolar epithelial cells. TIIA pretreatment significantly inhibited LPS-induced pulmonary inflammation in both Muc1 wild type (Muc1(+/+)) and knockout (Muc1(-/-)) mice, as manifested by reduced neutrophils infiltration, and reduced TNF-α and KC levels in bronchoalveolar lavage (BAL) fluid. The inhibitory effects of TIIA on airway inflammation were associated with reduced expression of Muc1 in Muc1(+/+) mouse lung. Moreover, pretreatm...
Source: American Journal of Physiology. Cell Physiology - October 23, 2013 Category: Cytology Authors: Zhang K, Wang J, Jiang H, Xu X, Wang S, Zhang C, Li Z, Gong X, Lu W Tags: Am J Physiol Cell Physiol Source Type: research

Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells
In this study, we investigated the effects of TIIA on LPS-induced acute lung inflammation, as well as its relationship to Muc1 expression in mouse lung and MUC1 in human alveolar epithelial cells. TIIA pretreatment significantly inhibited LPS-induced pulmonary inflammation in both Muc1 wild-type (Muc1+/+) and knockout (Muc1–/–) mice, as manifested by reduced neutrophil infiltration and reduced TNF-α and keratinocyte chemoattractant levels in bronchoalveolar lavage fluid. The inhibitory effects of TIIA on airway inflammation were associated with reduced expression of Muc1 in Muc1+/+ mouse lung. Moreover, p...
Source: AJP: Cell Physiology - January 1, 2014 Category: Cytology Authors: Zhang, K., Wang, J., Jiang, H., Xu, X., Wang, S., Zhang, C., Li, Z., Gong, X., Lu, W. Tags: ARTICLES Source Type: research

Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
This study aimed to investigate the effect of SalB on acute ethanol-induced hepatic injury in rats and to explore the role of SIRT1 in this process. The results showed that pretreatment with SalB significantly reduced ethanol-induced elevation in aminotransferase activities, decreased hepatotoxic cytokine levels such as Interleukin-6 (IL-6), and increased the antioxidant enzyme activity. Moreover, SalB pretreatment reversed the increase in NF-κB, cleaved caspase-3 and decrease in B-cell lymphoma-extra large (Bcl-xL) caused by ethanol exposure. Importantly, SalB pretreatment significantly increased the expression of SIRT1,...
Source: Toxicology Letters - April 21, 2014 Category: Toxicology Authors: Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J Tags: Toxicol Lett Source Type: research

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
Abstract Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, could be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX), an oncoprotein from hepatitis B virus. When ASK was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. ASK induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from ASK-induced apoptosis, indicating that N...
Source: European Journal of Pharmacology - April 24, 2014 Category: Drugs & Pharmacology Authors: Moon J, Koh SS, Malilas W, Cho IR, Kaewpiboon C, Kaowinn S, Lee K, Jhun BH, Choi YW, Chung YH Tags: Eur J Pharmacol Source Type: research

Anti-cancer activity of Ginger (Zingiber officinale) leaf through the expression of activating transcription factor 3 in human colorectal cancer cells
Conclusions: These findings suggest that the reduction of cell viability and apoptosis by GL may be a result of ATF3 promoter activation and subsequent increase of ATF3 expression through ERK1/2 activation in human colorectal cancer cells.
Source: BMC Complementary and Alternative Medicine - October 23, 2014 Category: Complementary Medicine Authors: Gwang Hun ParkJae Ho ParkHun Min SongHyun Ji EoMi Kyoung KimJin Wook LeeMan Hyo LeeKiu-Hyung ChoJeong Rak LeeHyeon Je ChoJin Boo Jeong Source Type: research

Ganoderma lucidum inhibits proliferation of human ovarian cancer cells by suppressing VEGF expression and up-regulating the expression of connexin 43
Conclusions: G. lucidum inhibits ovarian cancer by down-regulating the expression of VEGF and up-regulating the downstream Cx43 expression. G. lucidum may be a promising therapeutic agent for the treatment of ovarian cancer.
Source: BMC Complementary and Alternative Medicine - November 5, 2014 Category: Complementary Medicine Authors: Shuyan DaiJingjing LiuXiaofei SunNing Wang Source Type: research

Abstract 1255: The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells
Conclusion: Rosemary induces ER stress-mediated apoptotic cell death in prostate cancer cell lines, 22Rv1and LNCaP cells, leading to disruption of AR expression. Our data suggests that this Mediterranean dietary phytochemical possess strong anticancer activity and should be evaluated further as potential chemopreventive and/or chemotherapeutic agent for controlling prostate cancer. Citation Format: Sakina M. Petiwala, Saba Berhe, Gongbo Li, Angela G. Puthenveetil, Larisa Nonn, Jeremy J. Johnson. The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells. [...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petiwala, S. M., Berhe, S., Li, G., Puthenveetil, A. G., Nonn, L., Johnson, J. J. Tags: Prevention Research Source Type: research

Abstract 2335: Thymoquinone induces the MUC4 mRNA-destabilizing activity of Tristetraprolin
In this study, we investigate that Tymoquinone (TQ) which is an active ingredient derived from the medicinal plant Nigella satia induces the TTP mRNA and protein expression in AGS and MDA-MB231. TQ treatment destabilized a luciferase mRNA containing cIAP2, VEGF and MUC4 ARE. Transfected cells were treated with various kinds of MAPK inhibitors, treatment with Sorafenib (RAF inhibitor) and U0126 (MEK-1/2) reduced the TTP induction activity of TQ in a dose-dependent manner. We confirmed that co-treatment with sorafenib/U0126 and TQ also reduced TTP expression. Following TQ downregulated the expression of MUC4 in previous stud...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Lee, H. H., Lee, S.-R., Leem, S.-H. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4110: Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis
Conclusions: Our study demonstrated that gartanin inhibited proliferation and induced apoptosis on prostate cancer cells in vitro. It achieves its anticancer effects partly through inhibiting AR and promoting ER stress. The ability of gartanin to inhibit prostate cancer cells suggests further research is needed to evaluate gartanin as a novel agent for the management of prostate cancer. Citation Format: Gongbo Li, Sakina Petiwala, Jeremy Johnson. Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis. [abstract]. In: Proceedings of the 105th Annua...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Li, G., Petiwala, S., Johnson, J. Tags: Prevention Research Source Type: research

Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression.
In conclusion, Rg3 effectively inhibited melanoma cell growth by downregulating FUT4 both in vitro and in vivo. Targeting FUT4/LeY mediated fucosylation by Rg3 inhibited the activation of EGFR/MAPK pathway and prevented melanoma growth. Results from this study suggest Rg3 is a potential novel therapy agent for melanoma treatment. PMID: 25672851 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - February 10, 2015 Category: Cancer & Oncology Authors: Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research

Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
Conclusions: Taken together, these results suggest that a NOX4-dependent pathway plays an important role in regulating the inhibitory effect of QYGS. Our findings provide new insights into the molecular mechanisms of QYYYG and their role in the treatment of hypertensive nephropathy.
Source: BMC Complementary and Alternative Medicine - March 25, 2015 Category: Complementary Medicine Authors: Kang DingYan WangWeimin JiangYu ZhangHongping YinZhuyuan Fang Source Type: research

Par‐4 dependent modulation of cellular β‐catenin by medicinal plant natural product derivative 3‐azido Withaferin A
This study, for the first time, reveals 3‐AWA treatment consistently sequestered nuclear β‐catenin and augmented its cytoplasmic pool as evidenced by reducing β‐catenin transcriptional activity in these cells. Moreover, 3‐AWA treatment triggered robust induction of pro‐apoptotic intracellular Par‐4, attenuated Akt activity and rescued Phospho‐GSK3β (by Akt) to promote β‐catenin destabilization. Further, our in vitro studies demonstrate that 3‐AWA treatment amplified E‐cadherin expression along with sharp downregulation of c‐Myc and cyclin D1 proteins. Strikingly, endogenous Par‐4 knock down by s...
Source: Molecular Carcinogenesis - May 12, 2015 Category: Molecular Biology Authors: Hina Amin, Debasis Nayak, Reyaz ur Rasool, Souneek Chakraborty, Anmol Kumar, Khalid Yousuf, Parduman Raj Sharma, Zabeer Ahmed, Neelam Sharma, Asmita Magotra, Debaraj Mukherjee, Lekha Dinesh Kumar, Anindya Goswami Tags: Research Article Source Type: research

Tanshinones suppress AURKA through up-regulation of miR-32 expression in non-small cell lung cancer.
Authors: Ma ZL, Zhang BJ, Wang DT, Li X, Wei JL, Zhao BT, Jin Y, Li YL, Jin YX Abstract Tanshinone is the liposoluble constituent of Salia miltiorrhiza, a root used in traditional herbal medicine which is known to possess certain health benefits. Although it is known that tanshinones, including tanshinone I (T1), tanshinone IIA (T2A), and cryptotanshinone (CT), can inhibit the growth of lung cancer cells in vitro, the mechanism under which they act is still unclear. AURKA, an oncogene, encodes a serine-threonine kinase which regulates mitotic processes in mammalian cells. Here, we reported that tanshinones mediate ...
Source: Oncotarget - June 5, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Ursolic acid protects hepatocytes against lipotoxicity through activating autophagy via an AMPK pathway
Publication date: August 2015 Source:Journal of Functional Foods, Volume 17 Author(s): Fanyu Meng , Hua Ning , Zongxiang Sun , Fangfang Huang , Yanchuan Li , Xia Chu , Huimin Lu , Changhao Sun , Songtao Li Ursolic acid is a naturally occurring pentacyclic triterpenoid in many plants, such as medicinal herbs and food, and was previously found to be an effective phytochemical that protected against high-fat diet-induced hepatic steatosis and liver injury. However, the molecular mechanisms are not fully determined. The present study examined the protective role of ursolic acid against saturated fatty acid-induced lipotoxici...
Source: Journal of Functional Foods - June 7, 2015 Category: Nutrition Source Type: research

Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
In conclusion, Rg3 induces tumor cell apoptosis correlated with its inhibitory effect on NF-κB signaling pathway-mediated FUT4 expression. Results suggest Rg3 might be a novel therapy agent for melanoma treatment. PMID: 26094873 [PubMed - as supplied by publisher]
Source: International Journal of Oncology - June 18, 2015 Category: Cancer & Oncology Authors: Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW Tags: Int J Oncol Source Type: research